03089nam 22006254a 450 991077782350332120230721031457.00-19-770667-31-281-16268-X0-19-972006-11-4294-8700-3(CKB)1000000000473235(StDuBDS)AH24087204(SSID)ssj0000154076(PQKBManifestationID)11163862(PQKBTitleCode)TC0000154076(PQKBWorkID)10406560(PQKB)11314794(Au-PeEL)EBL1665564(CaPaEBR)ebr10180668(CaONFJC)MIL116268(OCoLC)923707823(MiAaPQ)EBC1665564(EXLCZ)99100000000047323520060324d2007 uy 0engurcn|||||||||txtccrFemales are mosaics[electronic resource] X inactivation and sex differences in disease /Barbara R. MigeonOxford ;New York Oxford University Press20071 online resource (xi, 271 p., [8] p. of plates )ill. (some col.)Formerly CIP.Uk0-19-518812-8 Includes bibliographical references (p. 241-257) and index.'Females are Mosaics' focuses on the X chromosome as a key to female development and the role of X-related factors in the etiology of sex differences in human disease.Women can be described as genetic mosaics because they have two distinctly different types of cells throughout their bodies. Unlike males, who have one X chromosome (inherited from their mother), females have two X chromosomes in every cell (one from each parent). The father's copy works in some cells, while the mother's copy works in others. These two X chromosomes often function differently, especially if one carries a defective gene. Much has been written about the Y chromosome and its role in inducing maleness. This will be the first book about the X chromosome as a key to female development and the role of X-related factors in the etiology of sex differences in human disease. Barbara Migeon, from the renowned McKusick-Nathan Institute at Johns Hopkins, is a major figure in clinical genetics and is eminently qualified to write this book, and she writes clearly and effectively. She describes both the underlying molecular mechanisms and the remarkable genetic consequences of X inactivation and its role in determining the biological concepts characteristic of women.X chromosomeMosaicismSex determination, GeneticSex-linkage (Genetics)X chromosome.Mosaicism.Sex determination, Genetic.Sex-linkage (Genetics)616/.042Migeon Barbara R1472956MiAaPQMiAaPQMiAaPQBOOK9910777823503321Females are mosaics3686000UNINA