04724nam 22007575 450 991073577570332120251008131253.03-031-32554-010.1007/978-3-031-32554-0(MiAaPQ)EBC30656997(Au-PeEL)EBL30656997(DE-He213)978-3-031-32554-0(PPN)272250503(CKB)27675012200041(EXLCZ)992767501220004120230719d2023 u| 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierAdvances in Maternal-Fetal Biomedicine Cellular and Molecular Mechanisms of Pregnancy Pathologies /edited by Marcelo Gonzalez-Ortiz1st ed. 2023.Cham :Springer International Publishing :Imprint: Springer,2023.1 online resource (314 pages)Advances in Experimental Medicine and Biology,2214-8019 ;1428Print version: Gonzalez-Ortiz, Marcelo Advances in Maternal-Fetal Biomedicine Cham : Springer International Publishing AG,c2023 9783031325533 Includes bibliographical references and index.Feto-Placental Unit: from development to function -- Role of hormones during gestation and early development: pathways involved in developmental programming -- Physiological and pathophysiological role of large-conductance calcium-activated potassium channels (BKCa) in HUVECs and placenta -- Metabolic interaction between Folate, Vitamin B12 and Polyunsaturated Fatty Acids in pregnancy -- Evidence of nitric oxide impairment during hypertensive pregnancies -- Pathophysiology of preeclampsia and L-Arginine/L-citrulline supplementation as a potential strategy to improve birth outcomes -- Maternal and fetal expression of ATP-binding cassette and Solute Carrier transporters involved in the brain disposition of drugs -- Development of the placenta and brain are affected by selective serotonin reuptake inhibitors exposure during critical periods -- The endocannabinoid system in placenta and respiratory central nervous system development: effects of prenatal exposure to cannabinoids -- Impact of prenatal nicotine exposure on placental function and respiratory neural network development -- Language impairment in children of mothers with gestational diabetes, preeclampsia, and preterm delivery: current hypothesis and potential underlying mechanisms -- COVID-19 on pregnancy outcomes, mental health and placenta: focus in Latin America -- The placental function beyond pregnancy: Insights from Latin America.This textbook aims to describe physiological and pathophysiological mechanisms that underlie human maternal-fetal interactions. The book emphasizes the structure and development of the fetoplacental unit, the endocrine and nutritional regulation of fetal development, nitric oxide signalling, solute carriers function and ion channels regulation in healthy pregnancies and diseases, like preeclampsia, gestational diabetes, and maternal obesity, among others. Also, we highlight novel mechanisms associated with language impairment in children, the use of serotonin inhibitors or cannabis during pregnancy, and maternal conditions' potential impact on cerebrovascular development in newborns and infants. The cellular and molecular understanding of maternal-fetal physiology and pathophysiology will allow the readers to understand the impact of diseases or conditions that are highly prevalent in pregnant women.Advances in Experimental Medicine and Biology,2214-8019 ;1428Human physiologyReproductive healthReproductionPhysiologyPharmacologyCytologyGynecologyHuman PhysiologyReproductive MedicineReproductive PhysiologyPharmacologyCell BiologyGynecologyHuman physiology.Reproductive health.Reproduction.Physiology.Pharmacology.Cytology.Gynecology.Human Physiology.Reproductive Medicine.Reproductive Physiology.Pharmacology.Cell Biology.Gynecology.618.2González-Ortiz MarceloMiAaPQMiAaPQMiAaPQBOOK9910735775703321Advances in Maternal-Fetal Biomedicine3417120UNINA