05082nam 2200769 a 450 991077973740332120230803021130.01-61451-283-310.1515/9781614512837(CKB)2550000001096903(EBL)1037932(OCoLC)851970505(SSID)ssj0000916708(PQKBManifestationID)11471066(PQKBTitleCode)TC0000916708(PQKBWorkID)10894868(PQKB)10758194(MiAaPQ)EBC1037932(DE-B1597)207140(OCoLC)853254573(OCoLC)857081472(DE-B1597)9781614512837(Au-PeEL)EBL1037932(CaPaEBR)ebr10728929(CaONFJC)MIL503437(EXLCZ)99255000000109690320130426d2013 uy 0engur|n|---|||||txtccrConstructing the heritage language learner[electronic resource] knowledge, power, and new subjectivities /[edited by] Neriko Musha Doerr and Kiri LeeBoston De Gruyter Mouton20131 online resource (202 p.)Contributions to the sociology of language,1861-0676 ;v. 103Description based upon print version of record.1-61451-399-6 1-299-72186-9 Includes bibliographical references and index. Frontmatter -- Acknowledgments -- Table of contents -- 1. Introduction: The heritage language learner? -- 2. An emerging field of investigation: Construction of the heritage language learner as a new object of study -- 3. Ethnographic fieldwork at Jackson Japanese Language School -- 4. Betwixt and between Japanese and the heritage language learner of Japanese -- 5. Designing the heritage language learner: Modes of governmentality in the classroom -- 6. Defining the heritage language learner -- 7. Shifting frames of reference: JJLS, AP, heading college, and construction of the Japanese-as-aheritage- language learner -- 8. Adjusting the Jackson Course -- 9. Implications and departure -- Appendix 1: First Questionnaires for Parents -- Appendix 2: Second Questionnaires for Parents -- Appendix 3: First Questionnaires for Students -- Appendix 4: Second Questionnaires for Students -- Appendix 5: Questionnaires for Teachers -- Appendix 6: Questionnaires for Parents of Students Who Were Leaving or Had Left JJLS -- Appendix 7: Questionnaires for Students Who Were Leaving or Had Left JJLS -- Appendix 8: Summary of Student Interviews and Profiles -- Appendix 9: Glossary of Japanese Terms -- References -- IndexHeritage language education is a relatively new field developed as "heritage" has become an important trope of belonging, legitimacy and commodification. Many recent studies treat the "heritage language learner" as an objective category. However, it is a social construct, whose meaning is contested by researchers, school administrators and the students themselves. Based on ethnographic fieldwork in 2007-2011 at a weekend Japanese language school in the United States, this monograph investigates the construction of the heritage language learner at the intersections of the knowledge-power complex, ideologies of language and national belonging, and politics of schooling. It examines the ways individuals become, resist and negotiate their new subjectivity as heritage language learners through becoming objects of study, being caught in nationalist aspirations and school politics regarding what to teach to whom, and negotiating with peers with various linguistic proficiency and family backgrounds. The volume proposes a new approach to view the notion of heritage language learner as a site of negotiation regarding the legitimate knowledge of language and ways of belonging, while offering practical suggestions for schools. Contributions to the sociology of language ;103.Language and languagesStudy and teachingUnited StatesSecond language acquisitionLanguage teachersTraining ofUnited StatesJapanese languageStudy and teachingForeign speakersHeritage Language School.Japanese.Language Education.Sociolinguistics.Subjectivity.Language and languagesStudy and teachingSecond language acquisition.Language teachersTraining ofJapanese languageStudy and teachingForeign speakers.495.680071/073Doerr Neriko, 1499441Doerr Neriko Musha1967-1499442Lee Kiri1499443MiAaPQMiAaPQMiAaPQBOOK9910779737403321Constructing the heritage language learner3725470UNINA04443nam 2200469z- 450 991022734610332120210211(CKB)4100000000883872(oapen)https://directory.doabooks.org/handle/20.500.12854/42247(oapen)doab42247(EXLCZ)99410000000088387220202102d2017 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierBiomarkers in Drug HypersensitivityFrontiers Media SA20171 online resource (104 p.)Frontiers Research Topics2-88945-226-3 Biomarkers, especially those based on pharmacogenomics testing, have proved to be extremely useful for type A adverse drug reactions. Clinical practice guidelines based on biomarker testing are presently being developed and updated for type A adverse drug reactions. In contrast, little attention has been paid to the potential use of biomarkers in type B adverse reactions, characterized by the occurrence of reactions not directly related to the pharmacological properties of the drug. Drug-induced hypersensitivity belongs to those type B reactions. Drug-induced hypersensitivity reactions involve complex mechanisms that include, among others, the metabolic activation and haptenization of drug metabolites. Hence, factors that influence the pharmacokinetics of drug and metabolites may contribute to the development of some drug-induced hypersensitivity reactions. This implies that processes such as ADME (absorption, distribution, metabolism and excretion) that are typically involved in type A adverse drug reactions, may have a role in hypersensitivity reactions too. In addition to metabolic activation, several signal transduction pathways participate and modulate the development and the clinical presentation of drug hypersensitivity. The diverse mechanisms underlying such drug-hypersensitivity reactions lead to four major groups of reactions according to the Gell and Coombs classification: immediate, cytotoxic, immune complex and delayed. The enormous complexity of drug-hypersensitivity reactions is a consequence of the variety of mechanisms involved, which may be related, among others, to drug metabolism, generation of antigenic signals, stimulation and maturation of dendritic cells, presentation of haptens and mechanisms of cytotoxicity. In addition, a plethora of possible clinical presentations exists, including urticaria, angioedema, anaphylaxis, cytopenias, nephritis, serum sickness, vasculitis, contact dermatitis, drug rash, eosinophilia and systemic symptoms, Stevens-Johnson syndrome, toxic epidermal necrolysis and acute generalized exanthematous pustulosis. The rapid progress in the field in recent years indicates that the combination of several disciplines is essential to understand the mechanisms involved in this particular, and not completely understood, type of adverse drug reactions. The objective of this Research Topic is to present insights obtained from both basic and clinical scientists, which may include studies related to the identification, validation, refinement and clinical implementation of biomarkers for drug-induced hypersensitivity. The Topic aims to include recent findings related, but not limited to, potential phenomic, genomic, proteomic, metabolomic and signal transduction biomarkers. These biomarkers could eventually be used in clinical practice and/or these might contribute, as a proof of concept, to our understanding of the complex events leading to drug hypersensitivity reactions. In addition the Topic will cover recent developments and methodological advances in the diagnosis, prevention and therapeutic management of drug-induced hypersensitivity.Pharmacologybicsscbiomarkersdrugdrug metabolismgenotypinghaptenizationhypersensitivitymodelsphenotypingPharmacologyEmanuela Corsiniauth1312093Silvia SelinskiauthJose A. G. AgundezauthElena Garcia-MartinauthKlaus GolkaauthBOOK9910227346103321Biomarkers in Drug Hypersensitivity3030677UNINA