05492 am 2200781 n 450 99104180497033212020021184-9096-261-8(CKB)4100000010268610(FrMaCLE)OB-cvz-9296(oapen)https://directory.doabooks.org/handle/20.500.12854/57000(PPN)243134363(EXLCZ)99410000001026861020200217j|||||||| ||| 0freuu||||||m||||txtrdacontentcrdamediacrrdacarrierPrivauté, gouvernement et souveraineté Castille, xiiie-xive siècle /François ForondaMadrid Casa de Velázquez20201 online resource (294 p.) Long before the favourites of early modern times, the kings of medieval Europe relied on similar figures in their entourage. Those early experiences of proximity were not as thorough everywhere. Castile, where it was especially long-lasting, is a particularly favourable ground to investigate the identity of the medieval privanza and its historical meaning. The privanza is a choice, that of friendship against kinship. This choice was made on ideological grounds from the middle of the 13th century, and then became a strategy at the beginning of the 14th century: against his parents and barons, who wanted to exert a hold on his royalty, the king launched his creatures, the privados, to emancipate himself from them. While they worked towards an expulsion, they also organized an alternative and broader form of participation in the king's government, of his own person and his kingdom. Thus, the privanza reveals how the royal company was affected by a societal overthrow from the 13th century onwards. The multiple experimentations of privanza in the fourteenth century founded a political regime marked by the distinction between government and sovereignty. This essay takes a fresh look at this founding moment in the medieval experiment of state power.--Publisher's website.84-9096-260-X Avant le temps des ministres-favoris de l’époque baroque, les rois de l’Europe médiévale ont compté dans leur proximité sur l’assistance de personnages souvent vus comme leur préfiguration. Cette expérience de la privauté n’est cependant pas partout de même intensité. Ainsi, la Castille de la fin du Moyen Âge se distingue-t-elle par une continuité d’expérience. Ce terrain s’avère donc particulièrement propice pour interroger l’identité de la privauté médiévale, son sens historique. La privauté (privanza) est un choix, celui de l’amitié contre la parenté. Réalisé sur le terrain idéologique à partir du milieu du xiiie siècle, ce choix se fait stratégique au début du xive siècle : contre ses parents et ses barons, qui entendent exercer une emprise sur sa royauté, le roi lance ses créatures, les privados, pour s’en libérer. Si ceux-ci oeuvrent donc à une expulsion, ils organisent dans le même temps une participation alternative et plus large au gouvernement du roi, celui de sa personne et de son royaume. La privauté fait ainsi sentir quel dépassement sociétal affecte la compagnie royale à partir du xiiie siècle. Et la répétition des expériences de privauté au xive siècle fonde un régime politique, marqué par la distinction entre gouvernement et souveraineté. Cet essai envisage à nouveaux frais ce moment fondateur de l’expérience médiévale du pouvoir d’État. Este libro ofrece un análisis renovado de la privanza en Castilla en los siglos xiii y xiv con el fin de aclarar el carácter propiamente medieval de la cercanía regia. Si esta relación estructurada por lazos personales produce, paradójicamente, la autonomía del gobierno, es porque supone una elección rupturista que participa de la «desparentalización» de lo social en la Edad Media: la de la amistad frente al parentesco. Long before the favourites of early modern times, the kings of medieval Europe relied on similar figures in their entourage. Those early experiences of proximity were not as thorough everywhere.…HistoryMedieval & Renaissance StudiesCastilleMoyen Âgeamitié gouvernementaleprivautérégime politiquesouverainetéprivadoamistad gubernamentalCastillaEdad Mediaprivanzarégimen políticosoberaníaprivanzaamistad gubernamentalsoberaníarégimen políticoEdad MediaCastillaprivadoHistoryMedieval & Renaissance StudiesCastilleMoyen Âgeamitié gouvernementaleprivautérégime politiquesouverainetéprivadoamistad gubernamentalCastillaEdad Mediaprivanzarégimen políticosoberaníaForonda François984516FR-FrMaCLEBOOK9910418049703321Privauté, gouvernement et souveraineté2249459UNINA05446nam 2200673Ia 450 991078465840332120230120004641.01-281-03721-497866110372150-08-054594-7(CKB)1000000000364013(EBL)299465(OCoLC)271426948(SSID)ssj0000112063(PQKBManifestationID)11142568(PQKBTitleCode)TC0000112063(PQKBWorkID)10085632(PQKB)10833929(MiAaPQ)EBC299465(Au-PeEL)EBL299465(CaPaEBR)ebr10186834(CaONFJC)MIL103721(EXLCZ)99100000000036401320070202d2007 uy 0engur|n|---|||||txtccrThe biology of human longevity[electronic resource] inflammation, nutrition, and aging in the evolution of lifespans /Caleb E. FinchAmsterdam ;Boston Academic Pressc20071 online resource (640 p.)Description based upon print version of record.0-12-373657-9 Includes bibliographical references(p. 417-599) and indexes.Front Cover; The Biology of Human Longevity; Copyright Page; Contents; Preface; Acknowledgments; Chapter 1: Inflammation and Oxidation in Aging and Chronic Diseases; Part I; 1.1. Overview; 1.2. Experimental Models for Aging; 1.2.1. Mortality Rate Accelerations; 1.2.2. Mammals; 1.2.3. Cultured Cell Models and Replicative Senescence; 1.2.4. Invertebrate Models; 1.2.5. Yeast; 1.2.6. The Biochemistry of Aging; 1.2.7. Biomarkers of Aging and Mortality Risk Markers; 1.2.8. Evolutionary Theories of Aging; 1.3. Outline of Inflammation; 1.3.1. Innate Defense Mechanisms1.3.2. Genetic Variations of Inflammatory Responses1.3.3. Inflammation and Energy; 1.3.4. Amyloids and Inflammation; 1.4. Bystander Damage and Dependent Variables in Senescence; 1.4.1. Free Radical Bystander Damage (Type 1); 1.4.2. Glyco-oxidation (Type 2); 1.4.3. Chronic Proliferation (Type 3); 1.4.4. Mechanical Bystander Effects (Type 4); Part II; 1.5. Arterial Aging and Atherosclerosis; 1.5.1. Overview and Ontogeny; 1.5.2. Hazards of Hypertension; 1.5.3. Mechanisms; 1.5.3.1. Inflammation; 1.5.3.2. Hemodynamics; 1.5.3.3. Aging; 1.5.3.4. Endothelial Progenitor Cells1.5.4. Blood Risk Factors for Vascular Disease and Overlap with Acute Phase Responses1.6. Alzheimer Disease and Vascular-related Dementias; 1.6.1. Neuropathology of Alzheimer Disease; 1.6.2. Inflammation in Alzheimer Disease; 1.6.3. Prodromal Stages of Alzheimer Disease; 1.6.4. Overlap of Alzheimer and Cerebrovascular Changes; 1.6.5. Insulin and IGF-1 in Vascular Disease and Alzheimer Disease; 1.6.6. Blood Inflammatory Proteins: Markers for Disease or Aging, or Both?; 1.7. Inflammation in Obesity; 1.8. Processes of Normal Aging in the Absence of Specific Diseases; 1.8.1. Brain1.8.2. Generalized Inflammatory Changes in Normal Tissue Aging1.9. Summary; Chapter 2 :Infections, Inflammogens, and Drugs; 2.1. Introduction; 2.2. Vascular Disease; 2.2.1. Historical Associations of Infections and Vascular Mortality; 2.2.2. Modern Serologic Associations; 2.3. Infections from the Central Tube: Metchnikoff Revisited; 2.3.1. Humans: Leakage from Periodontal Disease and Possibly the Lower Intestine; 2.3.2. Worms and Flies as Models for Human Intestinal Microbial Intrusion; 2.4. Aerosols and Dietary Inflammogens; 2.4.1. Aerosols; 2.4.2. Food2.5. Infections, Inflammation, and Life Span2.5.1. Historical Human Populations; 2.5.2. Longer Rodent Life Spans with Improved Husbandry; 2.6. Are Infections a Cause of Obesity?; 2.7. Inflammation, Dementia, and Cognitive Decline; 2.7.1. Alzheimer Disease; 2.7.2. HIV, Dementia, and Amyloid; 2.7.3. Peripheral Amyloids; 2.7.4. Inflammation and Cognitive Decline During 'Usual' Aging; 2.8. Immunosenescence and Stem Cells; 2.8.1. Immunosenescence and Cumulative Exposure; 2.8.2. Immunosenescence and Telomere Loss; 2.8.3. Inflammation and Stem Cells; 2.9. Cancer, Infection, and Inflammation2.9.1. Helicobacter Pylori and Hepatitis B VirusWritten by Caleb Finch, one of the leading scientists of our time, The Biology of Human Longevity - Inflammation, Nutrition, and Aging in the Evolution of Lifespans synthesizes several decades of top research on the topic of human aging and longevity particularly on the recent theories of inflammation and its effects on human health. The book expands a number of existing major theories, including the Barker theory of fetal origins of adult disease to consider the role of inflammation and Harmon's free radical theory of aging to include inflammatory damage. Future increases in lifespan aLongevityPhysiological aspectsAgingPhysiological aspectsInflammationNutritionLongevityPhysiological aspects.AgingPhysiological aspects.Inflammation.Nutrition.612.6/8Finch Caleb Ellicott1497188MiAaPQMiAaPQMiAaPQBOOK9910784658403321The biology of human longevity3722238UNINA