03584oam 2200469 450 991013679920332120230621135411.09782889197507 (ebook)(CKB)3710000000631130(oapen)https://directory.doabooks.org/handle/20.500.12854/42834(EXLCZ)99371000000063113020191103c2016uuuu uu 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierCD1- and MR1-restricted T cells in antimicrobial immunity[electronic resource] /edited by S.M. Mansour Haeryfar and Thierry MallevaeyFrontiers Media SA2016France :Frontiers Media SA,20151 online resource (189 pages) colour illustrationsFrontiers Research TopicsIncludes bibliographical references.Cell-mediated immunity to extracellular and intracellular microbes has been traditionally linked to CD4+ and CD8+ T cells that recognize pathogen-derived peptides in the context of major histocompatibility complex (MHC) class II and class I molecules, respectively. Recent progress in our understanding of early host defense mechanisms has brought ‘unconventional’, innate-like T cells into the spotlight. These are a heterogeneous population of non-MHC-restricted T cells that exhibit ‘memory-like’ properties and mount emergency responses to infection. They may directly detect and destroy infected cells, but are best known for their ability to regulate downstream effector cells including but not limited to conventional T cells. Innate-like T cells include among others CD1-restricted natural killer T (NKT) cells and MR1-restricted mucosa-associated invariant T (MAIT) cells. NKT cells recognize lipid antigens, and MAIT cells were recently demonstrated to respond to microbe-derived vitamin B metabolites. However, much remains to be learned about the antigen specificity range of these cells, their activation mode and their true potentials in immunotherapeutic applications. Like in many other areas of biology, uncertainties and controversies surrounding these cells and some of the experimental models, techniques and reagents employed to study them have brought about excitement and sometimes hot debates. This Special Topic was launched to provide updated reviews on protective and/or pathogenic roles of NKT and MAIT cells during infection. Leading experts discuss current controversies, pressing questions and the challenges that lie ahead for the advancement of this intriguing and rapidly evolving area of immunology. Unlike MHC, CD1 and MR1 display very limited polymorphism. Therefore, NKT and MAIT cells may be considered attractive targets for various diseases in diverse human populations. The potential benefits of NKT cell- and MAIT cell-based vaccination and treatment strategies in infectious diseases is an important subject that is also covered in this Topic.Cellular biologyCD1MAIT cellinfectionimmunopathologymicrobesinflammationinnate-like T cellsimmunityNKT cellMR1Cellular biology.S.M. Mansour Haeryfarauth1364000Thierry MallevaeyauthUkMaJRU9910136799203321CD1- and MR1-restricted T cells in antimicrobial immunity3385073UNINA04308nam 2200649Ia 450 991077914110332120230124183647.00-7914-7713-4(CKB)2550000000104501(EBL)3407501(SSID)ssj0000721446(PQKBManifestationID)11384238(PQKBTitleCode)TC0000721446(PQKBWorkID)10687104(PQKB)10030077(MiAaPQ)EBC3407501(Au-PeEL)EBL3407501(CaPaEBR)ebr10575927(OCoLC)802049423(EXLCZ)99255000000010450120080416d2009 ub 0engurcn|||||||||txtccrThe passionate empiricist[electronic resource] the eloquence of John Quincy Adams in the service of science /Marlana PortolanoAlbany State University of New York Pressc20091 online resource (249 p.)Description based upon print version of record.0-7914-7699-5 Includes bibliographical references (p. 221-227) and index.""The Passionate Empiricist""; ""Contents""; ""Preface""; ""Acknowledgments""; ""1. A Classical Voice for American Science""; ""2. An American Cicero""; ""ADAMS THE PROFESSOR OF RHETORIC""; ""THE LECTURES ON RHETORIC: AN OUTLINE OF ADAMS'S THEORY""; ""COMPETING RHETORICAL TEACHINGS IN ADAMS'S TIME""; ""TWENTIETH-CENTURY RHETORICAL THEORY:AN AID FOR CONTEMPORARY READERS""; ""3.Toward a Democratic Science:Institution-Building and the Statesman Orator""; ""ADAMS'S EARLY DEVELOPMENT AS AN ORATOR FOR DEMOCRATIC SCIENCE""; ""THE PRESIDENCY AS PULPIT FOR SCIENCE""""APPEALING TO THE AUDIENCE: EARLY AMERICAN ATTITUDES TOWARD SCIENCE""""4. Increase and Diffusion of Knowledge:Setting the Stage for the Smithsonian Debate""; ""THE QUESTION OF JAMES SMITHSON'S INTENTIONS""; ""THE SMITHSONIAN AND THE ETHOS OF SCIENTIFIC DISCOVERY""; ""EARLY SCIENTIFIC INSTITUTIONS AS MODELS IN DELIBERATIVE RHETORIC""; ""THE SMITHSONIAN AS LOCUS FOR COMMON KNOWLEDGE""; ""AN IMPERIOUS AND INDISPENSABLE OBLIGATION""; ""THE STATE OF THE CONTROVERSY""; ""5. Adams's Arguments in the Smithsonian Debate: A Rhetorical Analysis""""AN INVENTIVE STAGE: LETTERS, LEARNED ADVICE,AND PRIVATE CONVERSATIONS""""ASHER ROBBINS AND THE NATIONAL UNIVERSITY PLAN""; ""ADAMS'S REFUTATIONS AND HIS FIRST ARGUMENTS FOR AN OBSERVATORY""; ""TWO PARTICULAR AUDIENCES AND ADAMS'S ROLE AS IMPARTIAL JUDGE""; ""FINANCIAL DELAYS TO ACTION: CATCH THE BEAR BEFORE YOU SELL HIS SKIN""; ""RESISTANCE TO ARGUMENTATION""; ""ARGUMENTS FOR A NATURAL HISTORY MUSEUM AND THE AGRICULTURAL INFLUENCE""; ""THE GRAND LIBRARY PLAN""; ""COMPROMISE""; ""6. The Queen of Sciences and Her Democratic Champion: Adams's Promotion of Astronomy""""ADAMS'S CONGRESSIONAL ARGUMENTS FOR AN OBSERVATORY""""ADAMS'S PUBLIC SPEAKING TOURS ON ASTRONOMY""; ""7.Invention and Discovery, Rhetorically Speaking""; ""APPENDIX A. The Will of James Smithson""; ""APPENDIX B. An Act to Establish the Smithsonian Institution as it Passed into Law on August 10, 1846""; ""Notes""; ""Bibliography""; ""Index""; ""A""; ""B""; ""C""; ""D""; ""E""; ""F""; ""G""; ""H""; ""I""; ""J""; ""K""; ""L""; ""M""; ""N""; ""O""; ""P""; ""Q""; ""R""; ""S""; ""T""; ""V""; ""W""EloquenceCase studiesSciencePolitical aspectsUnited StatesHistoryScienceSocial aspectsUnited StatesHistoryScience and stateUnited StatesHistoryRhetoricPolitical aspectsUnited StatesHistoryUnited StatesPolitics and government1815-1861United StatesIntellectual life1783-1865EloquenceSciencePolitical aspectsHistory.ScienceSocial aspectsHistory.Science and stateHistory.RhetoricPolitical aspectsHistory.973.5/5092Portolano Marlana1519669MiAaPQMiAaPQMiAaPQBOOK9910779141103321The passionate empiricist3757907UNINA