02965nam 2200385 450 991067439860332120230625131909.0(CKB)5400000000046276(NjHacI)995400000000046276(EXLCZ)99540000000004627620230625d2022 uy 0engur|||||||||||txtrdacontentcrdamediacrrdacarrierNASH and Systemic Complications From Basic to Clinical Research /Ronit Shiri-Sverdlov and Sabine BaumgartnerBasel, Switzerland :MDPI - Multidisciplinary Digital Publishing Institute,2022.1 online resource (232 pages)3-0365-2978-0 Nonalcoholic fatty liver disease (NAFLD) is known as the hepatic manifestation of the metabolic syndrome, and while most patients develop simple steatosis, up to one-third can develop nonalcoholic steatohepatitis (NASH). NASH is a chronic inflammatory condition of the liver that can further progress to fibrosis and cirrhosis, which may eventually lead to liver failure and death. While we have increased our mechanistic knowledge regarding the pathogenesis of NASH within the last decade, treatment options are still limited and liver biopsies have remained the gold standard for diagnosis. To achieve major clinical breakthroughs for NASH patients, it is not sufficient to use a single animal model, since each model has specific limitations. Furthermore, we should rely more on alternative models such as organ-on-a-chip, which will enable us to explore unknown aspects of disease pathogenesis much faster and serve as clinically relevant surrogates for murine models. Another important direction for the improvement of patient health is to pay more attention to extrahepatic, organ-specific and systemic effects, which are associated with NASH. The articles in this Special Issue include an up-to-date overview of the rapidly developing technologies, novel targets for intervention and insights in the field in NASH. Additionally, these articles describe the major challenges in the field, strategies to overcome them and suggestions for future directions. To improve patient's outcome, clinicians, as well as scientists with biomedical, nutrition, physics and mathematics backgrounds, should join forces. Although challenges remain, the future of the field seems promising as these novel technologies and developments are expected to lead to progress in NASH.NASH and Systemic Complications Clinical trialsBiomedical materialsClinical trials.Biomedical materials.610.724Shiri-Sverdlov Ronit1367755Baumgartner SabineNjHacINjHaclBOOK9910674398603321NASH and Systemic Complications3391558UNINA