05232nam 22006371 450 991013897520332120210604103758.03-527-65896-33-527-65894-73-527-65897-1(CKB)2550000001172033(EBL)1420234(SSID)ssj0001164124(PQKBManifestationID)11677893(PQKBTitleCode)TC0001164124(PQKBWorkID)11180729(PQKB)11672917(OCoLC)868925861(MiAaPQ)EBC1420234(PPN)219783306(EXLCZ)99255000000117203320131113h20142014 uy 0engur|n|---|||||txtccrModern synthetic methods in carbohydrate chemistry from monosaccharides to complex glycoconjugates /edited by Daniel B. Werz, Sébastien VidalWeinheim :Wiley-VCH,[2014]©20141 online resource (407 p.)Description based upon print version of record.3-527-33284-7 1-306-22087-4 Includes bibliographical references and index.Cover; Title Page; Copyright; Contents; Foreword; Preface; List of Contributors; 1 De Novo Approaches to Monosaccharides and Complex Glycans; 1.1 Introduction; 1.2 De Novo Synthesis of Monosaccharides; 1.3 Iterative Pd-Catalyzed Glycosylation and Bidirectional Postglycosylation; 1.3.1 Bidirectional Iterative Pd-Catalyzed Glycosylation and Postglycosylation; 1.3.2 Synthesis of Monosaccharide Aminosugar Library; 1.4 Synthesis of Monosaccharide Azasugar; 1.5 Oligosaccharide Synthesis for Medicinal Chemistry; 1.5.1 Tri- and Tetrasaccharide Library Syntheses of Natural Product1.5.2 Anthrax Tetrasaccharide Synthesis1.6 Conclusion and Outlook; 1.7 Experimental Section; List of Abbreviations; Acknowledgments; References; 2 Synthetic Methodologies toward Aldoheptoses and Their Applications to the Synthesis of Biochemical Probes and LPS Fragments; 2.1 Introduction; 2.2 Methods to Construct the Heptose Skeleton; 2.2.1 Olefination of Dialdoses Followed by Dihydroxylation; 2.2.1.1 Olefination at C-5 Position of Pentodialdoses; 2.2.1.2 Olefination at C-1 Position of Hexoses; 2.2.1.3 Olefination at C-6 Position of Hexodialdoses; 2.2.2 Homologation by Nucleophilic Additions2.2.2.1 Elongation at C-6 of Hexoses2.2.2.2 Elongation at C-1 Position of Aldose; 2.2.3 Heptose de novo synthesis; 2.3 Synthesis of Heptosylated Oligosaccharides; 2.3.1 Synthesis of the Core Tetrasaccharide of Neisseria meningitidis Lipopolysaccharide; 2.3.2 Synthesis of a Branched Heptose- and Kdo-Containing Common Tetrasaccharide Core Structure of Haemophilus influenzae; 2.3.3 Synthesis of the Core Tetrasaccharide of Neisseria gonorrhoeae Lipopolysaccharide2.3.4 The Crich's Stereoselective β-Glycosylation Applied to the Synthesis of the Repeating Unit of the Lipopolysaccharide from Plesimonas shigelloides2.3.5 De Novo Approach Applied to the Synthesis of a Bisheptosylated Tetrasaccharide; 2.4 Synthesis of Heptosides as Biochemical Probes; 2.4.1 Bacterial Heptose Biosynthetic Pathways; 2.4.2 Artificial D-Heptosides as Inhibitors of HldE and GmhA; 2.4.3 Inhibition Studies of Heptosyltransferase WaaC; 2.5 Conclusions; 2.6 Experimental Part; 2.6.1 Typical Synthesis of a D-glycero-Heptoside by Dihydroxylation of a C6-C7 Alkene2.6.1.1 Phenyl 1-deoxy-2,3,4-tri-O-benzyl-1-thio-D-glycero-α-D-mannoheptopyranoside (167)2.6.2 Typical Synthesis of a L-glycero-Heptoside by Addition of Grignard Reagent Followed by a Tamao-Fleming Oxidation; 2.6.2.1 Methyl 2,3,4-tri-O-benzyl-7-(phenyldimethyl)silane-7-deoxy-L-glycero-α-D-manno-heptopyranoside (170); 2.6.2.2 Methyl 2,3,4-tri-O-benzyl-L-glycero-α-D-manno-heptopyranoside (171); List of Abbreviations; Acknowledgments; References; 3 Protecting-Group-Free Glycoconjugate Synthesis: Hydrazide and Oxyamine Derivatives in N-Glycoside Formation; 3.1 Introduction3.2 Glycosyl Hydrazides (1-(Glycosyl)-2-acylhydrazines)The fields of glycochemistry and glycoscience are rich and varied and where much can be learned from Nature. As Nature is not always able to produce carbohydrates in quantities useful for not only in research but also as therapeutic agents, new ways need to be found to optimize the yield. This book presents an overview of the latest developments in the field of carbohydrates, ranging from de-novo approaches via cyclodextrin chemistry to the synthesis of such highly complex glycoconjugates as glycosphingolipids and GPI anchors. The main emphasis remains on the synthetic aspects making tCarbohydratesSynthesisCarbohydratesCarbohydratesSynthesis.Carbohydrates.547.3Vidal Sébastien905789Werz Daniel B905790MiAaPQMiAaPQMiAaPQBOOK9910138975203321Modern synthetic methods in carbohydrate chemistry2025988UNINA01454nem 2200421Ia 450 991069689280332120080721171222.0(CKB)5470000002381950(OCoLC)234318088(EXLCZ)99547000000238195020080721d2005 ua engb|||||||||||||||||||||gurcn|||||||||crdrdacontentcrdamediacrrdacarrierAfghanistan from space[electronic resource] NASA astronaut photo, December 31, 2002 /photo annotated by Dan Miller; United States Agency for International Development ; RAMP GIS Unit[Washington, D.C.] :U.S. Agency for International Development,[2005]1 remote-sensing image digital, PDF fileRelief shown by shading.Title from title screen (viewed on July 21, 2008)."August 2005."Afghanistan from space AfghanistanMapsRemote-sensing maps.lcgftMaps.lcgftMiller Dan1401214United States.National Aeronautics and Space Administration.Rebuilding Agricultural Markets Program (Afghanistan)GPOGPOBOOK9910696892803321Afghanistan from space3469594UNINA00687nas 2200241zu 450 991106941850332120260312144850.0(CKB)45725102200041(EXLCZ)994572510220004120260312cuuuuuuuu || |engur|||||||||||Geopolitic and Geostrategic IntelligenceMorocco: Ecole Nationale de Commerce et de Gestion (ENCG)2605-6496 geopoliticsgeostrategyregional powercorporate strategiesJOURNAL9911069418503321Geopolitic and Geostrategic Intelligence4551891UNINA