02376oam 2200649I 450 991070375670332120151229103028.0(CKB)5470000002434154(OCoLC)905912995(EXLCZ)99547000000243415420150331d2015 uy 0engurmn|||||||||txtrdacontentcrdamediacrrdacarrierWhen going gets tough barriers and motivations affecting arts attendance /prepared by Margaret E. Blume-Kohout and Sara R. Leonard, with Jennifer L. Novak-LeonardWashington, DC :National Endowment for the Arts,2015.1 online resource (viii, 52 pages) color illustrationsNEA research report ;#59Revised from NEA research report #57."January 2015.""Prepared by Margaret E. Blume-Kohout and Sara R. Leonard of MBK Analytics, with Jennifer L. Novak-Leonard of the Cultural Policy Center and NORC at the University of Chicago."Includes bibliographical references (pages 51-52).When going gets tough ArtsUnited StatesCitizen participationStatisticsArts audiencesUnited StatesStatisticsArts surveysUnited StatesArts audiencesfastArtsCitizen participationfastArts surveysfastUnited StatesfastStatistics.fastStatistics.lcgftArtsCitizen participationArts audiencesArts surveysArts audiences.ArtsCitizen participation.Arts surveys.Blume-Kohout Margaret E.1389438Novak-Leonard Jennifer L(Jennifer Leigh),1977-1389439Leonard Sara R.National Endowment for the Arts,Irving B. Harris Graduate School of Public Policy Studies.Cultural Policy Center,NORC (Organization),TZATZAOCLCQGPOOCLCFOKNGPOBOOK9910703756703321When going gets tough3440992UNINA04960nam 22006975 450 991075138900332120251113192353.03-031-29223-510.1007/978-3-031-29223-1(MiAaPQ)EBC30787864(Au-PeEL)EBL30787864(DE-He213)978-3-031-29223-1(PPN)272917079(CKB)28505213100041(EXLCZ)992850521310004120231014d2023 u| 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierImmunotherapy for Head and Neck Cancer /edited by Anthony T. C. Chan, Brigette B.Y. Ma1st ed. 2023.Cham :Springer Nature Switzerland :Imprint: Springer,2023.1 online resource (151 pages)Cancer Immunotherapy,2662-8392 ;1Print version: Chan, Anthony T. C. Immunotherapy for Head and Neck Cancer Cham : Springer,c2023 9783031292224 Immunological Landscape of Head and Neck Cancer: Mechanisms of Immune Escape and the Tumor Microenvironment -- Drug Targets and Strategies in the Clinical Development of Immunotherapy for Head and Neck Cancer -- Immunotherapy in Locally Advanced Nasopharyngeal Carcinoma -- Immunotherapy in Recurrent and Metastatic Nasopharyngeal Carcinoma -- Beyond PD-1/PD-L1 Immune Checkpoint Inhibitors: Other Targets and Approaches for Head and Neck Cancer -- Translational and Clinical Approach to Combining Immunotherapy with Radiotherapy in the Treatment of Head and Neck Cancer -- Clinical Application of Immunotherapy in the Perioperative Management of Head and Neck Cancer -- The Role of Immune Checkpoint Inhibitors in the Treatment of Less Common Head and Neck Cancers -- Development of Predictive Biomarkers to Immunotherapy in Head and Neck Cancer. .This book is a comprehensive summary of the literature on the scientific rationale and clinical development of immunotherapy for head and neck cancers. Head and neck cancer is a biologically diverse group of cancers that bear a common hallmark - evasion of host immune surveillance through innate or acquired mechanisms. The etiological association between the Human Papilloma virus (HPV) and some squamous head and neck cancers, the Epstein-Barr virus (EBV) and nasopharyngeal cancer has provided further impetus for evaluating immunotherapy in this group of cancers. The successful development of anti-programmed cell death protein-1 (PD-1)/ ligand (PD-L1) and CTLA-4 antibodies in solid tumours has gradually brought immunotherapy into mainstream oncological practice in recent years. Besides immune-checkpoint proteins inhibitors, other forms of immunotherapy such as vaccines, EBV or HPV-targeting therapies and cellular therapies are actively being investigated in clinical trials, either alone or in combination with other conventional treatments such as radiotherapy, chemotherapy and surgery. In clinical setting, the practicing oncologist need to be familiar with some unusual patterns of immunological response such as pseudo-progression and hyper-progression in patients with head and neck cancers who are undergoing treatment with immune-checkpoint inhibitors. Furthermore, the unique side effects of immune-checkpoint inhibitors such as autoimmune toxicities need to be recognized early and treated expediently. The development of biomarkers in predicting response to immune-checkpoint inhibitors has played pivotal roles in selecting patients for immunotherapy in practice or as an enrichment strategy in clinical trials. There are now emerging data on the clinical utility of biomarkers such as PD-L1 expression (Combined Positive Score), gene signatures and tumor mutational burden. This book is an invaluable companion to all those who are involved in research and clinical management of patients with head and neck cancers from any endemic regions. .Cancer Immunotherapy,2662-8392 ;1ImmunotherapyOncologyMedical radiologySurgeryOtolaryngologyImmunotherapyOncologyRadiation OncologySurgeryOtorhinolaryngologyImmunotherapy.Oncology.Medical radiology.Surgery.Otolaryngology.Immunotherapy.Oncology.Radiation Oncology.Surgery.Otorhinolaryngology.615.37571.96Chan Anthony T. C1432798Ma Brigette B. Y1432799MiAaPQMiAaPQMiAaPQBOOK9910751389003321Immunotherapy for Head and Neck Cancer3577825UNINA