05060nam 2200661Ia 450 991077861120332120230607203416.00-309-17139-31-280-18509-097866101850920-309-56761-0(CKB)110986584753278(EBL)3377205(SSID)ssj0000279270(PQKBManifestationID)11227266(PQKBTitleCode)TC0000279270(PQKBWorkID)10260477(PQKB)10422544(MiAaPQ)EBC3377205(Au-PeEL)EBL3377205(CaPaEBR)ebr10068442(CaONFJC)MIL18509(OCoLC)923269014(EXLCZ)9911098658475327820010810d2001 uy 0engur|n|---|||||txtccrEvaluating chemical and other agent exposures for reproductive and developmental toxicity[electronic resource] /Subcommittee on Reproductive and Developmental Toxicology, Committee on Toxicology, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research CouncilWashington, D.C. National Academy Pressc20011 online resource (262 p.)Compass seriesDescription based upon print version of record.0-309-07316-2 Includes bibliographical references (p. 92-114).""EVALUATING CHEMICAL AND OTHER AGENT EXPOSURES FOR REPRODUCTIVE AND DEVELOPMENTAL TOXICITY""; ""Copyright""; ""Preface""; ""Contents""; ""Abbreviations""; ""EVALUATING CHEMICAL AND OTHER AGENT EXPOSURES FOR REPRODUCTIVE AND DEVELOPMENTAL TOXICITY""; ""Summary""; ""CONCLUSIONS AND RECOMMENDATIONS""; ""Evaluative Process""; ""Assessing the Available Data""; ""Integration of Toxicity and Exposure Information""; ""Insufficient Data Sets""; ""Application of the Evaluative Process""; ""Sources of Information""; ""Research Recommendations""; ""1 Introduction ""; ""SUBCOMMITTEE'S TASK""""ORGANIZATION OF THE REPORT""""2 The Evaluative Process: Part I. Assessing the Available Data ""; ""PRINCIPLES AND OBJECTIVES""; ""Use of Data and Judgment""; ""Weight of Evidence""; ""Threshold Assumption""; ""Narrative Statement""; ""Certainty""; ""Use All Relevant, Acceptable Data""; ""Qualities and Limitations of Reproductive and Developmental Toxicity Studies""; ""Characterizing Data""; ""Expert Review Team""; ""GENERAL DESCRIPTION""; ""DETAILS OF THE EVALUATIVE PROCESS""; ""Exposure Data""; ""General Toxicological and Biological Parameters""; ""Chemistry""; ""Basic Toxicity""""Acute Studies""""Repeated-Dose Studies""; ""Genetic Toxicity""; ""Pharmacokinetics""; ""Reproductive and Developmental Toxicity""; ""Human Data""; ""Weighing the Evidence""; ""Case Reports and Clinical Series""; ""Assessing Causality in Human Studies""; ""Experimental Animal Toxicity""; ""Utility and Limitations""; ""Adverse Effect""; ""3 The Evaluative Process: Part II. Integration of Toxicity and Exposure Information ""; ""INTERPRETATION OF TOXICITY DATA""; ""Default Assumptions To Be Considered in Assessing Reproductive and Developmental Toxicity Risk""; ""Absorption""""Cross-Species Extrapolation""""Exposure Duration""; ""Windows of Vulnerability""; ""Additivity""; ""QUANTITATIVE EVALUATION""; ""Identification of the NOAEL and LOAEL""; ""Calculation of the Benchmark Dose""; ""Duration Adjustment""; ""Uncertainty Factors""; ""Calculation of the Unlikely Effect Level""; ""Calculation of the Margin of Exposure (MOE)""; ""Assessing a Degree of Concern""; ""Application of Reproductive and Developmental Toxicity Data to Various Exposure Scenarios""; ""Critical Data Needs""; ""SUMMARY""; ""4 Incomplete or Insufficient Data Sets """"PRINCIPLES TO MINIMIZE RISK""""PRACTICAL APPLICATION""; ""REDUCING UNCERTAINTY""; ""5 Recommendations ""; ""GENERAL RECOMMENDATIONS""; ""RESEARCH RECOMMENDATIONS""; ""References""; ""Appendixes""; ""Appendix A Application of the Recommended Evaluative Process to Specific Chemicals ""; ""JP-8 JET FUEL""; ""Exposure Data""; ""General Toxicological and Biological Parameters""; ""Lethality""; ""Acute Studies""; ""Human Studies""; ""Experimental Animal Studies""; ""Repeated-Dose Studies""; ""Human Studies""; ""Experimental Animal Studies""; ""Cancer""; ""Genetic Toxicity""""Disposition and Pharmacokinetics""Compass series (Washington, D.C.)Reproductive toxicologyDevelopmental toxicologyToxicity testingReproductive toxicology.Developmental toxicology.Toxicity testing.616.6/5071MiAaPQMiAaPQMiAaPQBOOK9910778611203321Evaluating chemical and other agent exposures for reproductive and developmental toxicity3768953UNINA