04741nam 2200661Ia 450 991078108610332120230721005628.01-282-44086-197866124408611-84816-257-X(CKB)2550000000003540(EBL)477135(OCoLC)647850790(SSID)ssj0000338410(PQKBManifestationID)11284920(PQKBTitleCode)TC0000338410(PQKBWorkID)10295802(PQKB)10082258(MiAaPQ)EBC477135(WSP)00000710 (Au-PeEL)EBL477135(CaPaEBR)ebr10361671(CaONFJC)MIL244086(EXLCZ)99255000000000354020080718d2009 uy 0engurcuu|||uu|||txtccrHandbook of cardiac stem cell therapy[electronic resource] /edited by Ioannis Dimarakis ... [et al.]London Imperial College Pressc20091 online resource (306 p.)Description based upon print version of record.1-84816-256-1 Includes bibliographical references and index.3. Embryonic Stem Cells and Their Therapeutic Potential Tomo Šari ́c, Shuhua Chen, Naidu Kamisseti, Marcel Halbach, Michael Xavier Doss, Johannes Winkler, Jürgen Hescheler and Agapios Sachinidis Embryonic Stem Cells; ES Cell-Derived Cardiomyocytes; Generation of cardiomyocytes from ES cells; Functional characteristics of ES cell-derived cardiomyocytes; Animal models of cardiomyocytes derived from ES cells; Other Animal Models for ES Cell-Based Therapeutics; Models for neural diseases; Models for therapy for type I diabetes mellitus; Animal models for liver and kidney regenerationCell replacement therapy for other organ systems Barriers to Successful Use of ES Cell-Based Therapies; Ethical concerns; Safety concerns and purity; Rejection of allogeneic cells; Conclusions; References; 4. Umbilical Cord Blood Cells for Cardiac Repair Elad Maor, Arnon Nagler and Jonathan Leor; Introduction; Myocardial Infarction and Heart Failure; Myocardial Regeneration and Cell-Based Therapy; Problems with the Available Cell Sources; The Rationale for Using UCB Progenitor Cells for Myocardial Repair; Data from Animal Models; How Do Cord Blood Cells Repair Ischemic Tissue?Ex vivo Expansion Immunosuppression and Graft versus Host Disease; Summary; References; 5. Amniotic Stem Cells Paolo De Coppi, Anthony Atala and Saverio Sartore; Introduction; Amniocentesis; Differentiated Cells from Amniotic Fluid; Mesenchymal Stem Cells from Amniotic Fluid; Amniotic Fluid Stem Cells; Cell preparation and culture methods; Cell cloning; Telomerase activity; Differentiation potential induction of osteogenic phenotype; Induction of adipogenic lineage; Induction of myogenic phenotype; Induction of endothelial phenotype; Induction of hepatocytes phenotypeInduction of neurogenic phenotype Clonal and proliferative analyses; Conclusion; References; 6. Stem Cell Homing to Injury in Cellular Cardiomyoplasty Adil Al Kindi, Dominique Shum-Tim and Ray Chu-Jeng Chiu; Introduction; The Prelude: Insights from Bone Marrow Transplantation; Animal Studies; The Signaling Molecules; Summary and Conclusions; References; 7. A Molecular Imaging Perspective on Cardiac Repair with Stem Cells Kishore Bhakoo; Introduction; Radionuclide Imaging; Optical Imaging; Ultrasound; MRI Imaging; Intracellular MRI Contrast Agents; MRI Tracking of Stem Cells in the HeartMultimodalityThis book is an impressive compilation of contributions on the hot topic of cardiac stem cell therapy from leading groups all over the world. In the assembly of chapters, a structured approach is adopted; starting from the clinician's perspective, all developments in both the experimental and clinical research areas are covered. This journey will take the reader from the bench-top to the bedside, with all chapters written by leading authorities in their respective fields, including data still in press with medical journals.HeartDiseasesTreatmentStem cellsTransplantationStem cellsHeartDiseasesTreatment.Stem cellsTransplantation.Stem cells.616.1206616/.02774Dimarakis Ioannis1561414MiAaPQMiAaPQMiAaPQBOOK9910781086103321Handbook of cardiac stem cell therapy3828097UNINA