06367nam 2200769 450 991015363570332120230525195533.01-61504-733-610.4199/C00144ED1V01Y201610ISP067(CKB)3710000000962284(MiAaPQ)EBC4744545(CaBNVSL)swl00406953(OCoLC)964085804(MOCL)201610ISP067(EXLCZ)99371000000096228420161206d2017 fy 0engurcnu||||||||rdacontentrdamediardacarrierMolecular mechanisms of body water homeostasis /Carolyn M. Ecelbarger, Dharmendra Kumar Chaudhary, Hwal Lee, Swasti Tiwari[San Rafael, California] :Morgan & Claypool,2017.1 online resource (112 pages) color illustrationsColloquium series on integrated systems physiology,2154-5626 ;# 68Part of: Colloquium digital library of life sciences.1-61504-732-8 Includes bibliographical references (pages 75-97).1. Water, water everywhere -- 1.1 Chapter overview -- 1.2 Body water composition -- 1.2.1 Changes in water homeostasis over the lifespan -- 1.2.2 Body water intake requirements -- 1.3 Measurement of total body water (TBW) -- 1.3.1 Body water compartmentalization -- 1.4 Dehydration -- 1.4.1 Exercise and water requirements -- 1.5 Environmental modulators of body water composition -- 1.5.1 High altitude -- 1.5.2 Extremes in temperature or humidity -- 1.5.3 Dietary alterations --2. The brain, AVP, and water balance -- 2.1 Chapter overview -- 2.2 The brain -- 2.3 Vasopressin and related neuropeptides -- 2.3.1 Regulation of vasopressin production and release -- 2.4 Vasopressin receptors -- 2.4.1 Receptor cloning -- 2.4.2 Receptor activation and signaling -- 2.4.3 Receptor localization -- 2.5 Vasopressin actions -- 2.5.1 Vasopressin and glomerular filtration rate (GFR) -- 2.5.2 Vasopressin and blood pressure control -- 2.5.2.1 AVPR2 are coupled to nitric oxide generation -- 2.5.2.2 Hypertension may correlate with urinary concentrating ability --3. Renal control of water reabsorption -- 3.1 Chapter overview -- 3.2 Blood filtration -- 3.3 The countercurrent multiplier mechanism -- 3.3.1 The Na-K-2Cl cotransporter (NKCC2) -- 3.3.2 Gradient in the inner medulla -- 3.4 The collecting duct -- 3.5 Urea transporters -- 3.6 Renal aquaporins -- 3.6.1 Aquaporin 1 -- 3.6.2 Aquaporin 2 -- 3.6.2.1 Short-term AQP2 regulation -- 3.6.2.2 Long-term AQP2 regulation -- 3.6.2.3 Regulators of AQP2 -- 3.6.3 Aquaporins 3 and 4 -- 3.6.4 Other aquaporins --4. Hyponatremia -- 4.1 Chapter overview -- 4.2 Causes and forms of hyponatremia -- 4.3 Hyponatremia and the brain -- 4.4 Hyponatremia and bone health -- 4.5 The syndrome of inappropriate antidiuretic hormone (SIADH) -- 4.5.1 Exercise-induced hyponatremia -- 4.6 Vasopressin escape and molecular mechanismS -- 4.7 Therapies/interventions --5. Diabetes insipidus -- 5.1 Chapter overview -- 5.2 Central diabetes insipidus (CDI) -- 5.3 Nephrogenic diabetes insipidus (NDI) -- 5.3.1 Mutations in the vasopressin V2 receptor -- 5.3.2 Mutations in AQP2 -- 5.4 Acquired NDI -- 5.5 Treatments for DI --6. Additional pathophysiological states associated with impaired water balance -- 6.1 Chapter overview -- 6.2 Heart failure -- 6.3 Hypertension -- 6.4 Cirrhosis of the liver -- 6.5 Compulsive water drinking -- 6.6 Burn injuries -- 6.7 Medications that alter fluid dynamics -- 6.7.1 Diuretics -- 6.7.2 Aquaretics -- 6.7.3 Peroxisome proliferator-activated receptor, subtype [gamma] (PPAR [gamma]) agonists --References -- Author biographies.This book discusses our intimate relationship with and dependence on water, how the body regulates its water levels, and various pathophysiological states associated with impairments in body water homeostasis. The human body consists of 70-80% water. Therefore, concise control of water homeostasis is essential to survival and involves coordination of several systems, but primarily the brain and kidney systems. Water requirements of the average healthy human range between 2-4 L/d, and a major portion of this can come from food sources. The major hormonal regulator of water balance is the anti-diuretic hormone, vasopressin. Vasopressin, a 9-amino acid peptide, is produced in the hypothalamus, stored in the posterior pituitary, and secreted when plasma osmolality rises. Vasopressin acts on the kidney to conserve water. The kidneys filter 180 L of blood per day, consisting of about 50-65% water, and reabsorb around 99% of this in the proximal tubule, distal tubule, and collecting duct, producing only 1-2 L of urine. The vasopressin-sensitive distal tubule and collecting duct are responsible for fine-tuning water reabsorption. Conditions exist, however, where urine cannot be concentrated effectively. This is known as diabetes insipidus and can lead to dehydration and failure to thrive. At the other extreme, hyponatremia (low serum sodium) is the inability to adequately dilute urine or get rid of free body water in excess of body needs, a serious and sometimes fatal condition.Colloquium digital library of life sciences.Colloquium series on integrated systems physiology ;# 68.2154-5626OsmoregulationWater in the bodyOsmoregulationBody Waterwater homeostasistotal body waterkidneyhydrationaquaporindiabetes insipidushyponatremiavasopressinosmolalityOsmoregulation.Water in the body.Osmoregulation.Body Water.572.3Ecelbarger Carolyn M.1264405Chaudhary Dharmendra KumarLee HwalTiwari SwastiCaBNVSLCaBNVSLCaBNVSLBOOK9910153635703321Molecular mechanisms of body water homeostasis2964335UNINA04941nam 22006735 450 991077024730332120240312132852.09783031422126303142212010.1007/978-3-031-42212-6(MiAaPQ)EBC31021849(Au-PeEL)EBL31021849(DE-He213)978-3-031-42212-6(CKB)29403468400041(OCoLC)1415807592(EXLCZ)992940346840004120231215d2024 u| 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierCyberSecurity in a DevOps Environment From Requirements to Monitoring /edited by Andrey Sadovykh, Dragos Truscan, Wissam Mallouli, Ana Rosa Cavalli, Cristina Seceleanu, Alessandra Bagnato1st ed. 2024.Cham :Springer Nature Switzerland :Imprint: Springer,2024.1 online resource (329 pages)Print version: Sadovykh, Andrey CyberSecurity in a DevOps Environment Cham : Springer,c2024 9783031422119 Part I: Security Requirements Engineering -- 1. A Taxonomy of Vulnerabilities, Attacks, and Security Solutions in Industrial PLCs -- 2. Natural Language Processing with Machine Learning for Security Requirements Analysis - Practical Approaches -- 3. Security Requirements Formalisation with RQCODE -- Part II: Prevention at Development Time -- 4. Vulnerability Detection and Response: Current Status and New Approaches -- 5. Metamorphic Testing for Verification and Fault Localization in Industrial Control Systems -- 6. Interactive Application Security Testing with Hybrid Fuzzing and Statistical Estimators -- Part III: Protection at Operations -- 7. CTAM: a tool for Continuous Threat Analysis and Management -- 8. EARLY - a tool for real-time security attack detection -- 9. A Stream-Based Approach to Intrusion Detection -- 10. Towards Anomaly Detection using Explainable AI. .This book provides an overview of software security analysis in a DevOps cycle including requirements formalisation, verification and continuous monitoring. It presents an overview of the latest techniques and tools that help engineers and developers verify the security requirements of large-scale industrial systems and explains novel methods that enable a faster feedback loop for verifying security-related activities, which rely on techniques such as automated testing, model checking, static analysis, runtime monitoring, and formal methods. The book consists of three parts, each covering a different aspect of security engineering in the DevOps context. The first part, "Security Requirements", explains how to specify and analyse security issues in a formal way. The second part, "Prevention at Development Time", offers a practical and industrial perspective on how to design, develop and verify secure applications. The third part, "Protection at Operations", eventually introducestools for continuous monitoring of security events and incidents. Overall, it covers several advanced topics related to security verification, such as optimizing security verification activities, automatically creating verifiable specifications from security requirements and vulnerabilities, and using these security specifications to verify security properties against design specifications and generate artifacts such as tests or monitors that can be used later in the DevOps process. The book aims at computer engineers in general and does not require specific knowledge. In particular, it is intended for software architects, developers, testers, security professionals, and tool providers, who want to define, build, test, and verify secure applications, Web services, and industrial systems.Software engineeringData protectionComputer programsTestingCooperating objects (Computer systems)Software EngineeringData and Information SecuritySoftware TestingCyber-Physical SystemsSoftware engineering.Data protection.Computer programsTesting.Cooperating objects (Computer systems)Software Engineering.Data and Information Security.Software Testing.Cyber-Physical Systems.005.10289Sadovykh Andrey1460300Truscan Dragos1460301Mallouli Wissam1460302Cavalli Ana Rosa867218Seceleanu Cristina1378505Bagnato Alessandra1460303MiAaPQMiAaPQMiAaPQBOOK9910770247303321CyberSecurity in a DevOps Environment3660163UNINA