02140oam 2200505Ia 450 991069900170332120231020231918.0(CKB)5470000002399874(OCoLC)503109093(OCoLC)995470000002399874(EXLCZ)99547000000239987420100202d1997 ua 0engurmn|||||||||txtrdacontentcrdamediacrrdacarrierSuitability of Dry Bay, southeastern Alaska, as rearing habitat for juvenile salmon[electronic resource] /by A.G. Celewycz and A.C. WertheimerSeattle, Wash. :U.S. Dept. of Commerce, National Oceanic and Atmospheric Administration, National Marine Fisheries Service, Alaska Fisheries Science Center,[1997]1 online resource (vi, 19 pages) illustrations, mapsNOAA technical memorandum NMFS-AFSC ;73Title from title screen (viewed on Jan. 25, 2010)."April 1997."Includes bibliographical references.Chinook salmon fisheriesEconomic aspectsAlaskaDry Bay (Yakutat)FisheriesAlaskaDry Bay (Yakutat)Hydrologic factorsChinook salmon fisheriesAlaskaDry Bay (Yakutat)MeasurementChinook salmonEcologyAlaskaDry Bay (Yakutat)Chinook salmonEffect of water levels onAlaskaDry Bay (Yakutat)Dry Bay (Yakutat, Alaska)Chinook salmon fisheriesEconomic aspectsFisheriesHydrologic factors.Chinook salmon fisheriesMeasurement.Chinook salmonEcologyChinook salmonEffect of water levels onCelewycz Adrian G1400846Wertheimer Alex C1400847Alaska Fisheries Science Center (U.S.)GPOGPOGPOBOOK9910699001703321Suitability of Dry Bay, southeastern Alaska, as rearing habitat for juvenile salmon3468490UNINA04512nam 22006735 450 991086315390332120250325165636.09783030578145303057814310.1007/978-3-030-57814-5(CKB)4100000011569211(DE-He213)978-3-030-57814-5(MiAaPQ)EBC6387589(PPN)252510240(EXLCZ)99410000001156921120201109d2020 u| 0engurnn#008mamaatxtrdacontentcrdamediacrrdacarrierThe Science and Business of Drug Discovery Demystifying the Jargon /by Edward D. Zanders2nd ed. 2020.Cham :Springer International Publishing :Imprint: Springer,2020.1 online resource (XVII, 402 p. 102 illus., 20 illus. in color.)9783030578138 3030578135 Includes bibliographical references and index.Introduction -- PART 1: How Drugs are Discovered and Developed in the Pharmaceutical Industry -- Introduction to Drugs and Drug Targets -- Background to chemistry of small and large molecules -- Laying the foundations- Drug discovery from antiquity to the twenty first century -- Part II-The drug development pipeline – discovery to testing in humans -- Drug discovery pipeline overview -- Target discovery -- Medicinal chemistry -- Biotherapeutics -- Screening for hits -- Process chemistry and formulation -- Preclinical development -- Part III-The drug development pipeline – clinical trials to marketing authorisation -- Clinical trials -- Regulatory affairs and marketing approval -- Diagnostics and personalized medicine -- Putting it All Together: a drug development case history -- Part IV- The Global Pharmaceuticals Business -- Commercial aspects of drug development -- Challenges and responses -- Part V - Professional Interactions with the Drug Discovery Industry.-Professional Interactions with the Drug Discovery Industry: Technology Transfer Executives -- Recruitment Executives -- Pharmaceutical translators and Interpreters.The Science and Business of Drug Discovery is written for those who want to learn about the biopharmaceutical industry and its products whatever their level of technical knowledge. Its aim is to demystify the jargon used in drug development, but in a way that avoids over simplification and the resulting loss of key information. Each of the twenty chapters is illustrated with figures and tables which clarify some of the more technical points being made. Also included is a drug discovery case history which draws the relevant material together into a single chapter. In recognizing that it is difficult to navigate through the many external resources dealing with drug development, the book has been written to guide the reader towards the most appropriate information sources, including those listed in the two appendices. The following topics are covered: Different types of drugs: from small molecules to stem cells Background to chemistry ofsmall and large molecules Historical background to drug discovery, pharmacology and biotechnology The drug discovery pipeline: from target discovery to marketed medicine Commercial aspects of drug discovery Challenges to the biopharmaceutical industry and its responses Material of specific interest to technology transfer executives, recruiters and pharmaceutical translators .PharmacologyPharmacovigilancePharmaceutical chemistryChemistry, Physical and theoreticalBiotechnologyPharmacologyDrug Safety and PharmacovigilancePharmaceuticsTheoretical ChemistryBiotechnologyPharmacology.Pharmacovigilance.Pharmaceutical chemistry.Chemistry, Physical and theoretical.Biotechnology.Pharmacology.Drug Safety and Pharmacovigilance.Pharmaceutics.Theoretical Chemistry.Biotechnology.615.19Zanders Edward D.511858MiAaPQMiAaPQMiAaPQBOOK9910863153903321The science and business of drug discovery3562757UNINA