05240nam 2200613Ia 450 991014473160332120180718143405.01-280-51966-597866105196683-527-60386-73-527-60431-6(CKB)1000000000377236(EBL)481910(OCoLC)68571336(SSID)ssj0000209800(PQKBManifestationID)11174311(PQKBTitleCode)TC0000209800(PQKBWorkID)10265696(PQKB)10534710(MiAaPQ)EBC481910(EXLCZ)99100000000037723620040510d2004 uy 0engur|n|---|||||rdacontentrdamediardacarrierNeuroprotection[electronic resource] models, mechanisms and therapies /edited by Mathias BährWeinheim Wiley-VCHc20041 online resource (391 p.)Description based upon print version of record.3-527-30816-4 Includes bibliographical references and index.Neuroprotection Models, Mechanismsand Therapies; Preface; Contents; List of Contributors; I Neurological Disorders - Epidemiology, Clinical Overview, and Model Systems; 1 Stroke; Abstract; 1.1 Introduction; 1.2 The Penumbra Concept; 1.3 Excitotoxicity; 1.4 Oxygen Free Radicals; 1.5 Tissue Acidosis; 1.6 Peri-infarct Depolarizations; 1.7 Inflammation; 1.8 Damage to the Blood-Brain-Barrier; 1.9 Programmed Cell Death and Apoptosis; 1.10 Ischemia-induced DNA Damage, DNA Repair, and p53 as Genotoxic Sensor; 1.11 Epigenetics; 1.12 Gene Expression; 1.13 Cell Replacement1.14 Endogenous Neuroprotection - Ischemic Tolerance1.15 Stroke Induced Immune Depression (SIDS); 1.16 Conclusion; References; 2 Parkinson's Disease; 2.1 Epidemiology of Parkinson's Disease; 2.1.1 Genetic Contribution; 2.1.2 Environmental Factors; 2.2 Oxidative Stress In Parkinson's Disease; 2.3 Role of Alpha-Synuclein in Parkinson's Disease; 2.3.1 Alpha-Synuclein in Lewy Bodies; 2.3.2 Alpha-Synuclein and Oxidative Stress; 2.4 The Involvement of Proteosome in PD; 2.4.1 Parkin Involvement in PD; 2.5 Other Genes Involved in Familial Parkinson's Disease; 2.6 Neurotoxic PD Models2.6.1 Oxidative Stress2.6.2 Dopamine Homeostasis/Complex I; 2.6.3 Proteasome; 2.7 Genetic Models of Parkinson's Disease; 2.7.1 Alpha-Synuclein Overexpressing Transgenic Animals; 2.7.2 Parkin-related Genetic Models; 2.7.3 Viral Vectors for In Vivo Gene Transfer of Disease-related Proteins to the CNS; 2.7.3.1 Local Overexpression of alpha-synuclein; 2.7.3.2 Local Overexpression of Parkin-related Proteins; Acknowledgements; References; 3 Amyotrophic Lateral Sclerosis; 3.1 Human Motor Neuron Diseases; 3.1.1 Familial ALS Linked to SOD1 Mutations; 3.1.2 Juvenile ALS Linked to Alsin Mutations3.2 Cell Culture Models of Motoneuron Degeneration3.2.1 Neuronal Cell Lines; 3.2.2 Isolated Motoneuron Cultures; 3.2.3 Organotypic Cultures; 3.3 Animal Models of Motor Neuron Disease; 3.3.1 Axotomy Models; 3.2 Mutant SOD1 Mice; 3.3.3 pmn Mice; 3.4 Future Neuroprotective Approaches; 3.4.1 Axonal Protection; 3.4.2 Mutant SOD1 Knockdown by RNA Interference; 3.5 Conclusion; References; 4 Alzheimer's Disease and Other Neurodegenerative Diseases; Abstract; 4.1 Introduction; 4.2 Transgenic Invertebrates; 4.3 Transgenic Mice; 4.3.1 Tyrosine Hydroxylase (TH) Promoter4.3.2 Platelet-derived Growth Factor-β (PDGFβ) Promoter4.3.3 Thy1 Promoter; 4.3.4 Prion Protein (PrP) Promoter; 4.3.5 Glial Expression; 4.4 Viral Models; 4.5 Conclusion and Outlook; References; 5 CNS Inflammation; 5.1 Introduction; 5.2 The Pathologic Characteristics of the MS Plaque; 5.3 Axonal Pathology in MS; 5.4 Neuronal Pathology in Multiple Sclerosis; 5.5 Lessons from Animal Models; References; 6 Neurotrauma; 6.1 Introduction; 6.2 In Vivo Models; 6.2.1 Static Brain Injury Models; 6.2.2 Dynamic Brain Injury Models; 6.2.2.1 Indirect Dynamic Brain Injury; 6.2.2.2 Direct Dynamic Brain Injury6.2.3 Combined Neurotrauma ModelsIn this first book to cover model systems, molecular mechanisms and clinical trials all in one volume internationally renowned scientists and clinicians provide a comprehensive treatment of neuroprotective strategies for all important neurological disorders.Following an overview of neurodegenerative, traumatic, and ischemic disorders, the book goes on to cover in vitro and animal model systems as well as cellular and molecular mechanisms. An extremely helpful analysis of clinical studies explains reasons for their success and failure, and the whole is rounded off with a look at the currentNervous systemDiseasesTreatmentMolecular neurobiologyElectronic books.Nervous systemDiseasesTreatment.Molecular neurobiology.616.806Bähr Mathias918219MiAaPQMiAaPQMiAaPQBOOK9910144731603321Neuroprotection2058849UNINA01243nam a22002651i 450099100362264970753620040518091604.0040802s1845 it |||||||||||||||||ita b13101936-39ule_instARCHE-105454ExLBiblioteca InterfacoltàitaA.t.i. Arché s.c.r.l. Pandora Sicilia s.r.l.956.9301Sereno, Bartolomeo489698Commentari della guerra di Cipro e della lega dei principi cristiani contro il Turco /di Bartolomeo Sereno ; ora per la prima volta pubblicati da ms. autografo con note e documenti per cura de' monaci della badia cassinese[S.l.] :pe' tipi di Monte Cassino,1845XLVI, 438 p. ;27 cmBattaglia di Lepanto. 1571Guerra di Cipro. 1571Benedettini <Monte Cassino>.b1310193602-04-1405-08-04991003622649707536LE002 Fondo Giudici L 134512002000337771le002C. 1-E0.00-no 00000.i1373620605-08-04Commentari della guerra di Cipro e della lega dei principi cristiani contro il Turco306455UNISALENTOle00205-08-04ma -itait 0102067oam 2200601 450 991071360710332120200715144013.0(CKB)5470000002503607(OCoLC)1030288077(OCoLC)971497457(OCoLC)1084460817(OCoLC)995470000002503607(EXLCZ)99547000000250360720180402d1990 ua 0engurbn||||||abpurbn||||||adatxtrdacontentcrdamediacrrdacarrierMap of mean annual runoff for the northeastern, southeastern, and mid-Atlantic United States, water years 1951-80 /by William R. Krug [and five others] ; prepared in cooperation with the U.S. Environmental Protection AgencyMadison, Wis. :U.S. Geological Survey,1990.Denver, Colo. :U.S. Geological Survey, Books and Open-File Reports Section.1 online resource (iv, 11 pages) mapsWater-resources investigations report ;88-4094Map on folded leaf in pocket.Includes bibliographical references (page 11).RunoffEast (U.S.)MapsRunoffEast (U.S.)StatisticsRunofffastEast United StatesfastMaps.fastStatistics.fastMaps.lcgftStatistics.lcgftRunoffRunoffRunoff.551.488Krug William R.1389465United States.Environmental Protection Agency.Geological Survey (U.S.),OCLCEOCLCEOCLCOCOPOCLCFOCLCQOCLOCLCQGPOBOOK9910713607103321Map of mean annual runoff for the northeastern, southeastern, and mid-Atlantic United States, water years 1951-803491430UNINA03053nam 22006255 450 991068647330332120251008133521.09783031107337303110733010.1007/978-3-031-10733-7(CKB)5840000000241928(DE-He213)978-3-031-10733-7(MiAaPQ)EBC7236692(Au-PeEL)EBL7236692(OCoLC)1385454689(MiAaPQ)EBC7235459(EXLCZ)99584000000024192820230408d2023 u| 0engurnn|008mamaatxtrdacontentcrdamediacrrdacarrierInterdisciplinary Value Theory /by Steffen Steinert1st ed. 2023.Cham :Springer International Publishing :Imprint: Palgrave Macmillan,2023.1 online resource (IX, 112 p.) 9783031107320 3031107322 1. Introduction – The many faces of value -- 2. Psychology and value -- 3. Sociology and value -- 4. Anthropology and value -- 5. Philosophy and value -- 6. A bridge between disciplines.This book offers an interdisciplinary introduction to value theory. It reviews how researchers in four academic disciplines – psychology, sociology, anthropology, and philosophy – understand value and value change. It offers an introduction for researchers in these disciplines about how other disciplines define, theorize, and investigate value(s) to foster interdisciplinary communication. The book identifies and summarizes similarities and differences of value theory between the academic disciplines and highlights promising areas where each discipline can learn from the others. Steffen Steinert is Assistant Professor in the Ethics and Philosophy section at Delft University of Technology. In his research, he focuses on fundamental theoretical issues of ethics and philosophy of technology - particularly the relation between values and technology, and the link between emotions and technology. Steffen’s work is published in top-tier peer-reviewed journals and he teaches philosophy and ethics to diverse audiences.Philosophy of mindEthicsNormativity (Ethics)Philosophy and social sciencesMoral PsychologyNormative EthicsPhilosophy of the Social SciencesPhilosophy of mind.Ethics.Normativity (Ethics)Philosophy and social sciences.Moral Psychology.Normative Ethics.Philosophy of the Social Sciences.155.825121.8Steinert Steffenauthttp://id.loc.gov/vocabulary/relators/aut1354741MiAaPQMiAaPQMiAaPQBOOK9910686473303321Interdisciplinary Value Theory3355639UNINA