00931cam0 22002773 450 SON000168920230112085549.0881322715920000720d2000 |||||ita|0103 baitaITAccordo normativo e autonomia negozialeAndrea OrestanoPadovaCEDAM2000X, 288 p.24 cmQuaderni Romani di diritto privato7001LAEC000154652001 *Quaderni Romani di diritto privato7Orestano, AndreaAF00004100070279387ITUNISOB20230112RICAUNISOBUNISOB340102826SON0001689M 102 Monografia moderna SBNM340002737SI102826acquistocarranoUNISOBUNISOB20110922112915.020110922112946.0carranoAccordo normativo e autonomia negoziale167125UNISOB05342nam 2200673 450 991078726560332120230120002054.00-12-802527-10-12-802215-9(CKB)3710000000307997(EBL)1882925(SSID)ssj0001548651(PQKBManifestationID)16153212(PQKBTitleCode)TC0001548651(PQKBWorkID)14802531(PQKB)10778049(MiAaPQ)EBC1882925(Au-PeEL)EBL1882925(CaPaEBR)ebr10996642(CaONFJC)MIL785267(OCoLC)898102459(EXLCZ)99371000000030799720150108h20142014 uy 0engur|n|---|||||txtccrEnzymesVolume thirty-sixNatural products and cancer signaling : isoprenoids, polyphenols and flavonoids /edited by S. Zahra Bathaie, Fuyuhiko Tamanoi ; contributors, Javad Alizadeh [and twenty-nine others]First edition.London, [England] :Academic Press,2014.©20141 online resource (279 p.)Enzymes ;Volume 36Description based upon print version of record.Includes bibliographical references at the end of each chapters and indexes.Front Cover; The Enzymes: Natural Products and Cancer Signaling: Isoprenoids, Polyphenols and Flavonoids; Copyright; Contents; Contributors; Preface; Chapter One: Introduction; References; Chapter Two: Perillyl Alcohol (Monoterpene Alcohol), Limonene; 1. Introduction; 2. Perillyl Alcohol; 2.1. Perillyl Alcohol Mechanism of Action in Cancer Therapy and Pharmacokinetics; 2.2. Perillyl Alcohol Biosafety and Adverse Effects in Clinical Application and Clinical Trials; 3. Limonene; 3.1. Limonene Pharmacokinetics; 3.2. Limonene Anticancer Activity and Clinical Trials3.3. Limonene Mechanisms of Action, Targets, and Clinical Applications3.4. Limonene Biosafety and Adverse Effects; 4. Concluding Remarks; Acknowledgment; References; Chapter Three: Ganoderic Acid and Lucidenic Acid (Triterpenoid); 1. Introduction; 2. Lucidenic Acids and Ganoderic Acids from Ganoderma Species; 2.1. The Sources of Lucidenic Acids and Ganoderic Acids; 2.2. The Biosynthesis of Ganoderic Acids; 2.3. Optimization of the Fermentation Process; 3. Biological Functions of Lucidenic Acids and Ganoderic Acids; 3.1. Cytotoxic and Apoptotic Effects; 3.2. Cell Cycle Arrest3.3. Anti-invasive Effect3.4. Autophagy; 3.5. Anti-inflammatory Effect; 3.6. Antiosteoclastogenesis; 3.7. Antiasthma; 3.8. Antihepatitis B Activity; 4. Pharmacokinetics of Ganoderic Acids; 5. Conclusion; References; Chapter Four: Anticancer Effect and Molecular Targets of Saffron Carotenoids; 1. Introduction; 2. Anticancer Effect of Saffron and Its Carotenoids; 3. Comparing the Efficacy of Crocetin, Crocin, and Other Components; 4. Liposome Formulation of Saffron Compounds; 5. Effect of Crocetin and Crocin on Macromolecule Synthesis and Structure5.1. Effect on DNA, RNA, and Protein Synthesis5.2. Protein Binding; 6. Effects on Cell Cycle, Apoptosis, and Signaling Pathways; 7. Role of Saffron Components on Chemoprevention; 8. Molecular Mechanisms Involved in the Protective Effect of Saffron Components against Various Damages in Different Tissues; 9. Antioxidant and Anti-inflammatory Effects of Saffron; 10. Safety; 11. Other Mechanisms; 12. Conclusions; References; Chapter Five: Zerumbone from Ginger (Monoterpenoid); 1. Introduction; 2. Characteristic Feature; 3. Target Pathways by Zerumbone; 3.1. Survival; 3.1.1. Caspase Family3.1.2. Bcl Family3.1.3. c-FLIP; 3.1.4. G2/M Cell Cycle; 3.2. Proliferation; 3.2.1. Cyclin B1/CDK1; 3.2.2. Tumor Necrosis Factor; 3.3. Invasion; 3.4. Angiogenesis; 4. Nuclear Factor-Kappa B; 5. Future Perspectives; References; Chapter Six: Research Progress on Natural Triterpenoid Saponins in the Chemoprevention and Chemotherapy of Cancer; 1. Introduction; 2. Triterpenoid Saponins in the Prevention and Therapy of Cancers; 3. Anticancer Properties and Molecular Mechanisms of Triterpenoid Saponins; 3.1. Inhibition of Proliferation; 3.2. Induction of Apoptosis and Autophagy; 3.2.1. Apoptosis3.2.2. AutophagyNatural compounds from a variety of natural resources including plants have emerged as important source of anticancer drug development. This special issue will highlight the significant advance in elucidating mechanisms of action of these natural compounds, focusing especially on isoprenoids and polyphenols/flavonoids. <br><br> Key features: * Contributions from leading authorities * Informs and updates on all the latest developments in the fieldEnzymes ;Volume 36.CancerAlternative treatmentCancerTreatmentCancerAlternative treatment.CancerTreatment.616.994061Bathaie S. ZahraTamanoi FuyuhikoAlizadeh JavadMiAaPQMiAaPQMiAaPQBOOK9910787265603321Enzymes367093UNINA