01545nam2 22003373i 450 VAN024274920230712094021.24N978331919186720220311d2015 |0itac50 baengCH|||| |||||1 / editor Lei Liu. - Cham : Springer, 2015 VII, 270 p. :001VAN00712532001 Topics in current chemistry210 BerlinSpringer362001VAN02426092001 Protein Ligation and Total Synthesiseditors Lei Liu210 ChamSpringer2015215 volumiill.24 cm1CHChamVANL001889572.6Proteine22540Chimica generale22615.19Chimica farmaceutica. Tecnologia farmaceutica. Chimica medica22661Chimica organica applicata22LiuLeiVANV198437Springer <editore>VANV108073650ITSOL20240614RICAhttps://rd.springer.com/book/10.1007/978-3-319-19186-7E-book - Accesso al full-text attraverso riconoscimento IP di Ateneo, proxy e/o ShibbolethBIBLIOTECA DEL DIPARTIMENTO DI SCIENZE E TECNOLOGIE AMBIENTALI BIOLOGICHE E FARMACEUTICHEIT-CE0101VAN17NVAN0242749BIBLIOTECA DEL DIPARTIMENTO DI SCIENZE E TECNOLOGIE AMBIENTALI BIOLOGICHE E FARMACEUTICHE17CONS e-book 2219 17BIB2219/214 214 20220311 161339UNICAMPANIA02664nam 2200385z- 450 991068823800332120210211(CKB)3710000000612069(oapen)https://directory.doabooks.org/handle/20.500.12854/48416(oapen)doab48416(EXLCZ)99371000000061206920202102d2014 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierGenome-wide view on the physiology of vitamin DFrontiers Media SA20141 online resource (194 p.)Frontiers Research Topics2-88919-349-7 The main physiological actions of the biologically most active metabolite of vitamin D, 1a,25-dihydroxyvitamin D3(1a,25(OH)2D3), are calcium and phosphorus uptake and transport and thereby controlling bone formation. Other emergent areas of 1a,25(OH)2D3 action are in the control of immune functions, cellular growth and differentiation. This fits both with the widespread expression of the VDR and the above described consequences of vitamin D deficiency. Transcriptome-wide analysis indicated that per cell type between 200 and 600 genes are primary targets of vitamin D. Since most of these genes respond to vitamin D in a cell-specific fashion, the total number of vitamin D targets in the human genome is far higher than 1,000. This is supported by the genome-wide view on VDR binding sites in human lymphocytes, monocytes, colon and hepatic cells. All genomic actions of 1a,25(OH)2D3 are mediated by the transcription factor vitamin D receptor (VDR) that has been the subject of intense study since the 1980's. Thus, vitamin D signaling primarily implies the molecular actions of the VDR. In this research topic, we present in 15 chapters different perspectives on the action of vitamin D and its receptor, such as the impact of the genomewide distribution of VDR binding loci, ii) the transcriptome- and proteome-wide effects of vitamin D, iii) the role of vitamin D in health, iv) tissue-specific functions of vitamin D and v) the involvement of vitamin D in different diseases, such as infections, autoimmune diseases, diabetes and different types of cancer.PhysiologybicsscGenomicsImmune SystemPhysiologyVitamin Dvitamin D receptorPhysiologyCarsten Carlbergauth849346BOOK9910688238003321Genome-wide view on the physiology of vitamin D3122472UNINA