05041nam 2200625Ia 450 991077758420332120230421044936.0(CKB)1000000000450801(EBL)3377315(SSID)ssj0000249201(PQKBManifestationID)11216392(PQKBTitleCode)TC0000249201(PQKBWorkID)10205604(PQKB)10576706(OCoLC)58594839(MiAaPQ)EBC3377315(EXLCZ)99100000000045080119941122d1994 uy 0engur|n|---|||||txtccrSpacecraft maximum allowable concentrations for selected airborne contaminantsVolume 1[electronic resource] /Subcommittee on Spacecraft Maximum Allowable Concentrations, Committee on Toxicology, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research CouncilWashington, D.C. National Academy Press19941 online resource (235 p.)"The project was supported by the National Aeronautics and Space Administration grant no. NAGW-2239."0-309-57222-3 Includes bibliographical references.""Spacecraft Maximum Allowable Concentrations for Selected Airborne Contaminants""; ""Copyright""; ""Preface""; ""Contents""; ""Spacecraft Maximum Allowable Concentrations for Selected Airborne Contaminants""; ""INTRODUCTION""; ""SUMMARY OF REPORT ON GUIDELINES FOR DEVELOPING SMACS""; ""REVIEW OF SMAC REPORTS""; ""REFERENCES""; ""Appendix A Executive Summary of Guidelines for Developing Spacecraft Maximum Allowable Concentration for Space Station�""; ""EXECUTIVE SUMMARY: SPACECRAFT MAXIMUM ALLOWABLE CONCENTRATIONS FOR SPACE STATION CONTAMINANTS""""ENVIRONMENTAL CONTROL AND LIFE-SUPPORT SYSTEM""""MODIFICATION OF CONTAMINANT TOXICITY BY ENVIRONMENTAL FACTORS""; ""SOURCES AND TYPES OF DATA FOR ESTABLISHMENT OF SMACS""; ""Chemical-Physical Characteristics of Toxicants""; ""In Vitro Toxicity Studies""; ""Animal Toxicity Studies""; ""Clinical and Epidemiological Observations""; ""Pharmacokinetics and Metabolism""; ""Biological Markers""; ""RISK ASSESSMENT (DEVELOPMENT OF EXPOSURE CRITERIA)""; ""ISSUES IN MAKING RECOMMENDATIONS FOR THE ESTABLISHMENT OF SMACS""""Appendix B Reports on Spacecraft Maximum Allowable Concentrations (SMACs) for Selected Airborne Contaminants""""B1 ACETALDEHYDE""; ""PHYSICAL AND CHEMICAL PROPERTIES""; ""OCCURRENCE AND USE""; ""PHARMACOKINETICS AND METABOLISM""; ""TOXICITY SUMMARY""; ""Acute Toxicity""; ""Mucosal Irritation""; ""Miscellaneous Mucosal Effects""; ""Lethality""; ""Subchronic and Chronic Toxicity""; ""Nasal Toxicity""; ""Pulmonary and Renal Toxicity""; ""Carcinogenicity""; ""Genotoxicity""; ""Reproductive and Developmental Toxicity""; ""Synergistic Effects""; ""RATIONALE""; ""Carcinogenicity""""Mucosal Irritation""""The Establishment of SMACs""; ""REFERENCES""; ""B2 AMMONIA""; ""PHYSICAL AND CHEMICAL PROPERTIES""; ""OCCURRENCE AND USE""; ""PHARMACOKINETICS AND METABOLISM""; ""TOXICITY SUMMARY""; ""Mechanisms of Tissue Injuries""; ""Mucosal Irritation in Naive Subjects""; ""Mucosal Irritation in Adapted Subjects""; ""Mucosal Irritation in Subjects Of Unknown Adaptation Status""; ""Toxic Effects of Massive Exposures""; ""Animal Models of Ammonia's Respiratory Damage""; ""Metabolic Acidosis""; ""RATIONALE""; ""1-h SMAC and 24-h SMAC""; ""7-d SMAC""; ""30-d SMAC and 180-d SMAC""""REFERENCES""""B3 CARBON MONOXIDE""; ""PHYSICAL AND CHEMICAL PROPERTIES""; ""OCCURRENCE AND USE""; ""PHARMACOKINETICS""; ""TOXICITY SUMMARY""; ""Acute Toxicity""; ""Adaptation""; ""Subchronic and Chronic Toxicity""; ""Synergistic Effects""; ""RATIONALE""; ""1-h SMAC""; ""24-h SMAC""; ""7-d SMAC""; ""30-d SMAC and 180-d SMAC""; ""1-h and 24-h SMACs Immediately Following CO Exposure""; ""REFERENCES""; ""B4 FORMALDEHYDE""; ""PHYSICAL AND CHEMICAL PROPERTIES""; ""OCCURRENCE AND USE""; ""PHARMACOKINETICS AND METABOLISM""; ""TOXICITY SUMMARY""; ""Acute Toxicity""""Subchronic and Chronic Toxicity""Space cabin atmospheresSpace vehiclesAir pollutionSpace vehiclesAir qualityStandardsSpace vehiclesContaminationSpace vehiclesEnvironmental aspectsToxicologyResearchUnited StatesSpace cabin atmospheres.Space vehiclesAir pollution.Space vehiclesAir qualityStandards.Space vehiclesContamination.Space vehiclesEnvironmental aspects.ToxicologyResearch629.477MiAaPQMiAaPQMiAaPQBOOK9910777584203321Spacecraft maximum allowable concentrations for selected airborne contaminants3687714UNINA