01629nam 2200457 450 991071488310332120200601104937.0(CKB)4100000011468328(OCoLC)1155922417(EXLCZ)99410000001146832820200601d2020 ua 0engur|||||||||||txtrdacontentcrdamediacrrdacarrierReauthorizing federal highway programs issues and options[Washington, D.C.] :Congress of the United States, Congressional Budget Office,2020.1 online resource (approximately 27 pages) illustrations"May 2020.""Sheila Campbell prepared the report"--Page 27.Includes bibliographical references.Reauthorizing Federal Highway ProgramsRoadsUnited StatesCostsRoadsUnited StatesFinanceDecision makingTransportationFinanceForecastingFederal aid to transportationUnited StatesHighway planningUnited StatesRoadsCosts.RoadsFinanceDecision making.TransportationFinanceForecasting.Federal aid to transportationHighway planningCampbell Sheila(Sheila Marie),1386143United States.Congressional Budget Office,GPOGPOBOOK9910714883103321Reauthorizing federal highway programs3434798UNINA03674oam 2200577 450 991029835410332120190911103515.01-4899-8002-410.1007/978-1-4899-8002-1(OCoLC)868918491(MiFhGG)GVRL6YWD(EXLCZ)99371000000007369920131030d2014 uy 0engurun|---uuuuatxtccrObesity and breast cancer the role of dysregulated estrogen metabolism /Kristy A. Brown, Evan R. Simpson1st ed. 2014.New York :Springer,2014.1 online resource (ix, 56 pages) illustrations (chiefly color)SpringerBriefs in Cancer Research,2194-1173Description based upon print version of record.1-4899-8001-6 Includes bibliographical references.Introduction -- Estrogens, adiposity and the menopause -- The link between obesity and breast cancer: Epidemiological evidence -- Adipose-derived and obesity-related factors and breast cancer -- Estrogen biosynthesis -- Therapies aimed at breaking the linkage between obesity and breast cancer -- Conclusions.Obesity is a risk factor for breast cancer in older women. A number of adipose-derived and obesity-related factors have been shown to affect tumour cell growth. These include adipokines, insulin, IGF-1 and oestrogens. The majority of obesity-related postmenopausal breast cancers are oestrogen-dependent. Since the ovaries no longer produce oestrogens after menopause, and that circulating levels are negligible, it is evident that it is the oestrogens produced locally within the breast adipose that are responsible for the increased growth of breast cancer cells. Aromatase is the enzyme that converts androgens into oestrogens and its regulation is dependent on the activity of a number of tissue-specific promoters. Targeting oestrogen biosynthesis in obesity may be useful for the prevention of breast cancer. Aromatase inhibitors are efficacious at treating postmenopausal breast cancer and recent studies suggest that they may also be useful in the prevention setting. However, these compounds inhibit the catalytic activity of aromatase and as a consequence lead to a number of undesirable side-effects, including arthralgia and possible cognitive defects due to inhibition of aromatase in the bone and brain, respectively. Novel therapies, such as those employed to treat obesity-associated disease, including anti-diabetics, may prove successful at inhibiting aromatase specifically within the breast. This SpringerBrief will explore all of these issues in depth and the authors are in a unique position to write about this topic, having extensive experience in the field of aromatase research.SpringerBriefs in cancer research.EnzymesBreastCancerEtiologyBreastCancerRisk factorsMetabolismDisordersObesityOncologyEnzymes.BreastCancerEtiology.BreastCancerRisk factors.MetabolismDisorders.Obesity.Oncology.572.6616.99/4071Brown Kristy Aauthttp://id.loc.gov/vocabulary/relators/aut1059858Simpson E. R(Evan R.),MiFhGGMiFhGGBOOK9910298354103321Obesity and Breast Cancer2508876UNINA00864nam0 22002531i 450 UON0041149920231205104742.67820121009d1939 |0itac50 baitaIT|||| |||||Impero BritannicoOtto GrafFirenzeSansoni1939VI, 346 p.23 cm.Impero britannico storiaUONC082385FIITFirenzeUONL000052GRAFOttoUONV210484709037SansoniUONV246441650ITSOL20250919RICASIBA - SISTEMA BIBLIOTECARIO DI ATENEOUONSIUON00411499SIBA - SISTEMA BIBLIOTECARIO DI ATENEOSI EUR D D 0431 SI MR 10005 5 0431 Impero Britannico1341087UNIOR