02404oam 2200505 450 991078732980332120190911103513.00-429-07190-61-4665-7221-310.1201/b16259(OCoLC)868928102(MiFhGG)GVRL8QEG(EXLCZ)99267000000039435420130920h20142014 uy 0engurun|---uuuuatxtccrAnalysis of complex diseases a mathematical perspective /Guanyu WangBoca Raton :CRC Press, Taylor & Francis Group,[2014]�20141 online resource (xxi, 196 pages) illustrations (some color)Gale eBooksDescription based upon print version of record.1-4665-7223-X Includes bibliographical references.Food intake and energy metabolism -- Glucose homeostasis -- Optimal glucose homeostasis -- Bistability as a fundamental phenomenon -- Biomolecular network -- P13K-AKT-TOR pathway -- Diseases related to metabolism -- Mathematical modeling of the P13K-AKT-TOR Pathway -- Fundamental decomposition -- Normal phenotype -- Disease phenotypes -- Tao of diseases.A complex disease involves many etiological and risk factors operating at multiple levels-molecular, cellular, organismal, and environmental. The incidence of such diseases as cancer, obesity, and diabetes are increasing in occurrence, urging us to think fundamentally and use a broader perspective to identify their connection and revolutionize treatments. The understanding of biological data derived from studying diseases can be enhanced by theories and mathematical models, which clarify the big picture and help to reveal the overarching mechanisms that govern complex biological phenomena.<MetabolismDisordersSystems biologyBiological modelsGenetic disordersMetabolismDisorders.Systems biology.Biological models.Genetic disorders.616.3/9Wang Guanyu(Physicist),1584767MiFhGGMiFhGGBOOK9910787329803321Analysis of complex diseases3868735UNINA