03388nam 2200433z- 450 991034674190332120231214132939.0(CKB)4920000000094295(oapen)https://directory.doabooks.org/handle/20.500.12854/57915(EXLCZ)99492000000009429520202102d2018 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierRedox and Metabolic Circuits in CancerFrontiers Media SA20181 electronic resource (183 p.)Frontiers Research Topics2-88945-635-8 Living cells require a constant supply of energy for the orchestration of a variety of biological processes in fluctuating environmental conditions. In heterotrophic organisms, energy mainly derives from the oxidation of carbohydrates and lipids, whose chemical bonds breakdown allows electrons to generate ATP and to provide reducing equivalents needed to restore the antioxidant systems and prevent from damage induced by reactive oxygen and nitric oxide (NO)-derived species (ROS and RNS). Studies of the last two decades have highlighted that cancer cells reprogram the metabolic circuitries in order to sustain their high growth rate, invade other tissues, and escape death. Therefore, this broad metabolic reorganization is mandatory for neoplastic growth, allowing the generation of adequate amounts of ATP and metabolites, as well as the optimization of redox homeostasis in the changeable environmental conditions of the tumor mass. Among these, ROS, as well as NO and RNS, which are produced at high extent in the tumor microenvironment or intracellularly, have been demonstrated acting as positive modulators of cell growth and frequently associated with malignant phenotype. Metabolic changes are also emerging as primary drivers of neoplastic onset and growth, and alterations of mitochondrial metabolism and homeostasis are emerging as pivotal in driving tumorigenesis. Targeting the metabolic rewiring, as well as affecting the balance between production and scavenging of ROS and NO-derived species, which underpin cancer growth, opens the possibility of finding selective and effective anti-neoplastic approaches, and new compounds affecting metabolic and/or redox adaptation of cancer cells are emerging as promising chemotherapeutic tools. In this Research Topic we have elaborated on all these aspects and provided our contribution to this increasingly growing field of research with new results, opinions and general overviews about the extraordinary plasticity of cancer cells to change metabolism and redox homeostasis in order to overcome the adverse conditions and sustain their “individualistic” behavior under a teleonomic viewpoint.hypoxiaMitochondriaBioenergeticsCancer MetabolismROSS-nitrosylationAutophagyredoxWarburg effectSalvatore Rizzaauth1320441Giuseppe FilomeniauthAndrea RasolaauthDanyelle M. TownsendauthBOOK9910346741903321Redox and Metabolic Circuits in Cancer3034312UNINA03371oam 2200769I 450 991078363820332120230421043237.00-7546-1947-81-134-71179-41-134-71180-80-203-15848-21-280-33488-60-203-00539-210.4324/9780203005392(CKB)1000000000247614(EBL)165188(OCoLC)56994029(SSID)ssj0000070877(PQKBManifestationID)11109762(PQKBTitleCode)TC0000070877(PQKBWorkID)10070030(PQKB)11765538(MiAaPQ)EBC165188(Au-PeEL)EBL165188(CaPaEBR)ebr10056097(CaONFJC)MIL33488(OCoLC)48138503(EXLCZ)99100000000024761420180331d1998 uy 0engur|n|---|||||txtccrAfrican identities race, nation, and culture in ethnography, pan-Africanism, and black literatures /Kadiatu KannehLondon ;New York :Routledge,1998.1 online resource (217 p.)Description based upon print version of record.0-415-16445-1 0-415-16444-3 Includes bibliographical references (p.193-199) and index.Book Cover; Title; Contents; Introduction; Acknowledgements; The meaning of Africa: texts and histories; 'Coming home': Pan-Africanisms and national identities; Remembered landscapes: African-American appropriations of Africa; Crossing borders: race, sexuality and the body; Afterword; Bibliography; IndexThis fascinating and well researched study explores the meaning generated by `Africa' and `Blackness' throughout the century. Using literary texts, autobiography, ethnography, and historical documents, African Identities discusses how ideas of Africa as an origin, as a cultural whole, or as a complicated political problematic, emerge as signifiers for analysis of modernity, nationhood and racial difference. Kanneh provides detailed readings of a range of literary texts, including novels by: * Toni Morrison * Alice Walker * Gloria Naylor * Ngugi Wa Thiong'oBlack peopleRace identityAfrican AmericansRace identityBlack people in literatureWomen, Black, in literatureEnglish fiction19th centuryHistory and criticismEnglish fiction20th centuryHistory and criticismEnglish fictionBlack authorsHistory and criticismAfrica, Sub-SaharanIn literatureBlack peopleRace identity.African AmericansRace identity.Black people in literature.Women, Black, in literature.English fictionHistory and criticism.English fictionHistory and criticism.English fictionBlack authorsHistory and criticism.305.896Kanneh Kadiatu1966,1489866MiAaPQMiAaPQMiAaPQBOOK9910783638203321African identities3710750UNINA