03600nam 22007215 450 991074118310332120200702144744.03-319-00303-810.1007/978-3-319-00303-0(CKB)2670000000371233(EBL)1317006(SSID)ssj0000894401(PQKBManifestationID)11436495(PQKBTitleCode)TC0000894401(PQKBWorkID)10835244(PQKB)10385878(DE-He213)978-3-319-00303-0(MiAaPQ)EBC1317006(PPN)170489531(EXLCZ)99267000000037123320130518d2013 u| 0engur|n|---|||||txtccrIron Acquisition by the Genus Mycobacterium History, Mechanisms, Role of Siderocalin, Anti-Tuberculosis Drug Development /edited by B. Rowe Byers1st ed. 2013.Cham :Springer International Publishing :Imprint: Springer,2013.1 online resource (96 p.)SpringerBriefs in Biometals,2212-9901Description based upon print version of record.3-319-00302-X Includes bibliographical references and index.A History of Iron Metabolism in the Mycobacteria -- Mycobacterial Iron Uptake Mechanisms -- Siderocalin Combats Mycobacterial Infections -- Design of Anti-TB Drugs Using the Iron Uptake Platform.Iron Acquisition by the Genus Mycobacterium summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is described.  The genes so far identified as essential for iron acquisition and maintenance of an infection by pathogenic mycobacteria are discussed.  The potential role of siderocalin in iron gathering by M. tuberculosis is featured. Because new drugs for M. tuberculosis are needed, this brief also emphasizes the design of antibiotics that interfere with siderophore biosynthesis and the use of siderophore analogs and/or conjugates.SpringerBriefs in Biometals,2212-9901MicrobiologyProteins Inorganic chemistryBioorganic chemistryInfectious diseasesMicrobiologyhttps://scigraph.springernature.com/ontologies/product-market-codes/L23004Protein-Ligand Interactionshttps://scigraph.springernature.com/ontologies/product-market-codes/L14060Inorganic Chemistryhttps://scigraph.springernature.com/ontologies/product-market-codes/C16008Bioorganic Chemistryhttps://scigraph.springernature.com/ontologies/product-market-codes/C19010Infectious Diseaseshttps://scigraph.springernature.com/ontologies/product-market-codes/H33096Microbiology.Proteins .Inorganic chemistry.Bioorganic chemistry.Infectious diseases.Microbiology.Protein-Ligand Interactions.Inorganic Chemistry.Bioorganic Chemistry.Infectious Diseases.572.517Byers B. Roweedthttp://id.loc.gov/vocabulary/relators/edtBOOK9910741183103321Iron Acquisition by the Genus Mycobacterium3554193UNINA