02496nam 22005534a 450 991078305150332120230207223407.01-61091-092-31-4175-4387-6(CKB)1000000000004741(EBL)3317351(OCoLC)923186742(SSID)ssj0000193632(PQKBManifestationID)11216135(PQKBTitleCode)TC0000193632(PQKBWorkID)10226586(PQKB)11458160(MiAaPQ)EBC3317351(Au-PeEL)EBL3317351(CaPaEBR)ebr10064701(EXLCZ)99100000000000474120030724d2003 uy 0engur|n|---|||||txtccrLiving with the Genie[electronic resource] essays on technology and the quest for human mastery /edited by Alan Lightman, Daniel Sarewitz, Christina DesserWashington Island Pressc20031 online resource (358 p.)Description based upon print version of record.1-55963-419-7 About Island Press; Title Page; Copyright Page; Contents; Introduction; Ch 1: Literary Devices; Ch 2: The Origin od the Genie; Ch 3: Promise and Peril; Ch 4: Small Is Powerful; Ch 5: Your Breath Is Your Worst Enemy; Ch 6: Changing Conceptions; Ch 7: Technology and Death; Ch 8: Confined to Your Legs; Ch 9: Progress and Violence; Ch 10: Science and Happiness; Ch 11: What Kinds of Science Should Be Done?; Ch 12: The Humpty Dumpty Problem; Ch 13: Who Owns Your Dinner?; Ch 14: Blowback in Genetic Engineering; Ch 15: Only Connect; Ch 16: The World is Too Much With Me; Acknowledgments; NotesChapter 2 & 3Chapter 4; Chapter 5; Chapter 6; Chapter 7; Chapter 8; Chapter 9; Chapter 10; Chapter 11; Chapter 13; Chapter 14; Chapter 15; About the Authors; Index; IslandPress Board of Directors 2003TechnologySocial aspectsTechnological innovationsSocial aspectsTechnologySocial aspects.Technological innovationsSocial aspects.303.48/3Lightman Alan P.1948-40367Sarewitz Daniel R1536527Desser Christina1548305MiAaPQMiAaPQMiAaPQBOOK9910783051503321Living with the Genie3805238UNINA05236nam 2200661Ia 450 991096339230332120251116181411.01-61942-455-X(CKB)2550000001040563(EBL)3017654(SSID)ssj0000826844(PQKBManifestationID)12407503(PQKBTitleCode)TC0000826844(PQKBWorkID)10809291(PQKB)11123435(MiAaPQ)EBC3017654(Au-PeEL)EBL3017654(CaPaEBR)ebr10654625(OCoLC)923652879(BIP)38864351(BIP)34337361(EXLCZ)99255000000104056320110329d2012 uy 0engur|n|---|||||txtccrDNA replication and mutation /Raymond P. Leitner, editor1st ed.Hauppauge, NY Nova Science20121 online resource (204 p.)DNA and RNADescription based upon print version of record.1-61324-490-8 Includes bibliographical references (p. 158-177) and index.""DNA REPLICATIONAND MUTATION""; ""DNA AND RNA: PROPERTIESAND MODIFICATIONS, FUNCTIONSAND INTERACTIONS, RECOMBINATIONAND APPLICATIONS""; ""Library of Congress Cataloging-in-Publication Data""; ""Contents""; ""Preface""; ""Connections between BLMand the Fanconi AnemiaPathway in the Repair ofReplication Fork Damage""; ""Abstract""; ""RecQ DNA Helicases""; ""BLM and Regulationof Homologous Replication""; ""Connections between FANCM of the FanconiAnemia Pathway and BLM""; ""Connections between FANCJ of the FAPathway and BLM""""The Structure-Specific EndonucleaseSLX4-SLX1 and Its Relationshipto BLM and the FA Pathway""""Conclusion""; ""Acknowledgments""; ""References""; ""Mutagenic Potentialof Methacrylates Usedin Restorative Dentistry""; ""Abstract""; ""Introduction""; ""Materials and Methods""; ""Chemicals""; ""Cells""; ""Cell Treatment""; ""Cell Viability""; ""Plasmid Relaxation Assay""; ""Comet Assay""; ""Oxidative Damage to DNA""; ""DNA Double-Strand Breaks Assays""; ""Apoptosis""; ""Cell Cycle""; ""Data Analysis""; ""Results""; ""Cell Viability""; ""DNA Damage In Vitro""""DNA Damage in Human Gingival Fibroblasts""""DNA Double-Strand Breaks""; ""DNA Repair""; ""Oxidative Modifications to the DNA Bases""; ""Apoptosis""; ""Cell Cycle""; ""Discussion""; ""Acknowledgments""; ""Conflict of Interest Statement""; ""References""; ""DNA Mutation of theProgranulin (GRN) Gene inFamilial Frontotemporal LobarDegeneration (FTLD): A Studyof the Pathology of Nine Cases""; ""Abstract""; ""Introduction""; ""Heterogeneity of FTLD-TDP""; ""DNA Mutations""; ""Objectives""; ""Materials and Methods""; ""Cases""; ""Histological Methods""; ""Morphometric Measurements""""Measurement of Density of Inclusions""""Spatial Patterns of the Inclusions""; ""Laminar Distribution""; ""Density of TDP-43Immunoreactive Inclusions""; ""Spatial Patterns of TDP-43Immunoreactive Inclusions""; ""Laminar Distribution of TDP-43Immunoreactive Inclusions""; ""Conclusion""; ""Acknowledgments""; ""References""; ""Effect of a Specific MammalianDNA Polymerase α-Inhibitor,Dehydroaltenusin, on DNAReplication in Cultured Cells""; ""Abstract""; ""Abbreviations""; ""1. Introduction""; ""2. Production and Isolationof Dehydroaltenusin""""3. Effect of Dehydroaltenusin on Polsand other DNA Metabolic Enzymes""""4. Mode of Pol α Inhibitionby Dehydroaltenusin""; ""5. Effect of Dehydroaltenusinon Human Cancer Cell Growth""; ""6. Inhibitory Properties of ehydroaltenusinon Human Cancer Cell Growth""; ""7. Effect of Dehydroaltenusin on DNAReplication in NIH3T3 Cells""; ""8. Discussion""; ""Conclusion""; ""Acknowledgments""; ""References""; ""Gel-Based Methods Using DNABindingZinc(II) Complexesfor the Detectionof DNA Mutations""; ""Abstract""; ""Introduction""; ""Zinc(II)�Cyclen""""Zinc(II)�Cyclen PolyacrylamideGel Electrophoresis""In this book, the authors present current research in the study of DNA replication and mutation, including connections between BLM and the Fanconi anemia pathway in the repair of replication fork damage; the mutagenic potential of methacrylates used in restorative dentistry; DNA mutation of the progranulin gene in familial frontotemporal lobar degeneration; effect of DNA polymerase a-inhibitor dehydroaltenusin on DNA replication in cultured cells; gel-based methods of DNA-binding zinc II complexes in the detection of DNA mutations and DNA mutations and genetic coding.DNA and RNA : Properties and Modifications, Functions and Interactions, Recombination and ApplicationsDNA replicationDNASynthesisDNA replication.DNASynthesis.572.8/645572.8/645Leitner Raymond P1868804MiAaPQMiAaPQMiAaPQBOOK9910963392303321DNA replication and mutation4476833UNINA