03104nam 2200481 450 991071736990332120221025161618.0(CKB)2670000000429627(NjHacI)992670000000429627(OCoLC)833312525(EXLCZ)99267000000042962720221025d2012 uy 0engur|||||||||||txtrdacontentcrdamediacrrdacarrierPredictors and consequences of severe hypoglycemia in adults with diabetes a systematic review of the evidence /Hanna E. Bloomfield [and seven others]Washington, District of Columbia :Department of Veterans Affairs (US),[2012]©20121 online resource (iii, 163 pages) illustrations"Evidence-based synthesis program.""April 2012."Includes bibliographical references.Prevalence of type 2 diabetes is increasing at an alarming pace, fueled by the rising rates of overweight and obesity in many populations. In the VA healthcare system, the prevalence of diabetes was 20% in fiscal year 2000 and is now estimated at nearly 25%. Although people with diabetes have a substantially increased risk of cardiovascular disease (CVD), recent trials show that intensive glucose lowering does not reduce the risk of CVD death or all-cause mortality although it reduces the risk of microvascular complications (nephropathy, retinopathy and neuropathy) and possibly non-fatal myocardial infarction. Intensive glucose control also increases the risk of hypoglycemic episodes. Several recent meta-analyses of the trials comparing intensive to conventional glucose control concluded that intensive control is associated with a 2-2.5 fold increased risk of severe hypoglycemia. The reviews however have not included smaller randomized trials, trials focused on the comparison of specific drug regimens, and non-randomized trials. We conducted the current review to provide broader insight into the incidence of, the risk factors for, and the clinical and social impact of severe hypoglycemia in adults with type 2 diabetes treated with glucose lowering medications.Predictors and consequences of severe hypoglycemia in adults with diabetesDiabeticsDiabeticsDiet therapyUnited StatesfastDiabetics.DiabeticsDiet therapy.616.462025Bloomfield Hanna E.1353456United States.Department of Veterans Affairs.Health Services Research and Development Service,Quality Enhancement Research Initiative (U.S.)Minneapolis VA Health Care System (U.S.).VA Evidence Synthesis Program.Evidence-based Synthesis Program (U.S.)NjHacINjHaclBOOK9910717369903321Predictors and consequences of severe hypoglycemia in adults with diabetes3254404UNINA