04427nam 2200661Ia 450 991078288080332120230721005018.00-19-756250-70-19-988665-21-281-99848-697866119984860-19-804351-1(CKB)1000000000718579(EBL)416008(OCoLC)476246440(SSID)ssj0000262394(PQKBManifestationID)11220992(PQKBTitleCode)TC0000262394(PQKBWorkID)10269465(PQKB)11351084(MiAaPQ)EBC416008(StDuBDS)EDZ0002341663(Au-PeEL)EBL416008(CaPaEBR)ebr10288354(CaONFJC)MIL199848(EXLCZ)99100000000071857920080909d2009 uy 0engur|n|---|||||txtccrTriumph of the heart[electronic resource] the story of statins /Jie Jack LiNew York Oxford University Press20091 online resource (220 p.)Oxford scholarship onlinePreviously issued in print: 2009.0-19-532357-2 Includes bibliographical references (p. 175-188) and index.Foreword; Contents; 1 Cholesterol; The Janus-Faced Molecule; One of the 10 Greatest Discoveries in Medicine; The Good, the Bad, and the Ugly; Hitler's Gift; The Framingham Heart Study; The Receptor; 2 Genesis of Statins; Early Cholesterol Drugs; Nicotinic acid; Resins; Fibrates; I Refuse to Sign Th is Report!; Birth of Statins; Endo's discovery of the first statin; The fate of mevastatin; Endo's fate; How do statins work?; 3 Merck's Triumph; Merck; Humble beginnings; George W. Merck; Penicillin; Cortisone; Streptomycin; Glorious history; Mevacor and Zocor; The poor Greek immigrant kidPreludeDiscovery; Halt!; Triumph; The Company, the Drugs, and the Inventors Today; 4 Discovery of Lipitor; Splendid History; Parke, Davis & Company; Dilantin; Chloromycetin; The pill; Lopid; Roger S. Newton; Bruce D. Roth; The Discovery of Lipitor; Shoulders of giants; The first success . . . and disappointment; The second refrain; CI-971; CI-981; 5 Development of Lipitor; Checkered Life; Chiral or Not, You Have to Make It First; Clinical Trials-Divine Providence?; Canter and the FDA; What's in a Name?; A Marketing Partner; 6 To Market, to Market; Pfizer Inc.The small drug firm in Brooklyn made bigPenicillin; Drugs of its own; Windfall: The Era of Blockbusters; Viagra; Zoloft; Diflucan; Zithromax; Norvasc; The Merger; PROVE-IT; The Patent Litigation; 7 Baycol, Crestor, and Cholesterol Drugs beyond Statins; The Story of Baycol; Crestor; Cholesterol Drugs beyond Statins; Zetia and Vytorin; Torcetrapib, a bitter disappointment; ApoA-1 Milano and Newton; 8 Reflections; Triumph of the Heart; Statins set a high standard in efficacy; Statins set a high standard in safety; Statins set a high standard in financial benefitsThe Drug Industry and the Blockbuster ModelAppendix: Drug Names; Notes and References; Index; A; B; C; D; E; F; G; H; I; J; K; L; M; N; O; P; Q; R; S; T; U; V; W; X; Y; ZOver 25 million people in the U.S. alone have benefited from statins (such drugs as Lipitor, Zocor, Crestor, Pravachol) in preventing stroke, heart attack, and other forms of coronary heart disease. But how did these remarkable, life-saving drugs come into being? In Triumph of the Heart, Dr. Jie Jack Li, a medicinal chemist and expert on drug discovery, tells the fascinating story of statins. Drawn from interviews with many scientists involved in the discovery and development of these drugs, the book illuminates the human side of science by revealing the role played by persistence, luck, and sudden insight that characterise major discoveries.Oxford scholarship online.Statins (Cardiovascular agents)HistoryAnticholesteremic agentsStatins (Cardiovascular agents)History.Anticholesteremic agents.615/.718Li Jie Jack440094MiAaPQMiAaPQMiAaPQBOOK9910782880803321Triumph of the heart3867842UNINA