01753nam 2200409I 450 991070774010332120161110132322.0(CKB)5470000002467149(OCoLC)962368393(EXLCZ)99547000000246714920161110j199305 ua 0engur|||||||||||txtrdacontentcrdamediacrrdacarrierRELAP5 assessment using LSTF test data SB-CL-18 /prepared by S. Lee, B.D. Chung, H.J. KimWashington, DC :Office of Nuclear Regulatory Research, U.S. Nuclear Regulatory Commission,May 1993.1 online resource (xii, 206 pages) illustrationsInternational agreement report ;NUREG/IA-0095"Korea Institute of Nuclear Safety, Safety Analysis Department.""May 1993.""Prepared as part of the Agreement on Research Participation and Technical Exchange under the International Thermal-Hydraulic Code Assessment and Application Program (ICAP).""Type of report: technical report"--Bibliographic data sheet.Includes bibliographical references (page 27).Pressurized water reactorsLoss of coolantComputer simulationPressurized water reactorsLoss of coolantComputer simulation.Lee Sukho1402929Chung B. D(Bub Dong),Kim H. J(Hho Jung),U.S. Nuclear Regulatory Commission.Office of Nuclear Regulatory Research,GPOGPOBOOK9910707740103321RELAP5 assessment using LSTF test data SB-CL-183474446UNINA04737nam 2200457z- 450 991068834430332120210212(CKB)3800000000216223(oapen)https://directory.doabooks.org/handle/20.500.12854/62652(oapen)doab62652(EXLCZ)99380000000021622320202102d2016 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierWhen Chemistry Meets Biology - Generating Innovative Concepts, Methods and Tools for Scientific Discovery in the Plant SciencesFrontiers Media SA20161 online resource (146 p.)Frontiers Research Topics2-88919-928-2 Biologically active small molecules have increasingly been applied in plant biology to dissect and understand biological systems. This is evident from the frequent use of potent and selective inhibitors of enzymes or other biological processes such as transcription, translation, or protein degradation. In contrast to animal systems, which are nurtured from drug research, the systematic development of novel bioactive small molecules as research tools for plant systems is a largely underexplored research area. This is surprising since bioactive small molecules bear great potential for generating new, powerful tools for dissecting diverse biological processes. In particular, when small molecules are integrated into genetic strategies (thereby defining "chemical genetics"), they may help to circumvent inherent problems of classical (forward) genetics. There are now clear examples of important, fundamental discoveries originating from plant chemical genetics that demonstrate the power, but not yet fully exploited potential, of this experimental approach. These include the unraveling of molecular mechanisms and critical steps in hormone signaling, activation of defense reactions and dynamic intracellular processes. The intention of this Research Topic of Frontiers in Plant Physiology is to summarize the current status of research at the interface between chemistry and biology and to identify future research challenges. The research topic covers diverse aspects of plant chemical biology, including the identification of bioactive small molecules through screening processes from chemical libraries and natural sources, which rely on robust and quantitative high-throughput bioassays, the critical evaluation and characterization of the compound's activity (selectivity) and, ultimately, the identification of its protein target(s) and mode-of-action, which is yet the biggest challenge of all. Such well-characterized, selective chemicals are attractive tools for basic research, allowing the functional dissection of plant signaling processes, or for applied purposes, if designed for protection of crop plants from disease. New methods and data mining tools for assessing the bioactivity profile of compounds, exploring the chemical space for structure-function relationships, and comprehensive chemical fingerprinting (metabolomics) are also important strategies in plant chemical biology. In addition, there is a continuing need for diverse target-specific bioprobes that help profiling enzymatic activities or selectively label protein complexes or cellular compartments. To achieve these goals and to add suitable probes and methods to the experimental toolbox, plant biologists need to closely cooperate with synthetic chemists. The development of such tailored chemicals that beyond application in basic research can modify traits of crop plants or target specific classes of weeds or pests by collaboration of applied and academic research groups may provide a bright future for plant chemical biology. The current Research Topic covers the breadth of the field by presenting original research articles, methods papers, reviews, perspectives and opinions.Botany & plant sciencesbicsscagricultural biotechnologybioactive small moleculeChemical BiologyChemical GeneticsHigh-Throughput Screeningphytohormoneplant growth regulatorPlant immune responsePlant-pathogen interactionTarget identificationBotany & plant sciencesErich Kombrinkauth1351524Markus KaiserauthBOOK9910688344303321When Chemistry Meets Biology - Generating Innovative Concepts, Methods and Tools for Scientific Discovery in the Plant Sciences3114740UNINA