01922nam 2200349 450 991068337670332120230921222848.03-0365-6919-7(CKB)5700000000354464(NjHacI)995700000000354464(EXLCZ)99570000000035446420230703d2023 uy 0engur|||||||||||txtrdacontentcrdamediacrrdacarrierCommemorative Issue in Honor of Centennial of the Discovery of Vitamin D-The Central Role of Vitamin D in Physiology /edited by Carsten CarlbergBasel :MDPI,2023.1 online resource (414 pages)3-0365-6918-9 This reprint is about vitamin D, a molecule that can be absorbed from certain foods, such as fatty fish, which can also be produced endogenously when we expose our skin to sufficient doses of ultraviolet B radiation. When vitamin D is metabolized into 1,25(OH)2D3 (also called calcitriol), it acts as a high-affinity ligand for the transcription factor VDR, i.e., it has direct effects on gene regulation. The key physiological functions of vitamin D are the regulation of calcium homeostasis, which is essential for bone mineralization, and the modulation of the immune system by stimulating innate immunity and preventing overreactions of adaptive immunity. This reprint presents recent developments and the latest research in the fascinating broad range of today's vitamin D biology, from evolution to systems biology.Vitamin DVitamin D.612.399Carlberg CarstenNjHacINjHaclBOOK9910683376703321Commemorative Issue in Honor of Centennial of the Discovery of Vitamin D-The Central Role of Vitamin D in Physiology3085530UNINA