02017nam 2200361 450 991068834020332120230702065843.0(CKB)3800000000216533(NjHacI)993800000000216533(EXLCZ)99380000000021653320230702d2017 uy 0engur|||||||||||txtrdacontentcrdamediacrrdacarrierNovel Pharmacological Inhibitors for Bacterial Protein Toxins /edited by Holger BarthBasel :MDPI - Multidisciplinary Digital Publishing Institute,2017.1 online resource (v, 103 pages)3-03842-431-5 Many medically relevant bacteria cause severe human and animal diseases because they produce and release protein toxins that target mammalian cells. Because the toxin-induced cell damage is the reason for the clinical symptoms, the targeted pharmacological inhibition of the cytotoxic mode of action of bacterial toxins should prevent or cure the respective toxin-associated disease. Toxin inhibitors might be beneficial when the toxin acts in the absence of the producing bacteria (e.g., food poisoning), but also in combination with antibiotics in infectious diseases when the toxin-producing bacteria are present. The focus of this Special Issue of Toxins is on the development and characterization of novel inhibitors against bacterial toxins, e.g., toxin neutralizing antibodies, peptides or small compounds, as well as toxin pore blockers, which interfere with bacterial toxins and thereby protect cells from intoxication.Bacterial proteinsBacterial toxinsBacterial proteins.Bacterial toxins.572.69Barth HolgerNjHacINjHaclBOOK9910688340203321Novel Pharmacological Inhibitors for Bacterial Protein Toxins3114709UNINA