05743nam 2200361 450 991076574460332120230324075737.03-03897-801-9(CKB)5400000000000212(NjHacI)995400000000000212(EXLCZ)99540000000000021220230324d2019 uy 0engur|||||||||||txtrdacontentcrdamediacrrdacarrierCarbonic anhydrases and metabolism /Claudiu T. SupuranBasel, Switzerland :MDPI,[2019]©20191 online resource (184 pages)About the Special Issue Editor vii -- Claudiu T. Supuran Carbonic Anhydrases and Metabolism Reprinted from: Metabolites 2018, 8, 25, doi:10.3390/metabo8020025 . 1 -- Claudiu T. Supuran Carbonic Anhydrase Inhibition and the Management of Hypoxic Tumors Reprinted from: Metabolites 2017, 7, 48, doi:10.3390/metabo7030048 . 6 -- Paul C. McDonald, Mridula Swayampakula and Shoukat Dedhar Coordinated Regulation of Metabolic Transporters and Migration/Invasion by Carbonic Anhydrase IX Reprinted from: Metabolites 2018, 8, 20, doi:10.3390/metabo8010020 . 19 -- Mam Y. Mboge, Brian P. Mahon, Robert McKenna and Susan C. Frost Carbonic Anhydrases: Role in pH Control and Cancer Reprinted from: Metabolites 2018, 8, 19, doi:10.3390/metabo8010019 . 30 -- Carol Ward, James Meehan, Mark Gray, Ian H. Kunkler, Simon P. Langdon and David J. Argyle Carbonic Anhydrase IX (CAIX), Cancer, and Radiation Responsiveness Reprinted from: Metabolites 2018, 8, 13, doi:10.3390/metabo8010013 . 61 -- Elisabetta Iessi, Mariantonia Logozzi, Davide Mizzoni, Rossella Di Raimo, Claudiu T. Supuran and Stefano Fais Rethinking the Combination of Proton Exchanger Inhibitors in Cancer Therapy Reprinted from: Metabolites 2018, 8, 2, doi:10.3390/metabo8010002 79 -- Niccol `o Chiaramonte, Maria Novella Romanelli, Elisabetta Teodori and Claudiu T. Supuran Amino Acids as Building Blocks for Carbonic Anhydrase Inhibitors Reprinted from: Metabolites 2018, 8, 36, doi:10.3390/metabo8020036 . 99 -- Morteza Abdoli, Murat Bozdag, Andrea Angeli and Claudiu T. Supuran Benzamide-4-Sulfonamides Are Effective Human Carbonic Anhydrase I, II, VII, and IX Inhibitors Reprinted from: Metabolites 2018, 8, 37, doi:10.3390/metabo8020037 . 121 -- Ashok Aspatwar, Susanna Haapanen and Seppo Parkkila An Update on the Metabolic Roles of Carbonic Anhydrases in the Model Alga Chlamydomonas reinhardtii Reprinted from: Metabolites 2018, 8, 22, doi:10.3390/metabo8010022 . 132 -- Silvia Bua, Susanna Haapanen, Marianne Kuuslahti, Seppo Parkkila and Claudiu T. Supuran Activation Studies of the β-Carbonic Anhydrase from the Pathogenic Protozoan Entamoeba histolytica with Amino Acids and Amines Reprinted from: Metabolites 2019, 9, 26, doi:10.3390/metabo9020026 . 148 -- Claudiu T. Supuran and Clemente Capasso An Overview of the Bacterial Carbonic Anhydrases Reprinted from: Metabolites 2017, 7, 56, doi:10.3390/metabo7040056 . 156.Carbonic anhydrases (CAs; EC 4.2.1.1) are metalloenzymes present in all kingdoms of life, as they equilibrate the reaction between three simple but essential chemical species: CO2, bicarbonate, and protons. Discovered more than 80 years ago, in 1933, these enzymes have been extensively investigated due to the biomedical application of their inhibitors, but also because they are an extraordinary example of convergent evolution, with seven genetically distinct CA families that evolved independently in Bacteria, Archaea, and Eukarya. CAs are also among the most efficient enzymes known in nature, due to the fact that the uncatalyzed hydration of CO2 is a very slow process and the physiological demands for its conversion to ionic, soluble species is very high. Inhibition of the CAs has pharmacological applications in many fields, such as antiglaucoma, anticonvulsant, antiobesity, and anticancer agents/diagnostic tools, but is also emerging for designing anti-infectives, i.e., antifungal, antibacterial, and antiprotozoan agents with a novel mechanism of action. Mitochondrial CAs are implicated in de novo lipogenesis, and thus selective inhibitors of such enzymes may be useful for the development of new antiobesity drugs. As tumor metabolism is diverse compared to that of normal cells, ultimately, relevant contributions on the role of the tumor-associated isoforms CA IX and XII in these phenomena have been published and the two isoforms have been validated as novel antitumor/antimetastatic drug targets, with antibodies and small-molecule inhibitors in various stages of clinical development. CAs also play a crucial role in other metabolic processes connected with urea biosynthesis, gluconeogenesis, and so on, since many carboxylation reactions catalyzed by acetyl-coenzyme A carboxylase or pyruvate carboxylase use bicarbonate, not CO2, as a substrate. In organisms other than mammals, e.g., plants, algae, and cyanobacteria, CAs are involved in photosynthesis, whereas in many parasites (fungi, protozoa), they are involved in the de novo synthesis of important metabolites (lipids, nucleic acids, etc.). The metabolic effects related to interference with CA activity, however, have been scarcely investigated. The present Special Issue of Metabolites aims to fill this gap by presenting the latest developments in the field of CAs and their role in metabolism.MetalloenzymesMetalloenzymes.572.51Supuran Claudiu T.1344282NjHacINjHaclBOOK9910765744603321Carbonic anhydrases and metabolism3652651UNINA05203nam 22006971 450 991078426400332120020822171602.01-4725-6212-71-280-80117-497866108011761-84731-232-210.5040/9781472562128(CKB)1000000000338571(EBL)285388(OCoLC)476036622(SSID)ssj0000148830(PQKBManifestationID)11147023(PQKBTitleCode)TC0000148830(PQKBWorkID)10235968(PQKB)11644913(MiAaPQ)EBC1750738(MiAaPQ)EBC285388(Au-PeEL)EBL1750738(CaPaEBR)ebr10276224(CaONFJC)MIL80117(OCoLC)893331420(OCoLC)1112520177(UtOrBLW)bpp09256478(Au-PeEL)EBL285388(EXLCZ)99100000000033857120140929d2000 uy 0engur|n|---|||||txtccrEquality a new framework : report of the independent review of the enforcement of UK anti-discrimination legislation /Bob Hepple, Mary Coussey, Tufyal Choudhury1st ed.Oxford ;Portland, Oregon :Hart Publishing,2000.1 online resource (172 p.)"The University of Cambridge Centre for Public Law and Judge Institute of Management Studies."1-84113-159-8 Includes bibliographical references (pages [143]-145).Introduction - Aims and Methodology -- Ch. 1 - Why a new famework is needed -- Ch. 2 - Harmonising legislation and institutions -- Ch. 3 - Changing organisational policy and behaviour -- Ch. 4 - Making procedures and remedies more effective -- Appendices."The need for a legislative framework for ensuring equality of opportunity is not seriously questioned in the UK. However,despite the presence on the Statute book of various significant pieces legislation dating back to the mid 1970s, there remain deep-seated structural disadvantages which blight the lives of many women, Black and Asian people, and disabled persons. The Stephen Lawrence inquiry report highlighted the presence of institutionalised racism in the police. Similar barriers can also be found in other public services and in private sector organisations. There are also insistent demands for the extension of legislation to cover discrimination on other grounds such as religion, age and sexual orientation. Discriminatory behaviour cannot be remedied by legislation alone, or simply by the actions of government, courts and tribunals and Commissions. Political and social leadership, customer and peer pressure, the development of good practices and campaigning all have a crucial part to play. Employers, trade unions, social organisations and clubs, service providers and individuals all have to take voluntary action to achieve the goals of the legislation. One thing that is clear is that the present legislation is badly in need of modernisation. The present acts are outdated, piecemeal and inconsistent. They fall short of the standards set by EU law, international human rights law, and the Human Rights Act. In writing this report, the authors set out to develop an accessible and cost-effective legislative framework for ensuring equality of opportunity, and to propose other measures which will promote equal opportunity policies and spur compliance with those policies. In the course of preparing the report they have considered experience in other countries. They have heard from many individuals and organisations who have either experienced the effects of discrimination or attempted to counter it. They conducted a survey of employers in Britain, Northern Ireland and the USA, which shows that human resource managers are looking for a new more inclusive approach not only to prevent discrimination but also to provide positively for the fair participation of all groups. These views, together with those of an advisory group drawn from government, the Commissions, and tribunals, as well as a panel of academic and practising lawyers, form the backdrop to the recommendations contained in this report. Coming at a time when the Government is committed to introducing new equality legislation the report is bound to be highly influential. It will be essential reading for all those interested in human rights, discrimination and employment law, and human resources management."--Bloomsbury Publishing.DiscriminationLaw and legislationGreat BritainEmployment & labour lawDiscriminationLaw and legislation344.4101133929.20973Hepple B. A.1496595Choudhury TufyalCoussey MaryJudge Institute of Management Studies.University of Cambridge.Centre for Public Law.UtOrBLWUtOrBLWBOOK9910784264003321Equality3721379UNINA01619nas 22005293a 450 991014499130332120241223110440.01941-5885(OCoLC)212412174(CKB)1000000000391574(CONSER)--2008213436(MiFhGG)2KXZ(EXLCZ)99100000000039157420080229b20072015 s-- aengur|||||||||||txtrdacontentcrdamediacrrdacarrierBriefings on the Joint CommissionMarblehead, MA HCPro1 online resource1941-5877 BOJHospitalsAccreditationPeriodicalsMedical careQuality controlPeriodicalsAccreditationstandardsQuality of Health CareHospitalsAccreditationfast(OCoLC)fst00961174Medical careQuality controlfast(OCoLC)fst01013833HealthgalestnePeriodicals.fastNWL (Newsletter)galestneHospitalsAccreditationMedical careQuality controlAccreditationstandards.Quality of Health Care.HospitalsAccreditation.Medical careQuality control.Health.610HCPro (Firm)Joint Commission (Oakbrook Terrace, Ill.)JOURNAL9910144991303321Briefings on the Joint Commission2565463UNINA