03172nam 2200589Ia 450 991078635520332120230919234413.01-84755-770-8(CKB)2670000000276250(EBL)1185544(SSID)ssj0000755768(PQKBManifestationID)11440209(PQKBTitleCode)TC0000755768(PQKBWorkID)10732643(PQKB)11735080(MiAaPQ)EBC1185544(Au-PeEL)EBL1185544(CaPaEBR)ebr10618749(CaONFJC)MIL871916(OCoLC)232639136(PPN)19846777X(EXLCZ)99267000000027625020080204h20072007 uy 0engur|n|---|||||txtrdacontentcrdamediacrrdacarrierFreeze-drying of pharmaceuticals and biopharmaceuticals [principles and practice] /Felix Franks ; in association with Tony AuffretCambridge :RSC Publishing,2007.©20071 online resource (xii, 206 pages) illustrationsDescription based upon print version of record.0-85404-151-6 Includes bibliographical references (p. 190-200) and index.Freeze-drying, in the past popular in the food industry, has more recently been adopted by the pharmaceutical industry as a standard method for the production of stable solid preparations. Freeze-drying of Pharmaceuticals and Biopharmaceuticals is the first book to specifically describe this process, as related to the pharmaceutical industry. The emphasis of this book is on the properties of the materials processed, how effective formulations are arrived at, and how they are stored and marketed. Beginning with a historical overview of the process, Freeze-drying of Pharmaceuticals and Biopharmaceuticals briefly describes the processes and equipment involved, including: the physics, chemistry and biochemistry associated with freezing, aspects of formulation development, primary and secondary drying; the economics and engineering of scaling up; and, most importantly, attributes of the dried product. It also discusses in detail the science behind freeze-drying, such as the properties of crystalline and amorphous solids. The book concludes with selected case studies and discusses the future of freeze-drying, advances in alternative drying methods, and concludes with an extensive bibliography. This book, written by a leading expert in the field, is aimed primarily at product and process developers in the biopharmaceutical industry and academia.Frozen drugsFreeze-dryingBiopharmaceuticsFrozen drugs.Freeze-drying.Biopharmaceutics.615.18Franks Felix18323Auffret Tony1570002MiAaPQMiAaPQMiAaPQBOOK9910786355203321Freeze-drying of pharmaceuticals and biopharmaceuticals3843348UNINA