01604oam 2200397 450 991071699830332120211022141608.0(CKB)5470000002526208(OCoLC)1280150146(EXLCZ)99547000000252620820211022d2021 ua 0engur|||||||||||txtrdacontentcrdamediacrrdacarrierAddressing cybersecurity vulnerabilities facing our nation's physical infrastructure hearing before the Committee on Environment and Public Works, United States Senate, One Hundred Seventeenth Congress, first session, July 21, 2021Washington :U.S. Government Publishing Office,2021.1 online resource (iii, 102 pages) color illustrationsS. hrg. ;117-74Includes bibliographical references.Addressing cybersecurity vulnerabilities facing our nation's physical infrastructure Infrastructure (Economics)Security measuresUnited StatesCyberterrorismUnited StatesPreventionInteragency coordinationUnited StatesLegislative hearings.lcgftInfrastructure (Economics)Security measuresCyberterrorismPrevention.Interagency coordinationGPOGPOGPOBOOK9910716998303321Addressing cybersecurity vulnerabilities facing our nation's physical infrastructure3537127UNINA04472nam 22006015 450 991043785180332120200701071828.01-4614-7953-310.1007/978-1-4614-7953-6(CKB)3710000000019035(EBL)1466725(SSID)ssj0001004911(PQKBManifestationID)11636713(PQKBTitleCode)TC0001004911(PQKBWorkID)11051048(PQKB)11037954(DE-He213)978-1-4614-7953-6(MiAaPQ)EBC1466725(PPN)17242030X(EXLCZ)99371000000001903520130913d2013 u| 0engur|n|---|||||txtccrMultiple Sclerosis Immunology A Foundation for Current and Future Treatments /edited by Takashi Yamamura, Bruno Gran1st ed. 2013.New York, NY :Springer New York :Imprint: Springer,2013.1 online resource (468 p.)Description based upon print version of record.1-4614-7952-5 Th17 cells in autoimmune inflammation and demyelination in the central nervous system -- Regulatory T cells in MS -- T-bet: A critical regulator of encephalitogenic T Cells -- Antigen-presenting cells in the Central Nervous System -- The role of B cells in multiple sclerosis -- Diet, gut flora and multiple sclerosis: current research and future perspectives -- GM-CSF in autoimmune inflammation of the central nervous system -- The role of Toll-like receptors in multiple sclerosis and experimental autoimmune encephalomyelitis -- Macrophages and microglia in experimental autoimmune encephalomyelitis and multiple sclerosis -- Genetics of multiple sclerosis -- Gene expression profiling and pathway analysis for identification of molecular targets in MS -- Systems biology for the study of multiple sclerosis -- Checkpoints in the development of pathogenic and regulatory T cells in Experimental Autoimmune Encephalomyelitis—a basis for current future interventions in MS -- Modeling MS in non-human primates -- A novel concept of treatment in MS: targeting both oligodendrocyte death and inflammatory processes by inhibiting poly (ADP-Ribose) polymerase -- Association of MS with other autoimmune diseases -- Current and future treatments of Multiple Sclerosis -- Targeting CD52 for the treatment of Multiple Sclerosis -- Haematopoietic stem cells for the treatment of MS -- Mesenchymal stem cells for the treatment of Multiple Sclerosis.The availability of powerful genome-wide association study technology, during the last five years, has shown that most of the “new” MS susceptibility loci are immune-response genes. It is clear that there is much novelty in the field of MS immunology, which has served as an impetus to invest in new therapies. Notably, most if not all of these are immunotherapies. Even the equally exciting field of cell-based therapies and neuro-regeneration may well rely on cells or growth factors that are no less immunomodulators than restorative of myelin and neural cell function.  Multiple Sclerosis Immunology  looks at MS immunology as the basis for the present and—even more—the future of treatments for this complex autoimmune condition. Both editors are immunologists, as well as clinical neurologists, and appreciate the importance of a sustained dialogue between basic and clinical scientists to ensure that “translation” is real and not just virtual.ImmunologyMedical geneticsMolecular biologyImmunologyhttps://scigraph.springernature.com/ontologies/product-market-codes/B14000Gene Functionhttps://scigraph.springernature.com/ontologies/product-market-codes/B12030Molecular Medicinehttps://scigraph.springernature.com/ontologies/product-market-codes/B1700XImmunology.Medical genetics.Molecular biology.Immunology.Gene Function.Molecular Medicine.616.834Yamamura Takashiedthttp://id.loc.gov/vocabulary/relators/edtGran Brunoedthttp://id.loc.gov/vocabulary/relators/edtBOOK9910437851803321Multiple Sclerosis Immunology2509601UNINA