02151nam 2200361 450 991068336600332120230703095537.03-0365-6897-2(CKB)5700000000354572(NjHacI)995700000000354572(EXLCZ)99570000000035457220230703d2023 uy 0engur|||||||||||txtrdacontentcrdamediacrrdacarrierModel-Informed Precision Dosing /edited by Jonás Samuel Pérez-Blanco, José Martínez LanaoBasel :MDPI - Multidisciplinary Digital Publishing Institute,2023.1 online resource (320 pages)3-0365-6896-4 Model-informed precision dosing (MIPD) is an advanced quantitative approach focusing on individualized treatment optimization. MIPD integrates mathematical models of drugs and diseases combined with individual patient characteristics (e.g., genotype, anthropometric factors, and organ function). MIPD has been highlighted as a useful tool for drug dosage selection in both the drug development process and clinical practice and it is a rapidly growing discipline that is supported by the main drug regulatory agencies. Despite the potential benefits of this methodology toward personalized medicine, its application is still limited. The Special Issue presented here includes several PKPD and PBPK models focused on improving the current state of art regarding the PK behaviour of different drugs with the aim of improving the efficacy/safety balance of these treatments and their clinical outcome; the Special Issue is intended to be of particular interest for clinical pharmacologists, pharmacometricians, and specific clinicians who routinely use the considered drugs.DrugsDosageDrugsDosage.615.14Pérez-Blanco Jonás SamuelLanao José MartínezNjHacINjHaclBOOK9910683366003321Model-Informed Precision Dosing3086503UNINA