05570nam 2200745 a 450 991077870380332120230331015407.01-280-21225-X97866102122550-309-54356-80-585-12524-4(CKB)111004366659530(EBL)3376920(SSID)ssj0000204431(PQKBManifestationID)11954473(PQKBTitleCode)TC0000204431(PQKBWorkID)10174978(PQKB)10716050(MiAaPQ)EBC3376920(Au-PeEL)EBL3376920(CaPaEBR)ebr10062761(CaONFJC)MIL21225(OCoLC)923266968(EXLCZ)9911100436665953019900501d1990 uy 0engur|n|---|||||txtccrModern methods of clinical investigation[electronic resource] /Annetine C. Gelijns, editor ; Committee on Technological Innovation in Medicine, Institute of MedicineWashington, D.C. National Academy Press19901 online resource (244 p.)Medical innovation at the crossroads ;v. 1Proceedings of a workshop held on May 3-4, 1989, supported by the Howard Hughes Medical Institute and the National Center for Health Services Research of the Department of Health and Human Services (grant 5 RO9 HS055 26 02).Includes index.0-309-04286-0 Includes bibliographical references.""Modern Methods of Clinical Investigation""; ""Copyright""; ""Acknowledgments""; ""Preface""; ""Contents""; ""List of Abbreviations""; ""1 Medical Technology Development: An Introduction to the Innovation-Evaluation Nexus ""; ""PUTTING CLINICAL EVALUATION IN CONTEXT""; ""ISSUES IN INNOVATION AND EVALUATION: THE CASE OF STABLE ANGINA PECTORIS""; ""Beta-Blockers""; ""Coronary Artery Bypass Grafting""; ""PTCA Catheter Equipment""; ""Evaluative Shortcomings in Technology Development""; ""IMPROVING THE INNOVATION-EVALUATION NEXUS""; ""The Selection of Endpoints in Evaluative Research""""The Selection of Methods for Clinical Investigation""""Policy Mechanisms for Improving Developmental Decision Making""; ""REFERENCES""; ""2 The Selection of Endpoints in Evaluative Research ""; ""SURROGATE VERSUS CLINICAL ENDPOINTS""; ""CLINICAL ENDPOINTS""; ""SURROGATE ENDPOINTS""; ""REFERENCES""; ""3 Advances in Health Status Measurement: The Potential to Improve Experimental and Non-Experimental Data Collection""; ""THE CONDUCT OF CLINICAL TRIALS""; ""MEASUREMENT OF QUALITY OF LIFE AND OF HEALTH STATUS""; ""INCLUSION OF QUALITY OF LIFE AND HEALTH STATUS MEASURES IN CLINICAL TRIALS""""FOUR PROBLEMS REGARDING THE MEASUREMENT OF HEALTH STATUS IN CLINICAL TRIALS""""REFERENCES""; ""4 What Is Outcomes Research? ""; ""WHICH RATE IS RIGHT?""; ""ENGAGING PATIENTS IN THE DECISION PROCESS""; ""EXTENDING ASSESSMENT TO ALL RELEVANT TREATMENT THEORIES""; ""THE EVALUATIVE CLINICAL SCIENCES AND THE FUTURE OF MEDICINE""; ""REFERENCES""; ""5 Strengths and Weaknesses of Health Insurance Data Systems for Assessing Outcomes""; ""STRENGTHS""; ""System-Wide, Population-Based Data""; ""Efficacy versus Effectiveness""; ""Large Numbers and Time Series""; ""Events Unaffected by Recall""""Unobtrusive Nature""""Multiple Comparisons""; ""Design Flexibility""; ""Potential for Multiple Projects""; ""Focus on Risks""; ""Clinical Decision Making""; ""WEAKNESSES""; ""Structural Limitations""; ""Bias Due to Reporting and Coding""; ""Bias Due to Differential Contact""; ""Benefits of Treatment""; ""CONTROVERSIAL AREAS""; ""Risk Adjustment""; ""Outcome Measures""; ""EXPANDING DATA BASES""; ""Record Linkage""; ""Primary Data Collection""; ""DISCUSSION""; ""REFERENCES""; ""6 Prescription-Event Monitoring: An Example of Total Population Post-Marketing Drug Surveillance """"""THE NUMBERS GAME""""""VOLUNTARY REPORTING SYSTEMS""; ""POST-MARKETING SURVEILLANCE""; ""PRESCRIPTION-EVENT MONITORING""; ""COMPARATIVE STUDIES OF NSAIDS""; ""POST-MARKETING SURVEILLANCE AND POST-MARKETING CLINICAL TRIALS""; ""CONCLUSION""; ""REFERENCES""; ""7 The Role of Decision Analysis in the Translation of Research Findings into Clinical Practice ""; ""DECISION ANALYSIS AT THE INTERFACE BETWEEN CLINICAL INVESTIGATION AND CLINICAL PRACTICE""; ""WHAT DECISION ANALYSIS IS""; ""THE LIMITATIONS OF DECISION ANALYSIS: WHAT IT IS NOT""""SETTING PRIORITIES AND PARAMETERS FOR CLINICAL INVESTIGATION""Medical innovation at the crossroads ;v. 1.Medical technologyEvaluationCongressesMedical innovationsEvaluationCongressesMedical careTechnological innovationsCongressesMeta-analysisCongressesMedical technologyEvaluationMedical innovationsEvaluationMedical careTechnological innovationsMeta-analysis610/.72Gelijns Annetine1528675Institute of Medicine (U.S.).Committee on Technological Innovation in Medicine.Howard Hughes Medical Institute.National Center for Health Services Research.MiAaPQMiAaPQMiAaPQBOOK9910778703803321Modern methods of clinical investigation3845350UNINA