04416nam 2200517Ia 450 991077742000332120230421044922.0(CKB)1000000000450644(EBL)3377508(SSID)ssj0000260709(PQKBManifestationID)11191950(PQKBTitleCode)TC0000260709(PQKBWorkID)10223919(PQKB)11545860(OCoLC)567831797(MiAaPQ)EBC3377508(EXLCZ)99100000000045064419860313d1996 uy 0engur|n|---|||||txtccrToxicity of alternatives to chlorofluorocarbons[electronic resource] HFC-134a and HCFC-123 /Subcommittee to Review Toxicity of Alternatives to ChlorofluorocarbonsWashington, D.C. National Academy Press Available from [the] Committee on Human Rights19961 online resource (130 p.)Description based upon print version of record.0-309-57201-0 ""Toxicity of Alternatives to Chlorofluorocarbons: HFC-134a and HCFC-123""; ""Copyright""; ""Preface""; ""Contents""; ""Executive Summary""; ""ASSESSMENT OF MODEL FOR CARDIAC SENSITIZATION""; ""EXPOSURE GUIDANCE LEVELS FOR HFC-134A""; ""EXPOSURE GUIDANCE LEVEL FOR HCFC-123""; ""1 Introduction ""; ""STATEMENT OF TASK""; ""DEFINITIONS""; ""Emergency Exposure Guidance Level""; ""Continuous Exposure Guidance Level""; ""STRUCTURE OF THE REPORT""; ""2 Evaluation of the Dog Cardiac Sensitization Test ""; ""INTRODUCTION""; ""MECHANISM OF ACTION FOR CHEMICALLY INDUCED ARRHYTHMIAS""""PROTOCOL FOR A CARDIAC SENSITIZATION SCREENING STUDY""""CARDIAC SENSITIZATION EXPERIMENTS INVOLVING SELECTED HALOCARBONS""; ""CONCLUSION""; ""REFERENCES""; ""3 Exposure Guidance Levels for Hydrofluorocarbon-134a ""; ""INTRODUCTION""; ""BACKGROUND INFORMATION""; ""Physical and Chemical Properties""; ""Occurrence and Use""; ""TOXICOKINETICS""; ""TOXICITY INFORMATION""; ""Acute Toxicity""; ""Cardiac Sensitization""; ""Subacute Toxicity""; ""Subchronic Toxicity""; ""Developmental Toxicity""; ""Reproductive Toxicity""; ""Genotoxicity""; ""Carcinogenicity""; ""SUMMARY""""RECOMMENDATIONS FOR EXPOSURE GUIDANCE LEVELS""""REFERENCES""; ""4 Exposure Guidance Levels for Hydrochlorofluorocarbon-123 ""; ""INTRODUCTION""; ""RECOMMENDATIONS FOR EXPOSURE GUIDANCE LEVELS""; ""REFERENCES""; ""Appendix A""; ""SUPPORTING DOCUMENTATION FOR THE EXPOSURE GUIDANCE LEVELS FOR HYDROCHLOROFLUOROCARBON-123""; ""BACKGROUND INFORMATION""; ""Physical and Chemical Properties""; ""Occurrence and Use""; ""TOXICOKINETICS""; ""TOXICITY INFORMATION""; ""Effects in Humans""; ""Effects in Animals""; ""Single-Exposure Studies""; ""Repeat-Exposure Studies""; ""EXPOSURE ASSESSMENT""""RECOMMENDATIONS FOR EXPOSURE GUIDANCE LEVEL""""REFERENCES""; ""ATTACHMENT 1 MATERIAL SAFETY DATA SHEET""; ""ATTACHMENT 2 HALOTHANE""; ""BACKGROUND INFORMATION""; ""Physical and Chemical Properties""; ""Occurrence and Use""; ""ACUTE TOXICITY INFORMATION""; ""Acute Toxicity and CNS Depression""; ""Cardiac Sensitization""; ""Effects in Humans""; ""Malignant Hyperthermia""; ""Hepatotoxicity""; ""DISCUSSION""; ""HCFC-123 AND Halothane Comparison""; ""Acute Toxicity and CNS Depression""; ""Cardiac Sensitization""; ""Malignant Hyperthermia""; ""Hepatotoxicity""; ""REFERENCES""""ATTACHMENT 3 SUMMARY OF TOXICITY STUDIES OF HCFC-123""""I. ANIMAL STUDIES: SINGLE EXPOSURE""; ""II. ANIMAL STUDIES: REPEAT EXPOSURE""; ""III. REFERENCES""; ""ATTACHMENT 4 SUMMARY OF ACUTE PHARMACOKINETIC STUDY OF HCFC-123 IN DOGS BY INHALATION""; ""OBJECTIVE""; ""MATERIALS AND METHODS""; ""Exposure System""; ""Blood and Tissue Sampling""; ""Analysis of Blood and Tissue Samples""; ""RESULTS""; ""DISCUSSION""AirPollutionChlorofluorocarbonsEnvironmental aspectsAirPollution.ChlorofluorocarbonsEnvironmental aspects.547.01046National Academy of Sciences (U.S.).Subcommittee to Review Toxicity of Alternatives to Chlorofluorocarbons.MiAaPQMiAaPQMiAaPQBOOK9910777420003321Toxicity of alternatives to chlorofluorocarbons3776458UNINA