01592nam 2200433Ia 450 991070315560332120110428150526.0(CKB)4330000001914446(OCoLC)716257202(EXLCZ)99433000000191444620110428d2011 ua 0engurmn|||||||||txtrdacontentcrdamediacrrdacarrierNext steps for the FCEV learning demonstration project[electronic resource] /Keith Wipke ... [and others][Golden, Colo.] :National Renewable Energy Laboratory,[2011]1 online resource (21 pages) illustrations, mapsNREL/PR ;5600-50842Title from PDF title screen (NREL, viewed Apr. 26, 2011)."Fuel Cell & Hydrogen Energy Conference, Washington, DC.""February 16, 2011."Next Steps for the FCEV Learning Demonstration Project Fuel cellsResearchCongressesHydrogen carsResearchCongressesElectric vehiclesResearchCongressesConference papers and proceedings.lcgftFuel cellsResearchHydrogen carsResearchElectric vehiclesResearchWipke Keith B1387671National Renewable Energy Laboratory (U.S.)GPOGPOBOOK9910703155603321Next steps for the FCEV learning demonstration project3520601UNINA04615nam 22006735 450 991025392100332120260223210722.0981-10-3707-810.1007/978-981-10-3707-8(CKB)3710000001364744(DE-He213)978-981-10-3707-8(MiAaPQ)EBC4860941(PPN)201469979(EXLCZ)99371000000136474420170516d2017 u| 0engurnn#008mamaatxtrdacontentcrdamediacrrdacarrierCellular Osmolytes From Chaperoning Protein Folding to Clinical Perspectives /edited by Laishram Rajendrakumar Singh, Tanveer Ali Dar1st ed. 2017.Singapore :Springer Singapore :Imprint: Springer,2017.1 online resource (VII, 249 p. 36 illus., 16 illus. in color.)981-10-3706-X Includes bibliographical references at the end of each chapters.Polyols as exceptional Protein stabilizers -- Osmolyte mixtures versus individuals in protein folding and aggregation -- Molecular insights of Osmolyte-protein Interaction -- MDS simulation studies on osmolyte protein interactions -- Osmolytes as protein aggregation Modifiers -- Osmolytes as Nano-probes of conformational changes -- Inhibition of Protein fibrillation by Chemical chaperones: a Therapeutic strategy -- Osmolyte in Infectious Diseases -- Possible strategies for the therapeutic intervention of osmolyte in Cancer -- Antioxidant osmolytes -- Advances on the in vivo studies of the effect of osmolyte on various pathophysiological conditions -- TMAO in alpha Synuclein aggregation -- Osmolytes: from cell physiology to Disease Prevention -- Osmolytes in Cell-volume Regulation -- Role of Osmolytes in counteracting the deleterious effects of denaturant/pressure.This book provides essential insights into improving protein folding/stability, which is a result of the balance between the intra-molecular interactions of protein functional groups and their interactions with the solvent environment. Even a subtle change in the composition of the solvent environment will alter the fidelity of the protein folding process, and hostile environmental stresses represent one of the basic causes of challenges in protein folding or misfolding. Among the strategies employed in a wide range of species and cell types to circumvent the hostile environmental conditions is the elaboration of small organic molecules called osmolytes, and recent advances have revealed that certain specific osmolytes might be key biomarkers of cancer, infectious diseases and are useful in heterologous protein expression and vaccine flocculation. As such a large pool of data has been collected regarding their potential for therapeutic intervention in neurodegenerative diseases and other metabolic disorders caused by protein aggregation or proteiostasis failure.Biomedical engineeringCell physiologyProteinsCancerResearchBiochemistryBotanical chemistryBiomedical Engineering/Biotechnologyhttps://scigraph.springernature.com/ontologies/product-market-codes/B24000Cell Physiologyhttps://scigraph.springernature.com/ontologies/product-market-codes/L33010Protein-Ligand Interactionshttps://scigraph.springernature.com/ontologies/product-market-codes/L14060Cancer Researchhttps://scigraph.springernature.com/ontologies/product-market-codes/B11001Animal Biochemistryhttps://scigraph.springernature.com/ontologies/product-market-codes/L14013Plant Biochemistryhttps://scigraph.springernature.com/ontologies/product-market-codes/L14021Biomedical engineering.Cell physiology.Proteins.CancerResearch.Biochemistry.Botanical chemistry.Biomedical Engineering/Biotechnology.Cell Physiology.Protein-Ligand Interactions.Cancer Research.Animal Biochemistry.Plant Biochemistry.610.28Singh Laishram Rajendrakumaredthttp://id.loc.gov/vocabulary/relators/edtDar Tanveer Aliedthttp://id.loc.gov/vocabulary/relators/edtBOOK9910253921003321Cellular Osmolytes4264201UNINA