05038nam 2200673Ia 450 991078000900332120230331015621.01-280-18635-697866101863580-309-56748-3(CKB)111069351117044(EBL)3377107(SSID)ssj0001072901(PQKBManifestationID)11594402(PQKBTitleCode)TC0001072901(PQKBWorkID)11165044(PQKB)10575337(MiAaPQ)EBC3377107(Au-PeEL)EBL3377107(CaPaEBR)ebr10068339(CaONFJC)MIL18635(OCoLC)940510430(EXLCZ)9911106935111704419900918d1987 uy 0engur|n|---|||||txtccrAging in today's environment[electronic resource] /Committee on Chemical Toxicity and Aging, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research CouncilWashington, D.C. National Academy Press19871 online resource (234 p.)Committee chairmen: Robert N. Butler and Emil A. Pfitzer.0-309-06227-6 Includes bibliographical references (p. 171-208).AGING In Today's Environment; Copyright; Preface; Contents; Executive Summary; AGING AND NUTRITION; AGING AND SUSCEPTIBILITY TO DISEASE; AGING, DISEASE, PHARMACEUTICAL USE, AND CHEMICAL RESPONSE; AGING AND ENVIRONMENTAL FACTORS; MODEL SYSTEMS FOR RESEARCH; CONCLUSIONS; 1 Aging and Environmental Exposure ; BASIS OF THE SCIENTIFIC PROBLEM; STRUCTURE OF THE REPORT; 2 The Aging Population and the Psychosocial Implications of Aging ; DEMOGRAPHIC CONSIDERATIONS OF AN AGING POPULATION; PSYCHOSOCIAL ENVIRONMENT; 3 Principles of Gerontology ; CONCEPTUAL CONTEXT OF GERONTOLOGY; THEORIES OF AGINGDeterministic TheoriesDevelopmental Switches in Gene Expression; Neuroendocrine-Cascade Theories; Stochastic Theories; Intrinsic Mutagenesis Theory; Protein-Synthesis Error Catastrophe; Free Radicals; Posttranslational Glycation of Proteins and DNA; Thymic Involution as a Pacemaker of Immunosenescence; BIOMARKERS OF AGE OR AGING; ALTERED SUSCEPTIBILITY OF THE AGED; 4 Principles of Toxicology in the Context of Aging ; CHEMICAL FATE AND EFFECT; Absorption; Distribution; Metabolism and Elimination; MECHANISMS OF TOXICITY AT THE MOLECULAR, CELLULAR, AND TISSUE LEVEL; Molecular ActionCellular EffectsEffects at the Tissue Level; PHARMACOGENETICS; BIOLOGIC MARKERS; TOXICITY TESTING; 5 Characteristics of the Environment, Aging, and the Aged ; NUTRITION; Effects of Nutrition on Toxicity; Nutrition and Cancer; Nutrition and Aging; Background and Criteria for Evaluating Aging; Food Restriction; Dietary Protein Intake; Dietary Fat Intake; Dietary Carbohydrate Intake; Dietary Vitamin Intake; Dietary Mineral Intake; Special Dietary Requirements of the Aged; PHARMACEUTICALS; Demographic Considerations; Patterns of Drug Use and Drug Prescribing; Ambulatory PopulationsHospital PopulationsLong-Term-Care Facilities; Medication Compliance in the Elderly; Adverse Drug Reactions; LIFE-STYLE; Deliberate Chemical Exposure; Learned Helplessness; Atrophy of Disuse; Indoor Pollutants; Temperature; Radon; Formaldehyde; Combustion Products; Asbestos; Environmental Tobacco Smoke; Pesticides; 6 Environmental Effects on Age-Associated Diseases and Changes in Organ Function ; DEMOGRAPHICS OF AGE-ASSOCIATED DISEASES; SKIN; VISION; Cataracts; Glaucoma; Diabetic Retinopathy; Aging-Related Macular Degeneration; HEARING; NERVOUS SYSTEM; Changes Associated with AgingInduced Disorders and DiseasesNeurotoxicants; RESPIRATORY SYSTEM; CARDIOVASCULAR SYSTEM; RENAL SYSTEM; IMMUNE SYSTEM; SEXUALITY; ROLE OF ENVIRONMENT IN BONE METABOLISM AND VITAMIN D NUTRITION; 7 Model Systems for the Evaluation of Toxic Agents Affecting Aging or Age-Related Diseases ; CONSIDERATIONS IN CHOOSING AND DESIGNING MODEL SYSTEMS; EXAMPLES OF MODEL SYSTEMS; In Vitro Models; Nonmammalian Animal [Models; Mammalian Models; Epidemiologic Models; LIFE-SPAN MODULATION BY DRUG TREATMENT; 8 Conclusions ; 9 Recommendations ; RESEARCH; EDUCATION; FUNDING AND RESOURCES; ReferencesAppendix Resources for Studying AgingOlder peopleEffect of environment onAgingEnvironmental healthHuman beingsEffect of environment onOlder peopleEffect of environment on.Aging.Environmental health.Human beingsEffect of environment on.612.67Butler Robert N.1927-2010.1526281Pfitzer Emil A1526282MiAaPQMiAaPQMiAaPQBOOK9910780009003321Aging in today's environment3768205UNINA