02009nam 2200397 450 991071977250332120230629191520.03-0365-7184-1(CKB)4960000000467881(NjHacI)994960000000467881(EXLCZ)99496000000046788120230629d2023 uy 0engur|||||||||||txtrdacontentcrdamediacrrdacarrierGenetic and Epigenetic Regulations of Tumor Progression and Metastasis /Bozena Smolkova, Julie Earl, Agapi Kataki, editors[Place of publication not identified] :MDPI - Multidisciplinary Digital Publishing Institute,2023.1 online resource (208 pages)3-0365-7185-X Genetic aberrations and epigenetic modifications are critical drivers of cancer progression and metastasis. Although recurrent mutations in primary and metastatic cancers have been shown to be concordant, there are several metastasis-associated mutations responsible for resistance to specific therapies that are frequently located in genes that regulate DNA methylation and chromatin modifications. Recent studies have shown that distinct subgroups of poor-prognosis tumors lack genetic alterations but are epigenetically regulated, pointing to the critical role of epigenetic modifications in cancer progression. This Special Issue provides novel insights into the mechanisms underlying processes associated with cancer cell plasticity and the development of metastatic disease.ChemotherapyTumorsChemotherapy.Tumors.616.994059Earl JulieSmolkova BozenaKataki AgapiNjHacINjHaclBOOK9910719772503321Genetic and Epigenetic Regulations of Tumor Progression and Metastasis3360304UNINA