03160nam 22006134a 450 991078454280332120200520144314.01-281-03696-X97866110369660-08-054609-9(CKB)1000000000364644(EBL)299440(OCoLC)476077150(SSID)ssj0000157500(PQKBManifestationID)11148848(PQKBTitleCode)TC0000157500(PQKBWorkID)10139645(PQKB)10045252(MiAaPQ)EBC299440(Au-PeEL)EBL299440(CaPaEBR)ebr10186727(CaONFJC)MIL103696(PPN)182565467(EXLCZ)99100000000036464420070125d2007 uy 0engur|n|---|||||txtccrFoundations of comparative genomics[electronic resource] /Arcady R. MushegianAmsterdam ;Boston Academic Pressc20071 online resource (276 p.)Description based upon print version of record.0-12-088794-0 Includes bibliographical references (p. 238-257) and index.The beginning of computational genomics -- Finding sequence similarities -- Homology: can we get it right? -- Getting ready for the era of comparative genomics: the importance of viruses -- The first fact of comparative genomics: protein sequences are remarkably resilient in evolution -- The second fact of comparative genomics: functional convergence at the molecular level -- Prediction of function and reconstruction of metabolism from genomic data: homology-based approaches -- Prediction of function and reconstruction of metabolism: post-homology approaches -- Structural genomics: what does it tell us about life? -- How many protein families are there? -- Phylogenetic inference and the era of complete genomes -- Two stories about evolution -- Minimal and ancestral genomes -- Comparative genomics and systems biology.This book provides an overview of computational analysis of genes and genomes, and of some most notable findings that come out of this work. Foundations of Comparative Genomics presents a historical perspective, beginning with early analysis of individual gene sequences, to present day comparison of gene repertoires encoded by completely sequenced genomes. The author discusses the underlying scientific principles of comparative genomics, argues that completion of many genome sequences started a new era in biology, and provides a personal view on several state-of-the-art issues, such as GenomicsGene mappingPhysiology, ComparativeGenomics.Gene mapping.Physiology, Comparative.572.8/6 22572.86Mushegian Arcady R1528715MiAaPQMiAaPQMiAaPQBOOK9910784542803321Foundations of comparative genomics3772548UNINA