05158nam 2200661Ia 450 991078211690332120230617040912.01-281-93570-09786611935702981-279-529-4(CKB)1000000000537838(EBL)1679330(OCoLC)879023478(SSID)ssj0000113723(PQKBManifestationID)11140588(PQKBTitleCode)TC0000113723(PQKBWorkID)10100352(PQKB)11258515(MiAaPQ)EBC1679330(WSP)00005233(Au-PeEL)EBL1679330(CaPaEBR)ebr10255790(CaONFJC)MIL193570(EXLCZ)99100000000053783820040427d2003 uy 0engur|n|---|||||txtccrBone morphogenetic protein and collagen[electronic resource] an advances in tissue banking specialist publication /editor, Glyn O. PhillipsRiver Edge, NJ World Scientificc20031 online resource (169 p.)Series in allografts in bone healing ;v. 2"An Advances in tissue banking specialist publication."981-238-318-2 Includes bibliographical references.CONTENTS ; Introduction to the Series ; Preface ; List of Contributors ; Chapter 1 From Bone Allografts to Synthetic Bone Grafts: Bone Morphogenetic Proteins and Osteoinduction ; 1. Introduction ; 2. Bone Morphogenesis is a Cascade3. Purification Cloning and Expression of Recombinant BMPs 4. BMPs and Chondrogenesis and Cartilage Maintenance ; 5. BMPs: Pleiotropy and Thresholds ; 6. BMP Receptors and Smads ; 7. BMPs: Clinical Applications ; 8. Acknowledgements ; 9. ReferencesChapter 2 The Osteoinductive Properties of Demineralised Bone Matrix Grafts 1. Introduction ; 2. Factors Affecting the Osteoinductivity of DBM Grafts ; 3. Cellular Effects of DBM Grafts ; 4. The BMPs ; 5. DBM Grafts in Clinical Use ; 6. Assays For DBM Activity ; 7. ReferencesChapter 3 Processing Factors Contributing To Production Of Maximally Osteoinductive Demineralised Ground Bone For Use In Orthopaedic Or Periodontal Applications 1. Introduction ; 2. Cleaning of Bone ; 3. Demineralization of Bone ; 4. Determination of Osteoinductive Potential of Bone5. Summary and Conclusions 6. References ; Chapter 4 Clinical Effectiveness of Demineralised Bone Matrix Assayed in Human Cell Culture ; 1. Introduction ; 2. Material and Methods ; 3. Results ; 4. Discussion ; 5. Acknowledgement ; 6. ReferencesChapter 5 The Influence of Sterilisation on the Osteoinductive Properties of Bone in Rat Bone Marrow Cell CultureWhat are bone morphogenetic proteins (BMPs) and how can they be used in orthopaedic practice? Ever since Urist proposed in 1976 that protein factors from cortical bone appeared to modulate bone healing in animals, there has been a search for these mysterious osteoinductive components. Now that their structure has been elucidated, they have been purified and cloned, and are now available for the improvement of bone healing. The best source of BMPs is demineralised bone. This bone allograft is used to achieve greater osteoinductive capacity. But are the actions of procurement, processing, demiAllografts in bone healing ;v. 2.Bone morphogenetic proteinsCollagenBone morphogenetic proteins.Collagen.612.75Phillips Glyn O22968MiAaPQMiAaPQMiAaPQBOOK9910782116903321Bone morphogenetic protein and collagen3692682UNINA