03232nam 2200565Ia 450 991073943080332120200520144314.01-4614-6549-410.1007/978-1-4614-6549-2(CKB)2550000001043799(EBL)1205332(SSID)ssj0000880113(PQKBManifestationID)11454621(PQKBTitleCode)TC0000880113(PQKBWorkID)10872928(PQKB)11718481(DE-He213)978-1-4614-6549-2(MiAaPQ)EBC1205332(PPN)169136388(EXLCZ)99255000000104379920130423d2013 uy 0engur|n|---|||||txtccrMolecular genetics of pancreatic cancer /Diane M. Simeone, Anirban Maitra, editors1st ed. 2013.New York Springerc20131 online resource (235 p.)"Laboratory medicine."1-4899-9435-1 1-4614-6548-6 Includes bibliographical references and index.Genomic Alterations in Sporadic Pancreatic Cancer -- Molecular Pathology of Pancreatic Cancer Precursor Lesions -- Genetic Epidemiology and Pancreatic Cancer -- Translational Implications of Molecular genetics for Early Diagnosis of Pancreatic Cancer -- The Biology of K-Ras Signaling Pathways in Pancreatic Cancer -- Molecularly Targeted Therapies in Pancreatic Cancer -- Mouse Models of Pancreatic Cancer -- Genetics of Pancreatic Cancer Metastasis -- Epigenetic Alterations in Pancreatic Cancer -- New technologies in Molecular Characterization of Pancreatic Cancer -- Index.Pancreatic cancer is a formidable disease, and advances in early detection and improved therapeutics have been slow to come forth. With new advances in molecular genetics in the field of pancreatic tumorigenesis, it is an opportune time to use these recent discoveries to enhance our understanding of pancreatic cancer biology and to improve outcomes in patients.  In this volume, leading experts in the field shed light on these findings describing the mutational landscape of pancreatic cancer, including new inroads into our understanding of familial pancreatic cancer, epidemiology, the biology of K-ras signaling, and the emerging contribution of epigenetic alterations to disease initiation and progression. The distinctive pancreatic cancer-stroma ecosystem as determined by the dynamic interplay of inflammation, hallmark mutations, EMT, and cancer stem cells is described, and implications of these interactions in the context of development of novel, personalized therapeutic options are explored.PancreasCancerMolecular aspectsCancerGenetic aspectsPancreasCancerMolecular aspects.CancerGenetic aspects.616.99437Simeone Diane M1755090Maitra Anirban1755091MiAaPQMiAaPQMiAaPQBOOK9910739430803321Molecular genetics of pancreatic cancer4191719UNINA