03130nam 2200649Ia 450 991078119760332120230721005643.01-282-05804-5978661205804292-4-068747-5(CKB)2550000000004596(EBL)753786(OCoLC)787842453(SSID)ssj0000300504(PQKBManifestationID)11196186(PQKBTitleCode)TC0000300504(PQKBWorkID)10252680(PQKB)10574004(MiAaPQ)EBC753786(Au-PeEL)EBL753786(CaPaEBR)ebr10277796(CaONFJC)MIL205804(EXLCZ)99255000000000459620081120d2007 uy 0engur|n|---|||||txtccrIPCS mode of action framework[electronic resource] /IPCSGeneva, Switzerland World Health Organizationc20071 online resource (130 p.)Harmonization Project document ;no. 4"IPCS International Programme on Chemical Safety.""This project was conducted within the IPCS project on the Harmonization of Approaches to the Assessment of Risk from Exposure to Chemicals"--P. [i]."Published under the joint sponsorship of the World Health Organization, the International Labour Organization and the United Nations Environment Programme, and produced within the framework of the Inter-Oganization Programme for the Sound Management of Chemicals"--P. [i].92-4-156349-4 Includes bibliographical references.BOOK COVER; TITLE; COPYRIGHT; TABLE OF CONTENTS; FOREWORD; PART 1 IPCS FRAMEWORK FOR ANALYSING THE RELEVANCE OF A CANCER MODE OF ACTION FOR HUMANS AND CASE-STUDIES; PART 2 IPCS FRAMEWORK FOR ANALYSING THE RELEVANCE OF A NON-CANCER MODE OF ACTION FOR HUMANSThe use of structured frameworks in chemical risk assessment promotes transparent harmonized approaches. This book presents two IPCS frameworks originally published in Critical Reviews in Toxicology in a user-friendly large format. Part 1 contains the IPCS Framework for Analysing the Relevance of a Cancer Mode of Action for Humans along with three case studies illustrating its application. Part 2 contains the IPCS Framework for Analysing the Relevance of a Non-Cancer Mode of Action for Humans. The output of a framework analysis is a clear statement of conclusions together with the confidence aHarmonization Project document ;łvno. 4.Hazardous substancesCarcinogensCarcinogenicity testingHealth risk assessmentHazardous substances.Carcinogens.Carcinogenicity testing.Health risk assessment.616.994071MiAaPQMiAaPQMiAaPQBOOK9910781197603321IPCS mode of action framework3689603UNINA