02779nam 2200589Ia 450 991078348420332120230617034153.01-281-86650-497866118665011-86094-544-9(CKB)1000000000032775(EBL)224807(OCoLC)57748880(SSID)ssj0000251020(PQKBManifestationID)11219665(PQKBTitleCode)TC0000251020(PQKBWorkID)10245163(PQKB)10105718(MiAaPQ)EBC224807(WSP)0000P321(Au-PeEL)EBL224807(CaPaEBR)ebr10082180(EXLCZ)99100000000003277520040609d2004 uy 0engurcnu---unuuutxtccrStatistical aspects of the design and analysis of clinical trials[electronic resource] /Brian S. Everitt, Andrew PicklesRev. ed.London Imperial College Press ;River Edge, NJ Distributed by World Scientific Pub. Co.20041 online resource (338 p.)Description based upon print version of record.1-86094-441-8 Includes bibliographical references (p. 303-319) and index.An introduction to clinical trials -- Treatment allocation, the size of trials and reporting results -- Monitoring trial progress: outcome measures, compliance, dropouts and interim analyses -- Basic analyses of clinical trials, the generalized linear model and the economic evaluation of trials -- Simple approaches to the analysis of longitudinal data from clinical trials -- Multivariate normal regression models for longitudinal data from clinical trials -- Models for non-normal longitudinal data from clinical trials -- Survival analysis -- Bayesian methods longitudinal data -- Meta-analysis.Fully updated, this revised edition describes the statistical aspects of both the design and analysis of trials, with particular emphasis on the more recent methods of analysis.About 8000 clinical trials are undertaken annually in all areas of medicine, from the treatment of acne to the prevention of cancer.Clinical trialsStatistical methodsClinical medicineResearchClinical trialsStatistical methods.Clinical medicineResearch.615.10727Everitt Brian56108Pickles Andrew1565761MiAaPQMiAaPQMiAaPQBOOK9910783484203321Statistical aspects of the design and analysis of clinical trials3835711UNINA