01143nam0 22002891i 450 UON0023287320231205103510.71420030730d1978 |0itac50 baitaIT|||| |||||ˆI ‰ Giacobiniantologia degli scritti di Marat, Robespierre e Saint-Justintrod., scelta e trad. di Ida Cappiello1. edFirenzeLa Nuova Italia1978LXV, 112 p.20 cm.001UON001768832001 Pensatori antichi e moderni210 FirenzeLa Nuova Italia106GIACOBINIUONC051647FIITFirenzeUONL000052194Filosofia occidentale moderna. Francia21CAPPIELLOIdaUONV141131La Nuova ItaliaUONV245954650ITSOL20240220RICASIBA - SISTEMA BIBLIOTECARIO DI ATENEOUONSIUON00232873SIBA - SISTEMA BIBLIOTECARIO DI ATENEOSI FS 03496 SI FP 703 5 Giacobini97907UNIOR05278nam 2200565 a 450 991073729890332120250701235257.094-007-6889-310.1007/978-94-007-6889-5(CKB)2670000000403988(EBL)1317761(OCoLC)852839815(SSID)ssj0000958067(PQKBManifestationID)11531622(PQKBTitleCode)TC0000958067(PQKBWorkID)10985039(PQKB)11604898(DE-He213)978-94-007-6889-5(MiAaPQ)EBC1317761(PPN)172433673(EXLCZ)99267000000040398820130620d2013 uy 0engur|n|---|||||txtccrPeroxisomes and their key role in cellular signaling and metabolism /Luis A. del Rio, editor1st ed. 2013.New York Springer20131 online resource (352 p.)Sub-cellular biochemistry,0306-0225 ;v. 69Description based upon print version of record.94-017-8290-3 94-007-6888-5 Includes bibliographical references and index.Peroxisome interactions and cross-talk with other subcellular compartments in animal cells -- Peroxisomes in human health and disease: metabolic pathways, metabolite transport, interplay with other organelles and signal transduction -- Aging, age-related diseases and peroxisomes -- Peroxisomes and the antiviral responses of mammalian cells -- Peroxisome proliferator-activated receptor-α signaling in hepatocarcinogenesis -- Involvement of human peroxisomes in biosynthesis and signaling of steroid and peptide hormones -- Peroxisome Ca2+ homeostasis in animal and plant cells -- The versatility of peroxisome function in filamentous fungi -- Essential roles of peroxisomally produced and metabolized biomolecules in regulating yeast longevity -- Metabolite transporters of the plant peroxisomal membrane - known and unknown -- Peroxisomes and photomorphogenesis -- Biosynthesis of vitamin K1 (phylloquinone) by plant peroxisomes and its integration into signaling molecule synthesis pathways -- Role of peroxisomes as a source of reactive oxygen species (ROS) signaling molecules -- Peroxisomes as a source of auxin signaling molecules -- Peroxisomes as cell generators of reactive nitrogen species (RNS) signal molecules -- Role of plant peroxisomes in the production of jasmonic acid-based signals -- Role of plant peroxisomes in protection against herbivores -- Function of Peroxisomes in Plant-Pathogen Interactions.Peroxisomes are a class of ubiquitous and dynamic single membrane-bounded cell organelles, devoid of DNA, with an essentially oxidative type of metabolism. Today it is known that fatty acid β-oxidation is a general feature of virtually all types of peroxisomes, but in higher eukaryotes, including humans, peroxisomes catalyze ether phospholipids biosynthesis, fatty acid α-oxidation, and glyoxylate detoxification, and in humans peroxisomes are associated with several important genetic diseases. Among the different new roles for human peroxisomes discovered in recent years are antiviral innate immunity, peptide hormone metabolism, brain aging and Alzheimer’s disease, and age-related diseases. In fungi, new findings have broadened the number of secondary metabolites that are synthesized in peroxisomes, such as antibiotics and several toxins, and have evidenced their involvement in biotin biosynthesis, fungal development and plant pathogenesis. In plants, peroxisomes carry out different functions, apart from fatty acid β-oxidation, mainly including photorespiration, metabolism of reactive oxygen, nitrogen and sulfur species, photomorphogenesis, biosynthesis of phytohormones, senescence, and defense against pathogens and hervibores. Two important characteristics of peroxisomes are their metabolic plasticity and capacity of sharing metabolic pathways with other cell compartments. In recent years, a function for peroxisomes as key centers of the cellular-signaling apparatus which could influence the regulatory network of the cell has been postulated. The diverse key physiological functions that have been demonstrated for peroxisomes from different origins strongly indicate the interest of studying the role of peroxisomes as a cellular source of different signaling molecules. This book presents recent advances in the function and metabolism of peroxisomes from human, animal, fungal and plant origin and their metabolic interconnection with other cell compartments, showing the central role played by peroxisomes as cell generators of different signaling molecules involved in distinct processes of high physiological importance.Sub-cellular biochemistry,2542-8810 ;v. 69.PeroxisomesPeroxisomes.571.655Rio Luis A. del1752238MiAaPQMiAaPQMiAaPQBOOK9910737298903321Peroxisomes and their key role in cellular signaling and metabolism4187498UNINA