03858nam 2200457z- 450 991068823280332120210211(CKB)3800000000216278(oapen)https://directory.doabooks.org/handle/20.500.12854/41778(oapen)doab41778(EXLCZ)99380000000021627820202102d2016 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierBad Bugs in the XXIst Century: Resistance Mediated by Multi-Drug Efflux Pumps in Gram-Negative BacteriaFrontiers Media SA20161 online resource (193 p.)Frontiers Research Topics2-88919-931-2 The discovery of antibiotics represented a key milestone in the history of medicine. However, with the rise of these life-saving drugs came the awareness that bacteria deploy defence mechanisms to resist these antibiotics, and they are good at it. Today, we appear at a crossroads between discovery of new potent drugs and omni-resistant superbugs. Moreover, the misuse of antibiotics in different industries has increased the rate of resistance development by providing permanent selective pressure and, subsequently, enrichment of multidrug resistant pathogens. As a result, antimicrobial resistance has now become an urgent threat to public health worldwide (http://www.who.int/drugresistance/documents/surveillancereport/en/). The development of multidrug resistance (MDR) in an increasing number of pathogens, including Pseudomonas, Acinetobacter, Klebsiella, Salmonella, Burkholderia, and other Gram-negative bacteria is a most severe issue. Membrane efflux pump complexes of the Resistance-Nodulation-cell Division (RND) superfamily play a key role in the development of MDR in these bacteria. RND pumps, together with other transporters, contribute to intrinsic and acquired resistance to most, if not all, of the antimicrobial compounds available in our drug arsenal. Given the enormous drug polyspecificity of MDR efflux pumps, studies on their mechanism of action are extremely challenging, and this has negatively impacted both the development of new antibiotics that are able to evade these efflux pumps as well as the design of pump inhibitors. The collection of articles in this eBook, published as a Research Topic in Frontiers in Microbiology, section of Antimicrobials, Resistance, and Chemotherapy, aims to update the reader about the latest advances on the structure and function of RND efflux transporters, their roles in the overall multidrug resistance phenotype of Gram-negative pathogens, and on strategies to inhibit their activities. A deeper understanding of the mechanisms by which RND efflux pumps, alone or synergistically with other efflux pumps, are able to limit the concentration of antimicrobial compounds inside the bacterial cell, may pave the way for new, more directed, inhibitor and antibiotic design to ultimately overcome antimicrobial resistance by Gram-negatives.Bad Bugs in the XXIst CenturyMicrobiology (non-medical)bicsscantibiotic resistancebacterial resistance mechanismsefflux pumpsGram-Negative Bacteriamulti-drug-resistant pathogensResistance-Nodulation Division transportersSuperbugsMicrobiology (non-medical)Hiroshi Nikaidoauth79841Attilio Vittorio VargiuauthKlaas Martinus PosauthKeith PooleauthBOOK9910688232803321Bad Bugs in the XXIst Century: Resistance Mediated by Multi-Drug Efflux Pumps in Gram-Negative Bacteria3205451UNINA02006oam 2200469z 450 991040984150332120241120175415.0(CKB)4100000011343914(oapen)https://directory.doabooks.org/handle/20.500.12854/28070(oapen)doab28070(EXLCZ)99410000001134391420200110d2012 uy 0engurcn#nnnauuuurdacontentrdamediardacarrierThe power of one on one human libraries and the challenges of antiracism work /Tanja Dreher, Jemima MowbrayBroadwayUTS ePRESS2012Broadway, NSW, Australia :UTS ePRESS,[2012]1 online resource (ii, 72 pages) illustrationsUTS Shopfront monograph series,1834 2035 ;no 71-86365-426-7 Includes bibliographical references."This book provides an overview of the innovative social inclusion initiatives known as human or living libraries. It is the first comprehensive and independent analysis of Human Libraries in Australia. The book provides an overview of Human Library practices and identifies key challenges for policymakers and practitioners while contributing to scholarly debates on anti-racism work and on the benefits and limits of cross-cultural contact or dialogue within that work."--Publisher's website.UTS shopfront monograph series ;no 71834 2035.Power of One on OneSocial interactionAustraliaLibraries and communityAnti-racismSocial interactionLibraries and community.Anti-racism.Dreher Tanja975233Mowbray JemimaNjRocCCSNjRocCCSNTSMBOOK9910409841503321The power of one on one2220823UNINA