03082nam 2200613Ia 450 991078391350332120230617040745.01-281-89708-69786611897086981-270-136-2(CKB)1000000000334358(EBL)296094(OCoLC)476063316(SSID)ssj0000127561(PQKBManifestationID)11141478(PQKBTitleCode)TC0000127561(PQKBWorkID)10054415(PQKB)11680412(MiAaPQ)EBC296094(WSP)00000752 (Au-PeEL)EBL296094(CaPaEBR)ebr10173947(CaONFJC)MIL189708(OCoLC)228170004(EXLCZ)99100000000033435820040903d2005 uy 0engur|n|---|||||txtccrComputational biology of cancer[electronic resource] lecture notes and mathematical modeling /Dominik Wodarz and Natalia KomarovaHackensack, NJ World Scientific20051 online resource (266 p.)Description based upon print version of record.981-256-027-0 Includes bibliographical references and index.Preface; Contents; Chapter 1 Cancer and somatic evolution; Chapter 2 Mathematical modeling of tumorigenesis; Chapter 3 Cancer initiation: one-hit and two-hit stochastic models; Chapter 4 Microsatellite and chromosomal instability in sporadic and familial cancers; Chapter 5 Cellular origins of cancer; Chapter 6 Costs and benefits of chromosomal instability; Chapter 7 DNA damage and genetic instability; Chapter 8 Tissue aging and the development of cancer; Chapter 9 Basic models of tumor inhibition and promotion; Chapter 10 Mechanisms of tumor neovascularizationChapter 11 Cancer and immune responsesChapter 12 Therapeutic approaches: viruses as anti-tumor weapons; Appendix A Exact formula for total probability of double mutations; Bibliography; IndexThe book shows how mathematical and computational models can be used to study cancer biology. It introduces the concept of mathematical modeling and then applies it to a variety of topics in cancer biology. These include aspects of cancer initiation and progression, such as the somatic evolution of cells, genetic instability, and angiogenesis. The book also discusses the use of mathematical models for the analysis of therapeutic approaches such as chemotherapy, immunotherapy, and the use of oncolytic viruses.CancerMathematical modelsCancerResearchCancerMathematical models.CancerResearch.616.99/4/00724Wodarz Dominik721741Komarova Natalia L721742MiAaPQMiAaPQMiAaPQBOOK9910783913503321Computational biology of cancer3738908UNINA