03651nam 2200637 450 991013753370332120230621141321.09782889195565 (ebook)(CKB)3710000000569661(SSID)ssj0001695634(PQKBManifestationID)16546698(PQKBTitleCode)TC0001695634(PQKBWorkID)15066458(PQKB)25091943(WaSeSS)IndRDA00058398(oapen)https://directory.doabooks.org/handle/20.500.12854/48349(EXLCZ)99371000000056966120160829d2015 uy |engur|||||||||||txtccrGene function in schistosomes recent advances towards a cure /edited by: Arnon Dias Jurberg and Paul J. BrindleyFrontiers Media SA2015Switzerland :Frontiers Media SA,20151 online resource (154 pages) illustrationsFrontiers Research TopicsBibliographic Level Mode of Issuance: MonographIncludes bibliographical references.Includes bibliographical references.Schistosomes are human parasites distributed worldwide in tropical and sub-tropical latitudes, especially in developing countries and impoverished regions. These neglected tropical disease (NTD) pathogens causes debilitating illnesses, which include hepatosplenomegaly, hepatic fibrosis, haemorrhagic necrotic ulcerations in the intestinal mucosa, urogenital tract diseases, in addition to cardiopulmonary, renal and neurologic lesions due to egg accumulation in the liver, intestines, uro-genital tissues and other sites. Urogenital schistosomiasis is a risk factor for bladder cancer and increases the risk of transmission of HIV infection.Despite extensive effort to control this NTD over the years, deployment on a considerable scale of commercially available drugs in endemic populations has induced the emergence of resistant isolates and raised the need to identify new targets for alternative therapies. Because of the availability of genomes of the three major species of human schistosomiasis, and through advances in functional genomics and live imaging, studies on schistosomes have now come into focus as models to investigate adaptations to parasitism and developmental biology of trematodes and cestodes, and indeed flatworms and Lophotrochozoans, at large.This Research Topic aims at gathering state-of-art essays on schistosome genetics, genetics, pathobiology and immunobiology. It also aims to highlight advances in understanding of the host-parasite relationship, in paradigms that address this NTD, and to discuss new perspectives and advances in chemotherapy and immunoprophylaxis.Communicable DiseasesHILCCPublic HealthHILCCHealth & Biological SciencesHILCCSchistosomiasisSchistosoma mansoniS japonicumneglected tropical diseasesinfection induced cancerAnthelmintic drugsS haematobiumBlood flukeVaccinesHelminthiasisCommunicable DiseasesPublic HealthHealth & Biological SciencesArnon Dias Jurbergauth1367192Jurberg Arnon DiasBrindley Paul JPQKBUkMaJRU9910137533703321Gene function in schistosomes3389922UNINA04176nam 22006495 450 991073147060332120251008163627.09783031271601303127160210.1007/978-3-031-27160-1(MiAaPQ)EBC30601975(Au-PeEL)EBL30601975(DE-He213)978-3-031-27160-1(CKB)27060358000041(OCoLC)1392347336(EXLCZ)992706035800004120230615d2023 u| 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierArt Discovery and Censorship in the Centre William Rappard of Geneva Building the Future /by Edmundo Murray1st ed. 2023.Cham :Springer International Publishing :Imprint: Palgrave Macmillan,2023.1 online resource (227 pages)Print version: Murray, Edmundo Art Discovery and Censorship in the Centre William Rappard of Geneva Cham : Springer International Publishing AG,c2023 9783031271595 1. The Art Paradox: Between Love and Fear of the Image -- 2. 1926 – Metaphors of Hope -- 3. 1930 – “Sex and drunkenness and, yes, sin”: The Geneva Window that never arrived in Geneva -- 4. 1937 – “He wishes that it be removed”: Hiding Pygmalion -- 5. 1977 – “Profane, almost sentimentalist, almost human”: The GATT Secretariat in the Centre William Rappard -- 6. 2013 – Fresh Air: Rediscovering and Restoring Artworks -- 7. 2020 – The end of humour -- 8. Ars celare artem.This is a history of the Centre William Rappard, the first building designed to house an international organization in Geneva, and its art treasures. For nearly a century, these works of art and decorations offered by governments and institutions encouraged smooth diplomacy and fluent international negotiations in the fields of labour, trade and human rights. On occasions hidden, removed and forgotten, and then recovered and restored, the history of the artworks in the Centre William Rappard represents the confrontation between art as diplomatic device and aesthetic experience, between representation and represented, between censorship and free expression. Even before its opening in 1926, the building started receiving works from the International Labour Organization member governments. Some pieces, such as the Geneva Window by Harry Clarke, never arrived in Geneva since it was censored by the Irish government. The Spanish Pygmalion by Eduardo Chicharro y Agüera was latter covered for its female nudity and remained hidden during decades. Later in the 1970s the secretariat of the General Agreement on Tariffs and Trade occupied the building and requested the removal of other major works. This was reversed in the 2010s by its successor the World Trade Organization, when many artworks were rediscovered, restored and placed in their original locations. However, new values in the world scene contributed to further changes in the building art, including the removal of Claude Namy’s caricature In GATT We Trust from public view in 2019. Art in the Centre William Rappard continues to speak to the viewer after waves of positive reception, censorship and recovery. .ArtHistoryArchitectureEthnologyEuropeCultureCities and townsHistoryArt HistoryArchitectureEuropean CultureUrban HistoryArtHistory.Architecture.EthnologyCulture.Cities and townsHistory.Art History.Architecture.European Culture.Urban History.709701.03Murray Edmundo1369208MiAaPQMiAaPQMiAaPQBOOK9910731470603321Art Discovery and Censorship in the Centre William Rappard of Geneva3395265UNINA