01899nam 2200373 450 991068841810332120230623121215.0(CKB)5400000000040557(NjHacI)995400000000040557(EXLCZ)99540000000004055720230623d2020 uy 0engur|||||||||||txtrdacontentcrdamediacrrdacarrierAmyotrophic Lateral Sclerosis /edited by Muralidhar L. HegdeLondon, United Kingdom :IntechOpen,2020.1 online resource (160 pages) illustrations1-83880-582-6 A flurry of recent research on the role of the RNA/DNA-binding proteins TDP-43 and FUS as well as a dozen other factors (e.g., C9ORF72 and profilin) has led to a new paradigm in our understanding of the pathobiology of the motor neuron disease, Amyotrophic Lateral Sclerosis (ALS). How these factors trigger neuromuscular dysfunction is critical for developing more effective ALS therapeutics. The 'gain-of-toxicity' or 'loss-of-function' of these etiological factors is a key question. Recent studies on the imbalance in genome damage versus repair have opened avenues for potential DNA repair-based therapeutics. This book highlights emerging science in the area of ALS and discusses key approaches and mechanisms essential for developing a cure for ALS.Amyotrophic Lateral Sclerosis Amyotrophic lateral sclerosisAmyotrophic lateral sclerosisTreatmentAmyotrophic lateral sclerosis.Amyotrophic lateral sclerosisTreatment.616.83Hegde Muralidhar L.NjHacINjHaclBOOK9910688418103321Amyotrophic lateral sclerosis2004420UNINA