02822nam 2200493 a 450 991073940590332120200520144314.03-642-37999-010.1007/978-3-642-37999-4(OCoLC)852664400(MiFhGG)GVRL6VBN(CKB)2670000000403422(MiAaPQ)EBC1317689(EXLCZ)99267000000040342220130605d2013 uy 0engurun|---uuuuatxtccrDisruption of protein-protein interfaces in search of new inhibitors /Stefano Mangani, editor1st ed. 2013.New York Springer20131 online resource (vii, 161 pages) illustrations (some color)Gale eBooksDescription based upon print version of record.3-642-43389-8 3-642-37998-2 Includes bibliographical references and index.Drug discovery by targeting protein-protein interactions -- Protein-Protein Interaction Inhibitors: case studies on small molecules and natural compounds -- Disrupting Protein-Protein Interfaces using GRID Molecular Interaction Fields -- NMR as a tool to target protein-protein interactions -- Protein-protein interactions in the solid state The troubles of crystallizing of protein- protein complexes -- Fluorescence observables and enzyme kinetics in the investigation of PPI modulation by small molecules Detection, mechanistic insight, functional consequences."Disruption of Protein-Protein Interfaces" reviews the latest developments and future perspectives in drug discovery at protein-protein interfaces, as well as including details of experimental and computational tools to tackle the subject, and highlighting the contribution of the Italian research community to the field. Evidence shows that blocking or modulating protein-protein interactions might lead to the development of useful new drugs. Consequently, in recent years great effort has been dedicated to unveiling the molecular details of protein-protein interfaces by structural techniques e.g. X-ray diffraction, NMR spectroscopy. This book, written and edited by leaders in the field, provides examples from the literature of successes and failures to develop drug-like molecules effective in interacting at protein-protein interfaces.Protein-protein interactionsProtein-protein interactions.54547547.7Mangani Stefano498471MiAaPQMiAaPQMiAaPQBOOK9910739405903321Disruption of protein-protein interfaces4187487UNINA