01105nam0 22003133i 450 CAG005071820170908093242.020170627d1980 ||||0itac50 baitaitz01i xxxe z01nAnni verdiA. J. Cronin2. edMilanoBompiani1980426 p.19 cmTascabili Bompiani. Opere di Cronin7In cop.: La dolce memoria di Cronin001RAV01247162001 Tascabili Bompiani. Opere di Cronin7Cronin, Archibald JosephCFIV001061070167681Vismara, SpinaSBLV079582730Cronin, A. J.SBNV006546Cronin, Archibald JosephITIT-NA007920170627IT-SA0252CAG0050718Biblioteca del Centro Documentazione per le Politiche del Lavoro 83AME 7 E 13 83 0000021025 B 1 v.C 2017062720170627 83Anni verdi290418UNISANNIO04668nam 22007695 450 991075408990332120260209150440.09783031387319(electronic bk.)978303138730210.1007/978-3-031-38731-9(MiAaPQ)EBC30795564(Au-PeEL)EBL30795564(DE-He213)978-3-031-38731-9(PPN)272919799(CKB)28527607200041(EXLCZ)992852760720004120231018d2023 u| 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierCPP, Cell-Penetrating Peptides /by Ülo Langel2nd ed. 2023.Cham :Springer International Publishing :Imprint: Springer,2023.1 online resource (564 pages)Print version: Langel, Ülo CPP, Cell-Penetrating Peptides Cham : Springer International Publishing AG,c2023 9783031387302 1. Introduction -- 2. Classes and applications of CPP -- 3. CPP selection, prediction and in silico analysis -- 4. Labeling of CPPs -- 5. Methods for CPP functionalization with oligonucleotides -- 6. Additional (gene therapeutic) platforms -- 7. Protein delivery and mimicry -- 8. General targeting strategies -- 9. Targeting specific barriers -- 10. Methods for molecular imaging, detection and visualization of CPPs -- 11. Methods for structural studies of CPPs -- 12. Kinetics -- 13. Toxicity and immune response -- 14. Cell-translocation mechanisms of CPPs -- 15. Clinical trials and commercialization using CPPs -- 16. Therapeutic potential of CPPs -- 17. CPP functionalized nanoparticles -- 18. Concluding remarks.In this book, a summary and update of the most important areas of cell-penetrating peptides (CPP) research are presented, while raising relevant questions for further development. The CPP sequences are presented and discussed throughout the book. The methods for testing CPP mechanisms are discussed in detail. Various approaches for the testing of endocytotic pathways of CPP uptake are also described. Different CPP uptake experiments are compared since it is becoming clear that it is often best to apply several methods in a complementary manner in order to most comprehensively evaluate CPP uptake mechanisms due to the complexity of these processes. A brief summary of functionality issues of CPPs, both in vitro and in vivo, is discussed. Therapeutic potential of CPPs and commercial developments are discussed. The present, second edition of this book is the updated and expanded version of the first edition, published in 2019. The development of the field of cell-penetrating peptides in these five years has been obvious and exciting. This second edition of the book has been partly reorganized and comprehensively expanded with the exciting research in 2019-2023. Around 2500 novel scientific articles have become available, most of them are reviewed in the second edition. Additional rapidly growing areas of high impact presented in this second edition are therapeutic developments (Chapter 16) and delivery of oligonucleotides and proteins/peptides (Chapters 5 and 6) including novel reports on genome editing with CPP assistance. Also, several additional examples are available now on clinical trials using CPPs (Chapter 15). The book is written for researchers and students in the field.Drug delivery systemsProteinsPharmacologyProteinsPharmaceutical chemistryBiomaterialsDrug DeliveryProteinsPharmacologyProtein BiochemistryMedicinal ChemistryBiomaterials-ProteinsProteòmicathubMedicaments peptídicsthubLlibres electrònicsthubDrug delivery systems.Proteins.Pharmacology.Proteins.Pharmaceutical chemistry.Biomaterials.Drug Delivery.Proteins.Pharmacology.Protein Biochemistry.Medicinal Chemistry.Biomaterials-Proteins.ProteòmicaMedicaments peptídics572.65572.65Langel Ülo0MiAaPQMiAaPQMiAaPQ9910754089903321CPP, Cell-Penetrating Peptides2140606UNINA