03859nam 2200613Ia 450 991073944260332120200520144314.01-4614-7678-X10.1007/978-1-4614-7678-8(CKB)2670000000530496(EBL)1398462(OCoLC)858763537(SSID)ssj0000988060(PQKBManifestationID)11534662(PQKBTitleCode)TC0000988060(PQKBWorkID)10950642(PQKB)11478430(DE-He213)978-1-4614-7678-8(MiAaPQ)EBC1398462(PPN)172419700(EXLCZ)99267000000053049620111102d2013 uy 0engur|n|---|||||txtccrBiophysics of the failing heart physics and biology of heart muscle /R. John Solaro, Jil C. Tardiff, editors1st ed. 2013.New York Springer Science20131 online resource (254 p.)Biological and medical physics, biomedical engineeringDescription based upon print version of record.1-4614-7677-1 1-4939-0185-0 Includes bibliographical references and index.Chapter 1 Introduction to the Biophysics of the Failing Heart -- Chapter 2 Sarcoplasmic reticulum Ca homeostasis and Heart Failure -- Chapter 3 Ca-homeostasis and Heart Failure: Focus on the Biophysics of Surface Membrane Ca-Fluxes -- Chapter 4 Biophysics of Membrane Currents in Heart Failure -- Chapter 5 Biophysical Mechanisms for the Metabolic Component of Impaired Heart Function -- Chapter 6 Cytoskeletal Nuclear Links in the Cardiomyocyte -- Chapter 7 Biophysical Forces Modulate the Costamere and Z-Disc -- Chapter 8 Heart failure- the final frontier for biophysics in cardiovascular medicine? -- Chapter 9 Arrhythmogenesis, Heart Failure, and the Biophysics of Z-band Protein Networks -- Chapter 10 Biophysics of Titin in Cardiac Health and Disease -- Chapter 11 Sarcomeres and the Biophysics of Heart Failure -- Index.Biophysics of the Failing Heart considers major biophysical mechanisms for why hearts responding to stressors enter into maladaptive processes, eventually leading to an inability of the heart to respond efficiently to hemodynamic loads--especially during exercise. The book describes biophysical techniques that have been applied to determine the triggers for the heart failure process, as well as the mechanisms for sustaining the disorders. These techniques include measurements of active and passive mechanical properties and hemodynamics at levels of organization ranging from molecules to hearts beating in situ. Biophysical concepts and approaches are also applied to determination of signaling and signal transduction, energetics, ionic currents, transport processes, electro-chemical and chemo-mechanical coupling. Modern research approaches and clinical understanding of heart failure demands integration of multiple aspects of the disorders. By its emphasis on biophysical aspects of a prevalent clinical condition, this monograph is unique in its perspective and focus, and will be of value to clinicians and researchers at all levels.Biological and Medical Physics, Biomedical Engineering,1618-7210Heart failurePathophysiologyHeartPhysiologyHeart failurePathophysiology.HeartPhysiology.616.12616/.014Solaro R. John1755093Tardiff Jill C1755094MiAaPQMiAaPQMiAaPQBOOK9910739442603321Biophysics of the failing heart4191721UNINA