02247oas 2200577 a 450 991070448290332120150910133637.0(CKB)5470000002440863(OCoLC)828627817(EXLCZ)99547000000244086320130227a20099999 oa engur|||||||||||txtrdacontentcrdamediacrrdacarrierPerformance and accountability report for FY ..[electronic resource][Washington, D.C.] United States Access Board1 online resourceUnited States Access Board performance and accountability report, independent auditor's report, and financial statementsPeople with disabilitiesGovernment policyUnited StatesPeriodicalsPeople with disabilitiesTransportationUnited StatesPeriodicalsBarrier-free designUnited StatesPeriodicalsTransportationBarrier-free designUnited StatesPeriodicalsPublic buildingsBarrier-free designUnited StatesPeriodicalsBarrier-free designfastPeople with disabilitiesGovernment policyfastPeople with disabilitiesTransportationfastPublic buildingsBarrier-free designfastTransportationBarrier-free designfastUnited StatesfastPeriodicals.fastPeople with disabilitiesGovernment policyPeople with disabilitiesTransportationBarrier-free designTransportationBarrier-free designPublic buildingsBarrier-free designBarrier-free design.People with disabilitiesGovernment policy.People with disabilitiesTransportation.Public buildingsBarrier-free design.TransportationBarrier-free design.GPOGPOOCLCFOCLCOGPOJOURNAL9910704482903321Performance and accountability report for FY3196440UNINA03352nam 22005895 450 991087466070332120240712125357.0978303159866110.1007/978-3-031-59866-1(CKB)32775325500041(MiAaPQ)EBC31526166(Au-PeEL)EBL31526166(DE-He213)978-3-031-59866-1(EXLCZ)993277532550004120240712d2024 u| 0engur|||||||||||txtrdacontentcrdamediacrrdacarrierThe Major Histocompatibility Complex (MHC/ HLA) in Medicine A Personal Recollection /by Federico Garrido1st ed. 2024.Cham :Springer International Publishing :Imprint: Springer,2024.1 online resource (116 pages)9783031598654 Includes bibliographical references.Chapter 1: The discovery of the Major Histocompatibility Complex (MHC): The H-2 in mice and the HLA in humans -- Chapter 2: The discovery of the biological function of the MHC -- Chapter 3: HLA genes and molecules -- Chapter 4: HLA in transplantation -- Chapter 5: HLA class-I loss and cancer Immune escape -- Chapter 6: HLA and disease association -- Chapter 7: HLA in population genetics.This book takes the reader on a journey through past and current research on the Major Histocompatibility Complex (MHC/HLA). It describes how it was discovered, what its biological function is and its application in medicine. The reader will learn about the molecular structure of the encoded molecules and different aspects of their role in medicine, including organ transplantation, their link to autoimmune diseases, cancer immunity, resistance to infectious diseases, and other related scientific areas, such as population genetics. In particular, the book focusses on the impact of MHC/HLA altered expression in tumours and their relevance in cancer immune escape and immunotherapy. It contains a large number of original figures and photographs of pioneers in the field, who made seminal contributions. Each chapter is supported by relevant key publications and enriched with a personal account of the early research that has contributed to our current understanding of the role of the major histocompatibility complex. This book is an excellent resource for all scientists in the biomedical life sciences who wish to gain insight into the discovery of the MHC/HLA and the role of this important genetic complex in health and disease.ImmunologyCancerGeneticsCancerGenetic aspectsImmunologyCancer BiologyGenetics and GenomicsCancer Genetics and GenomicsImmunology.Cancer.Genetics.CancerGenetic aspects.Immunology.Cancer Biology.Genetics and Genomics.Cancer Genetics and Genomics.616.079Garrido Federico995416MiAaPQMiAaPQMiAaPQ9910874660703321The Major Histocompatibility Complex (MHC4183988UNINA