02415oam 2200457 450 991079590240332120190911112719.01-61472-968-9(OCoLC)878969649(MiFhGG)GVRL8FDU(EXLCZ)99378000000005657820130807d2013 uy 0engurun|---uuuuatxtccrEnergy industries and sustainability /general editor, Ray C. Anderson ; editors, Klaus Bosselmann [and seventeen others]Great Barrington, MA :Berkshire,2013.1 online resource (viii, 171 pages) color illustrationsBerkshire essentialsBibliographic Level Mode of Issuance: Monograph1-61472-990-5 Includes bibliographical references and index.Introduction to renewable energy -- Algae -- Aluminum -- Cap-and-trade legislation -- Carbon footprint -- Coal -- Energy and theology -- Energy conservation incentives -- Energy efficiency measurement -- Energy industries : bioenergy -- Energy industries : geothermal -- Energy industries : hydroelectric -- Energy industries : hydrogen and fuel cells -- Energy industries : natural gas -- Energy industries : nuclear -- Energy industries : solar -- Energy industries : wave and tidal -- Energy industries : wind -- Energy labeling -- Energy subsidies -- Investment, CleanTech -- Investment law, energy -- Iron ore -- Lighting, indoor -- Lithium -- Materials substitution -- Mining -- Petroleum -- Polluter pays principle -- Shale gas extraction -- Sugarcane -- Thorium -- Uranium -- Utilities regulation.This book covers the exploitation of energy resources--such as coal, petroleum, and wood--and the innovations that can provide the energy we need for a cleaner, safer, and more sustainable future.Berkshire essentials.Energy industriesEnvironmental aspectsSustainabilityEnergy industriesEnvironmental aspects.Sustainability.333Dernbach John C.1118548Anderson Ray C.Bosselmann KlausMiFhGGMiFhGGBOOK9910795902403321Energy industries and sustainability3736319UNINA03858nam 2200457z- 450 991068823280332120210211(CKB)3800000000216278(oapen)https://directory.doabooks.org/handle/20.500.12854/41778(oapen)doab41778(EXLCZ)99380000000021627820202102d2016 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierBad Bugs in the XXIst Century: Resistance Mediated by Multi-Drug Efflux Pumps in Gram-Negative BacteriaFrontiers Media SA20161 online resource (193 p.)Frontiers Research Topics2-88919-931-2 The discovery of antibiotics represented a key milestone in the history of medicine. However, with the rise of these life-saving drugs came the awareness that bacteria deploy defence mechanisms to resist these antibiotics, and they are good at it. Today, we appear at a crossroads between discovery of new potent drugs and omni-resistant superbugs. Moreover, the misuse of antibiotics in different industries has increased the rate of resistance development by providing permanent selective pressure and, subsequently, enrichment of multidrug resistant pathogens. As a result, antimicrobial resistance has now become an urgent threat to public health worldwide (http://www.who.int/drugresistance/documents/surveillancereport/en/). The development of multidrug resistance (MDR) in an increasing number of pathogens, including Pseudomonas, Acinetobacter, Klebsiella, Salmonella, Burkholderia, and other Gram-negative bacteria is a most severe issue. Membrane efflux pump complexes of the Resistance-Nodulation-cell Division (RND) superfamily play a key role in the development of MDR in these bacteria. RND pumps, together with other transporters, contribute to intrinsic and acquired resistance to most, if not all, of the antimicrobial compounds available in our drug arsenal. Given the enormous drug polyspecificity of MDR efflux pumps, studies on their mechanism of action are extremely challenging, and this has negatively impacted both the development of new antibiotics that are able to evade these efflux pumps as well as the design of pump inhibitors. The collection of articles in this eBook, published as a Research Topic in Frontiers in Microbiology, section of Antimicrobials, Resistance, and Chemotherapy, aims to update the reader about the latest advances on the structure and function of RND efflux transporters, their roles in the overall multidrug resistance phenotype of Gram-negative pathogens, and on strategies to inhibit their activities. A deeper understanding of the mechanisms by which RND efflux pumps, alone or synergistically with other efflux pumps, are able to limit the concentration of antimicrobial compounds inside the bacterial cell, may pave the way for new, more directed, inhibitor and antibiotic design to ultimately overcome antimicrobial resistance by Gram-negatives.Bad Bugs in the XXIst CenturyMicrobiology (non-medical)bicsscantibiotic resistancebacterial resistance mechanismsefflux pumpsGram-Negative Bacteriamulti-drug-resistant pathogensResistance-Nodulation Division transportersSuperbugsMicrobiology (non-medical)Hiroshi Nikaidoauth79841Attilio Vittorio VargiuauthKlaas Martinus PosauthKeith PooleauthBOOK9910688232803321Bad Bugs in the XXIst Century: Resistance Mediated by Multi-Drug Efflux Pumps in Gram-Negative Bacteria3205451UNINA