02046nam 2200373 450 991068820610332120230630183013.010.5772/intechopen.91555(CKB)5400000000045725(NjHacI)995400000000045725(EXLCZ)99540000000004572520230630d2021 uy 0engur|||||||||||txtrdacontentcrdamediacrrdacarrierApplications of RNA-Seq in Biology and Medicine /Irina Vlasova-St Louis, editorLondon :IntechOpen,2021.1 online resource (142 pages)1-83962-816-2 This book evaluates and comprehensively summarizes the scientific findings that have been achieved through RNA-sequencing (RNA-Seq) technology. RNA-Seq transcriptome profiling of healthy and diseased tissues allows FOR understanding the alterations in cellular phenotypes through the expression of differentially spliced RNA isoforms. Assessment of gene expression by RNA-Seq provides new insight into host response to pathogens, drugs, allergens, and other environmental triggers. RNA-Seq allows us to accurately capture all subtypes of RNA molecules, in any sequenced organism or single-cell type, under different experimental conditions. Merging genomics and transcriptomic profiling provides novel information underlying causative DNA mutations. Combining RNA-Seq with immunoprecipitation and cross-linking techniques is a clever multi-omics strategy assessing transcriptional, post-transcriptional and post-translational levels of gene expression regulation.Nucleotide sequenceCyclic nucleotidesNucleotide sequence.Cyclic nucleotides.572.8633Vlasova-St Louis IrinaNjHacINjHaclBOOK9910688206103321Applications of RNA-Seq in Biology and Medicine2824887UNINA